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| 1 | Current update on molecular cytogenetics, diagnosis and management of gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract and are thought to arise from precursors of the interstitial cells of Cajal.GISTs can arise anywhere in the GI tract,but most commonly originate from the stomach and small intestine.The majority of GISTs occur as a result of activating mutations in two receptor protein tyrosine kinases:KIT and/or platelet-derived growth factor receptor-α.Mutational analyses allow for predicting patient prognosis and treatment response.Clinical presentations can vary from no symptoms,typical in the case of small incidentally found tumors,to GI bleeding,abdominal discomfort,and ulcer-related symptoms when the tumor is enlarged.Imaging plays a critical role in the diagnosis and management of these tumors with multiphasic computed tomography serving as the imaging modality of choice.Magnetic resonance imaging and positron emission tomography-computed tomography can serve as imaging adjuncts in lesion characterization,especially with liver metastases,and subsequent staging and assessment for treatment response or recurrence.Surgical resection is the preferred management for small GISTs,while tyrosine kinase inhibitors−imatinib mesylate and sunitinib malate−serve as crucial molecular-targeted therapies for locally advanced and metastatic GISTs.This review article highlights the clinical presentation,pathology and molecular cytogenetics,imaging features,and current management of GISTs. | Mindy X Wang Catherine Devine Nicole Segaran Dhakshinamoorthy Ganeshan | 2021 | World Journal of Gastroenterology2021，27，41： | 5 |
| 2 | Features of primary pancreatic lymphoma:A bi-institutional review with an emphasis on typical and atypical imaging features显示文摘BACKGROUND Primary pancreatic lymphoma(PPL)is a rare neoplasm.Being able to distinguish it from other pancreatic malignancies such as pancreatic ductal adenocarcinoma(PDAC)is important for appropriate management.Unlike PDAC,PPL is highly sensitive to chemotherapy and usually does not require surgery.Therefore,being able to identify PPL preoperatively will not only direct physicians towards the correct avenue of treatment,it will also avoid unnecessary surgical intervention.AIM To evaluate the typical and atypical multi-phasic computed tomography(CT)imaging features of PPL.METHODS A retrospective review was conducted of the clinical,radiological,and pathological records of all subjects with pathologically proven PPL who presented to our institutions between January 2000 and December 2020.Institutional review board approval was obtained for this investigation.The collected data were analyzed for subject demographics,clinical presentation,laboratory values,CT imaging features,and the treatment received.Presence of all CT imaging findings including size,site,morphology and imaging characteristics of PPL such as the presence or absence of nodal,vascular and ductal involvement in these subjects were recorded.Only those subjects who had a pre-treatment multiphasic CT of the abdomen were included in the study.RESULTS Twenty-nine cases of PPL were diagnosed between January 2000 and December 2020(mean age 66 years;13 males/16 females).All twenty-nine subjects were symptomatic but only 4 of the 29 subjects(14%)had B symptoms.Obstructive jaundice occurred in 24%of subjects.Elevated lactate dehydrogenase was seen in 81%of cases,whereas elevated cancer antigen 19-9 levels were present in only 10%of cases for which levels were recorded.The vast majority(90%)of tumors involved the pancreatic head and uncinate process.Mean tumor size was 7.8 cm(range,4.0-13.8 cm).PPL presented homogenous hypoenhancement on CT in 72%of cases.Small volume peripancreatic lymphadenopathy was seen in 28%of subjects.Tumors demonstrated encasement of superior mesenteric vessels in 69%of cases but vascular stenosis or occlusion only manifested in 5 out of the twentynine individuals(17%).Mild pancreatic duct dilatation was also infrequent and seen in only 17%of cases,whereas common bile duct(CBD)dilation was seen in 41%of subjects.Necrosis occurred in 10%of cases.Size did not impact the prevalence of pancreatic and CBD dilation,necrosis,or mesenteric root infiltration(P=0.525,P=0.294,P=0.543,and P=0.097,respectively).Pancreatic atrophy was not present in any of the subjects.CONCLUSION PPL is an uncommon diagnosis best made preoperatively to avoid unnecessary surgery and ensure adequate treatment.In addition to the typical CT findings of PPL,such as homogeneous hypoenhancement,absence of vascular stenosis and occlusion despite encasement,and peripancreatic lymphadenopathy,this study highlighted many less typical findings,including small volume necrosis and pancreatic and bile duct dilation. | Nicole Segaran Kumaresan Sandrasegaran Catherine Devine Mindy X Wang Chintan Shah Dhakshinamoorthy Ganeshan | 2021 | World Journal of Clinical Oncology2021，12，9： | 2 |
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| 4 | Inhibition of iNOS augments cardiovascular action of noradrenaline in streptozotocin-induced diabetes显示文摘 | CHENG X CATHERINE C PANG Y | 2004 | Cardiovasc Res2004，，64： | 1 |
| 5 | Polyomavirus in renal transplantation: A hot problem 显示文摘 | Catherine B Laurent W Patricia X | 2008 | Transplantation2008，85，： | 1 |
| 6 | Corrosion effects between molten salts and thermal storage material for concentrated solar power plants显示文摘 | Stéphanie Guillot Abdessamad Faik Aydar Rakhmatullin Julien Lambert Emmanuel Veron Patrick Echegut Catherine Bessada Nicolas Calvet Py X | 2012 | Applied Energy2012，94，6： | 1 |
| 7 | One-year incidence of suicide attempts and associated risk and protective factors among adolescents显示文摘 | Robert ER Catherine RR Yun X | 2010 | Archives of Suicide Research2010，14，1： | 1 |
| 8 | The effect of alumina on the electrical conductivity of silicate perovsikite 显示文摘 | X u Yousheng Catherine McCammon Poe B T | 1998 | Science1998，282，5390： | 1 |
| 9 | CFD analysis of industrial multi-staged stirred vessels显示文摘 | Marion A G Rodolphe S Catherine X | 2006 | Chemical Engineering Process2006，45，1： | 1 |
| 10 | Investigation of confluent boundary layers in high-lift flows显示文摘 | Susan X Ying Frank W Spaid Catherine B McGinley | 1999 | Journal of Aircraft1999，36，3： | 1 |
| 11 | Effect of gas liquid separator and liquid height on the global hydrodynamic parameters of an external loop airlift contactor 显示文摘 | CHAFAA B CATHERINE X JEAN P R | 1997 | Chemical Engineering Journal1997，66，2： | 1 |
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