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| 1 | Histone modifications:Targeting head and neck cancer stem cells显示文摘Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer worldwide, and is responsible for a quarter of a million deaths annually. The survival rate for HNSCC patients is poor, showing only minor improvement in the last three decades. Despite new surgical techniques and chemotherapy protocols, tumor resistance to chemotherapy remains a significant challenge for HNSCC patients. Numerous mechanisms underlie chemoresistance, including genetic and epigenetic alterations in cancer cells that may be acquired during treatment and activation of mitogenic signaling pathways, such as nuclear factor kappa-light-chain-enhancer-of activated B cell, that cause reduced apoptosis. In addition to dysfunctional molecular signaling, emerging evidence reveals involvement of cancer stem cells(CSCs) in tumor development and in tumor resistance to chemotherapy and radiotherapy. These observations have sparked interest in understanding the mechanisms involved in the control of CSC function and fate. Post-translational modifications of histones dynamically influence gene expression independent of alterations to the DNA sequence. Recent findings from our group have shown that pharmacological induction of posttranslational modifications of tumor histones dynamically modulates CSC plasticity. These findings suggest that a better understanding of the biology of CSCs in response to epigenetic switches and pharmacological inhibitors of histone function may directly translate to the development of a mechanism-based strategy to disrupt CSCs. In this review, we present and discuss current knowledge on epigenetic modifications of HNSCC and CSC response to DNA methylation and histone modifications. In addition, we discuss chromatin modifications and their role in tumor resistance to therapy. | John M Le Cristiane H Squarize Rogerio M Castilho | 2014 | World Journal of Stem Cells2014，6，5： | 6 |
| 2 | Semaphorin 4D provides a link between axon guidance processes and tumorinduced angiogenesis显示文摘 | Basile J R Castilho R M Williams V P | 2006 | Proc Natl Acad Sci USA2006，103，24： | 1 |
| 3 | Trends in the analytical methods for the determinationof trans fatty acids content in foods显示文摘 | ALBUQUERQUE T G COSTA H S CASTILHO M C | 2011 | Trends in Food Scienceand Technology2011，22，11： | 1 |
| 4 | Long-term exposure to high glucose increases the content of several exocy- totic proteins and of vesicular GABA transporter in cultured retinal neural cells显示文摘 | BAPTISTA F I CASTILHO A F GASPAR J M | 2015 | Nenrosci Lett2015，602，： | 1 |
| 5 | Immunohisto-chemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system显示文摘 | Squarize C H Castilho R M Santos P D Jr | 2002 | J Oral Pathol Med2002，31，： | 1 |
| 6 | Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxiccity on multidrug resistant and sensitive leukemia cell lines显示文摘 | Fernandes J Castilho R O da Costa M R | 2003 | Cancer Lett2003，190，2： | 1 |
| 7 | Semaphorin 4D provides a link between axon guidance processes and tumor- induced angiogenesis显示文摘 | Basile J R Castilho R M Williams V P | 2006 | Proc Natl Acad Sci U S A2006，103，24： | 1 |
| 8 | Effect of superstimulatory treatments on the expression of genes related to ovulatory capacity, oocyte competence and embryo development in cattle 显示文摘 | BARROS C M SATRAPA R A CASTILHO A C | 2012 | Reprod Fertil Dev2012，25，1： | 1 |
| 9 | Determination of chloramphenicol residues in rainbow trouts by gas chromatography-tandem mass spectrometry 显示文摘 | SANTOS L BARBOSA J CASTILHO M | 2005 | Anal Chim Acta2005，529，12： | 1 |
| 10 | Develo- pment and evaluation of a nanoporous iron (hydr) oxide electrode for phosphate sensing显示文摘 | Moss R E Jackowski J J Castilho M D | 2011 | Electroanalysis2011，23，7： | 1 |
| 11 | Virus-like particles in vaccine development显示文摘 | ROLDAO A MELLADO M C CASTILHO L R | 2010 | Expert Review of Vaccines2010，9，10： | 1 |
| 12 | Non - Invasive Assess- ment of Fibrosis Using Color Doppler Ultrasound in Patients with Hepatitis C Virus in the Amazon Rainforest, Brazil显示文摘 | Leo J Brock M Castilho M | 2012 | The American journal of tropical medicine and hygiene2012，86，2： | 1 |
| 13 | Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca^2 + ions : A proposed model for phosphate-stimulated lipid peroxidation 显示文摘 | KOWALTOWSKI A J CASTILHO R F GRIJALBA M T | 1996 | The Journal of Biological Chemistry1996，271，6： | 1 |
| 14 | Augmented Writ sig- naling in a mammalian model of accelerated aging显示文摘 | Liu H Fergusson M M Castilho R M | 2007 | Science2007，317，5839： | 1 |
| 15 | Storage space vs handling work in container terminals显示文摘 | Taleb I M Castilho B D Daganzo C F | 1993 | Transportation Research1993，27，1： | 1 |
| 16 | Production of poly (3-hydroxybutyrate) by solid-state fermentation with Ralstonia eutropha 显示文摘 | Oliveira F C Freire D M G Castilho L R | 2004 | Biotechnology Letters2004，26，： | 1 |
| 17 | Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma 显示文摘 | SQUARIZE C H CASTILHO R M SRIURANPONG V | 2006 | Neoplasia2006，8，9： | 1 |
| 18 | Regional wind fields and dunefield migration, southern Brazil显示文摘 | Hesp P de Castilhos J A da Silva G M | 2007 | Earth Surface Processes and Landforms2007，32，4： | 1 |
| 19 | 2D QSAR studies on thyroid hormone receptor ligands显示文摘 | VALADARES N F CASTILHO M S POLIKARPOVA I | 2007 | Bioorganic & Medicinal Chemistry2007，15，： | 1 |
| 20 | Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis显示文摘 | John R Basile Rogerio M Castilho | 2006 | Proc Natl Acad Sci U S A2006，103，24： | 1 |
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