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| 1 | Review of the treatment of liver hydatid cysts显示文摘A review was carried out in Medline,LILACS and the Cochrane Library.Our database search strategy included the following terms: 'hydatid cyst','liver','management','meta-analysis' and 'randomized controlled trial'.No language limits were used in the literature search.The latest electronic search date was the 7th of January 2014.Inclusion and exclusion criteria: all relevant studies on the assessment of therapeutic methods for hydatid cysts of the liver were considered for analysis.Information from editorials,letters to publishers,low quality review articles and studies done on animals were excluded from analysis.Additionally,well-structured abstracts from relevant articles were selected and accepted for analysis.Standardized forms were designed for data extraction; two investigators entered the data on patient demographics,methodology,recurrence of HC,mean cyst size and number of cysts per group.Four hundred and fourteen articles were identified using the previously described search strategy.After applying the inclusion and exclusion criteria detailed above,57 articles were selected for final analysis: one meta-analysis,9 randomized clinical trials,5 non-randomized comparative prospective studies,7 non-comparative prospective studies,and 34 retrospective studies(12 comparative and 22 noncomparative).Our results indicate that antihelminthic treatment alone is not the ideal treatment for liver hydatid cysts.More studies in the literature support the effectiveness of radical treatment compared with conservative treatment.Conservative surgery with omentoplasty is effective in preventing postoperative complications.A laparoscopic approach is safe in some situations.Percutaneous drainage with albendazole therapy is a safe and effective alternative treatment for hydatid cysts of the liver.Radical surgery with preand post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates. | Concepción Gomez i Gavara Rafael López-Andújar Tatiana Belda Ibáez José M Ramia ngel ngel Moya Herraiz Francisco Orbis Castellanos Eugenia Pareja Ibars Fernando San Juan Rodríguez | 2015 | World Journal of Gastroenterology2015，21，1： | 8 |
| 2 | Apolipoprotein E in Alzheimer’s disease and other neurological disorders显示文摘 | Philip B Verghese Joseph M Castellano David M Holtzman | 2011 | Lancet Neurology2011，，3： | 2 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 5 | Synthetic cannabinoids 2015: An update for pediatricians in clinical practice显示文摘Synthetic cannabinoids are a group of substances in the world of designer drugs that have become increasingly popular over the past few years. Synthetic cannabinoids are a chemically diverse group of compounds functionally similar to THC. Since first appearing on the world market a few years ago these compounds have evolved rapidly. Newer more potent analogues have been developed. Identifying youth who abuse these substances can be difficult. Newer forms of consumption have also evolved. These products are now manufactured in products that look like natural cannabis resin and in liquid cartridges used in electronic cigarettes. Synthetic cannabinoids appear to be associated with potentially dangerous health effects that are more severe than that of marijuana. Some synthetic cannabinoid compounds have been associated with serious physical consequences, such as, seizures, myocardial infarction and renal damage. In addition, psychoactive effects, such as aggression, confusion, anxiety and psychosis have also been reported. The diagnosis remains primarily clinical with toxicological confirmation difficult due to manufacturers constantly developing new analogues to avoid detection. Pediatricians are urged to familiarize themselves with these drugs and the typical presentations of patients who use them. | Daniel Castellanos Leonard M Gralnik | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 6 | Microembolic signal monitoring in hemispheric acute ischaemic stroke:A prospective study显示文摘 | Serena J Segura T Castellanos M | 2000 | Cerebrovasc Dis2000，10，4： | 1 |
| 7 | Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure显示文摘 | Rizzoni D Porteri E Castellano M | 1998 | Hypertension1998，31，： | 1 |
| 8 | Vertebral artery embolism after acute cervical spine trauma显示文摘 | VERAS L M PEDRAZA GUTIERREZ S CASTELLANOS J el al | 2000 | Spine2000，25，9： | 1 |
| 9 | Cerebral hemodynamic reserve and early neurologic deterioration in acute ischemic stroke显示文摘 | Alvarez FJ Segura T Castellanos M | 2004 | J Cereb Blood Flow Metab2004，24，： | 1 |
| 10 | Fine needle cytology of complex thyroid nodules显示文摘 | Cappelli C Pirola 1 Castellano M | | 0，，4： | 1 |
| 11 | Role of nitric oxide under saline stress : Implications on pro-line metabolism显示文摘 | L6PEZ-CARR6IN A I CASTELLANO R ROSALES M A | 2008 | Biology Planarum2008，52，3： | 1 |
| 12 | Study of interferon-13 antiviral activity against Herpes simplex virus type 1 in neuron-enriched trigeminal ganglia cultures 显示文摘 | Low-Calle A M Prada-Arismendy J Castellanos J E | 2014 | Virus Res2014，180，： | 1 |
| 13 | Phase Ⅱ trial of cisplatin and gemcitabine in advanced squamous-cell carcinoma of the head and neck显示文摘 | Hitt R Castellano D Hidalgo M | 1998 | Amm 0ncol1998，9，12： | 1 |
| 14 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 15 | Microembolic signal monitoring in hemispheric acute ischaemic stroke:a prospective study显示文摘 | Segura T Castellanos M | 2000 | Cerebrovasc Dis2000，10，4： | 1 |
| 16 | Direct cell-ceU contact required for neurotrophic effect of chrtanaffin cells on neural progenitor cells显示文摘 | SCHUlVlM M A CASTELLANOS D A FRYDEL B R | 2003 | Brain Res Dev Brain Res2003，146，12： | 1 |
| 17 | Identification and quantitation of allelochemicals from the Lichen lethariella canariensis: phytotoxicity and antioxidative activity显示文摘 | TOLEDO M F J CASTELLANO A G ROSAS F E | 2003 | J Chem Ecol2003，29，9： | 1 |
| 18 | The role of macrophages and mast cells in lymphangiogenesis and angiogen- esis in cervical carcinogenesis 显示文摘 | Utrera - Barillas D Castro - ManxTeza M Castellanos E | 2010 | Exp Mol PathoI2010，89，2： | 1 |
| 19 | Multiple origins of sequestrate thngi related to Cortiruzrius (Cortinariaceae) 显示文摘 | Peintner U Bougher N L Castellano M A | 2001 | American Journal of Botany2001，88，： | 1 |
| 20 | Kisspeptins and the control of gonadotropin secretion in male and female ro-dents 显示文摘 | RAO J CASTELLANO J M NAVARRO V M | 2009 | Peptides2009，30，1： | 1 |
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