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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Ionic Transport and Electronic Structure in Poly (3,4-ethylenedioxythiophene)显示文摘 | Carlberg Catarina Chen Xiwen Ingan(a)s Olle | | 0，，1： | 1 |
| 4 | Induction of cytochrome c-mediated apoptosis by amyloid β 25- 35 requires functional mitochondria 显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 5 | Induction of cytochrome e-mediated apoptosis by amyloid β 25-35 requires functional mitochondria显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 6 | Neurocutaneous island flaps in upper 1imb coverage:experience with 44 clinical cases显示文摘 | Bertelli JA Catarina S | 1997 | J Hand Surg1997，22，3： | 1 |
| 7 | Free amino acid composition of Annona(Annonaceae)fruit species of economic interest显示文摘 | Egydio P M Catarina C S Floha E S | 2013 | Industrial Crops and Products2013，45，： | 1 |
| 8 | Low-grade mucinous appendiceal neoplasm mimicking an ovarian lesion: A case report and review of literature显示文摘BACKGROUND Appendiceal tumors are rare lesions that may not be easily differentiated from primary ovarian lesions preoperatively,despite the use of advanced diagnostic methods by experienced clinicians.CASE SUMMARY A 59-year-old G2P2 woman,with chronic pelvic pain,underwent a pelvic ultrasound that revealed an adnexal mass measuring 58 mm×34 mm×36 mm,with irregular borders,heterogeneous echogenicity,no color Doppler vascularization and without acoustic shadowing.Normal ovarian tissue was visualized in contact with the lesion,and it was impossible to separate the lesion from the ovary by applying pressure with the ultrasound probe.Ascites,peritoneal metastases or other alterations were not observed.With the international ovarian tumor analysis ADNEX model,the lesion was classified as a malignant tumor(the risk of malignancy was 27.1%,corresponding to Ovarian-Adnexal Reporting Data System category 4).Magnetic resonance imaging confirmed the presence of a right adnexal mass,apparently an ovarian tumor measuring 65 mm×35 mm,without signs of invasive or metastatic disease.During explorative laparotomy,normal morphology of the internal reproductive organs was noted.A solid mobile lesion involved the entire appendix.Appendectomy was performed.Inspection of the abdominal cavity revealed no signs of malignant dissemination.Histopathologically,the appendiceal lesion corresponded to a completely resected low-grade mucinous appendiceal neoplasm(LAMN).CONCLUSION The appropriate treatment and team of specialists who should provide health care to patients with seemingly adnexal lesions depend on the nature(benign vs malignant)and origin(gynecological vs nongynecological)of the lesion.Radiologists,gynecologists and other pelvic surgeons should be familiar with the imaging signs of LAMN whose clinical presentation is silent or nonspecific.The assistance of a consultant specializing in intestinal tumors is important support that gynecological surgeons can receive during the operation to offer the patient with intestinal pathology an optimal intervention. | André Luís Borges Catarina Reis-de-Carvalho Martinha Chorão Helena Pereira Dusan Djokovic | 2021 | World Journal of Clinical Cases2021，9，10： | 1 |
| 9 | Absence of folliclestimulating hormone receptor activating mutations in women with iatrogenic ovarian hyperstimulation syndrome显示文摘 | Catarina B D Paulo S Eduardo M | 2005 | Fertil Steril2005，83，6： | 1 |
| 10 | Application of PCR ribotyping and tDNA-PCR for Klebsiella pneumoniae identification显示文摘 | Ana Catarina S L Juliana F R Maysa B M C | 2007 | Mere Inst Oswaldo Cruz Rio de Janeiro2007，102，7： | 1 |
| 11 | Neurocutaneous island flaps inupper limb coverage Experience with 44 clinical casses 显示文摘 | Bertelli JA Catarina S | 1997 | Hand Surg Am1997，22，3： | 1 |
| 12 | Chitosan- reinforced alginate microspheres obtained through the emulsification/ internal gelation technique 显示文摘 | AntJonio J R Catarina S Domingos F | 2005 | European Journal of Pharmaceutical Sciences2005，25，： | 1 |
| 13 | Temperature and feed strategy effects on sulfate and organic matter removal in an AriSBB 显示文摘 | Augusto L O C Catarina S A C Suzana M R | 2011 | Joumal of Environmental Management2011，92，： | 1 |
| 14 | Extending modules with injective or semisimple summands 显示文摘 | Catarina S C | 1998 | J Pure Applied Alg1998，127，2： | 1 |
| 15 | A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma显示文摘 | José Carlos Machado Céu Figueiredo Paulo Canedo Paul Pharoah Ralph Carvalho Sérgio Nabais Catarina Castro Alves Maria Luisa Campos Leen-jan Van Doorn Carlos Caldas Raquel Seruca Fátima Carneiro Manuel Sobrinho-Sim?es | 2003 | Gastroenterology2003，，2： | 1 |
| 16 | Predicting pork quality using Vis/NIR spectroscopy显示文摘 | Juliana M B Saulo da L S Catarina A G | 2015 | Meat Science2015，108，： | 1 |
| 17 | Hydroxyapatite micro-and nanoparticles:Nucle- ation and growth mechanisms in the presence of citrate species 显示文摘 | MANUEL A M CATARINA S MARIA M A MARIA E V C | 2008 | Journal of Colloid and Interface Science2008，318，： | 1 |
| 18 | A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma显示文摘 | José Carlos Machado Céu Figueiredo Paulo Canedo Paul Pharoah Ralph Carvalho Sérgio Nabais Catarina Castro Alves Maria Luisa Campos Leen-jan Van Doorn Carlos Caldas Raquel Seruca Fátima Carneiro Manuel Sobrinho-Sim?es | 2003 | Gastroenterology2003，，2： | 1 |
| 19 | Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α显示文摘 | Sónia C. Correia Renato X. Santos Sandra M. Cardoso Maria S. Santos Catarina R. Oliveira Paula I. Moreira | 2011 | Neurobiology of Disease2011，，1： | 1 |
| 20 | A bsence of follicle- stimulating hormone recep tor activating mutations in w omen with iatrogenic ovarian hyperstimulation syndrome显示文摘 | Catarina BD Paulo S Eduardo M | 2005 | Fertil Stedl2005，83，6： | 1 |
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