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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | Image assessment for a destination with limited comparativeadvantages显示文摘 | Cathy H C Hsua Kara Wolfeb Soo K Kang | 2004 | Tourism Management2004，25，： | 1 |
| 3 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | Margie C Cathy L | 2007 | International Anesthesia Research Society2007，105，： | 1 |
| 4 | Technology to cool down global warming显示文摘 | CATHY C CHARLENE C | 1999 | Chem Eng1999，106，： | 1 |
| 5 | Effects of Travel MotivationPast Expe- rience, Perceived Constraint, and Attitude on Revisit Inten- tion显示文摘 | Songs H Cathy H C H | 2009 | Journal of Travel Research2009，48，1： | 1 |
| 6 | Evidence-based systematic review:Effects of oral motor interventions on feeding and swallowing in preterm infants显示文摘 | Joan A Healther C Cathy L | 2010 | American Journal of Speech-Language Pathology2010，19，： | 1 |
| 7 | A model of senior tourism motivations-Anecdotes from Beijing and Shanghai显示文摘 | Cathy H Liping C Kevin W | 2007 | Tourism Management2007，，28： | 1 |
| 8 | Nanocompatible chemistry toward fabrication of arget- specific gold nanopartieles 显示文摘 | Raghuraman K Valeric R Cathy C | 2006 | J Am Chemsoc2006，128，11： | 1 |
| 9 | Tourism and China's Development:Policies,Regional Economic Growth and Ecotourism显示文摘 | | 2003 | Tourism Management2003，24，3： | 1 |
| 10 | The effetcs of oral-motor exercises on swallowing in children: an evidence-based systematic re- view显示文摘 | Joan A Heather C Cathy L | 2010 | Developmental Medicine & Child Neurology2010，52，： | 1 |
| 11 | Prognostic significance of lymph node metastasis found during pulmonary metastasectomy for extrapulmonary carcinoma显示文摘 | Sina Ercan Francis C Nichols Victor F Trastek Claude Deschamps Mark S Allen Daniel L Miller Cathy D Schleck Peter C Pairolero | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 12 | Surface Characterizations of Carbon Multiwall Nanotubes: Comparison Between Surface Active Sites and Raman Spectroscopy显示文摘 | Cathie V G Michel C Joseph | 2004 | Journal of Physical of Chemistry B2004，，19： | 1 |
| 13 | Transitional care in skilled nursing facilities:a muhiple case study显示文摘 | MARK T CATHI EEN C E MARRY D N | 2016 | BMC HealthServRes2016，，： | 1 |
| 14 | Tourist behaviour: theme and conceptual schemes显示文摘 | Hsu Cathy H C | 2006 | Annals of Tourism Research2006，33，3： | 1 |
| 15 | MYB transcription factors in Arabidopsis显示文摘 | Christian Dubos Ralf Stracke Erich Grotewold Bernd Weisshaar Cathie Martin Lo?c Lepiniec | 2010 | Trends in Plant Science2010，，10： | 1 |
| 16 | A chaotic heat - exchanger for PEMFC cooling applications 显示文摘 | YAHIA L BRUNO A CATHY C | 2005 | Journal of Power Sources2005，，156： | 1 |
| 17 | Serum YKL-40 is associated with osteoarthritis and atherosclerosis in nonhuman primates显示文摘 | Thomas C Register Cathy S | 2001 | Clinical Chemistry2001，47，： | 1 |
| 18 | Nano compatible chemistry toword fabrication of arget-specific gold nanoparticles显示文摘 | RAGHURAMAN K VALERIE R CATHY C | 2006 | J Am Chem Soc2006，128，11： | 1 |
| 19 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 20 | Microsatellite markers in Canada geese (Branta canadensis)显示文摘 | Cathy J C | 2004 | Brief Communication2004，，： | 1 |
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