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| 1 | 接受替诺福韦与恩替卡韦治疗的慢性乙型肝炎患者中肝细胞癌发病率的比较:一项系统评价和荟萃分析显示文摘【据Lancet Gastroenterol Hepatol 2020年12月报道】题:接受替诺福韦与恩替卡韦治疗的慢性乙型肝炎患者中肝细胞癌发病率的比较:一项系统评价和荟萃分析(作者Tseng CH等)。目前尚不清楚富马酸替诺福韦二吡呋酯和恩替卡韦与慢性乙型肝炎患者发生肝细胞癌风险的关系是否不同,既往开展的荟萃分析得出了与实质性的异质性相互矛盾的结论. | TSENG CH HSU YC CHEN TH 李腊梅(报道) 牛俊奇(报道) | 2020 | 临床肝胆病杂志2020，36，12： | 10 |
| 2 | TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis显示文摘AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June 1992.Allpatients had a follow-up every other week for atleast 6 months after transfusion.Eightyrecipients received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened blood.Recipients with alanine aminotransferase level>2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and cytomegalovirus.TTV infection was defined by the positivity forserum TTV DNA using the polymerase chainreaction method.RESULTS Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels>90 IU/L.Five patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV DNA,and four of them hadsero-conversion of TTV DNA.CONCLUSION TTV can be transmitted viablood transfusion.Two recipients infected byTTV alone may be associated with the hepatitis.However,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis. | Yang SS Wu CH Chen TH Huang YY Huang CS | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 3 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 4 | Factors influencing teamwork and collaboration within a tertiary medical center显示文摘AIM: To understand how work climate and related factors influence teamwork and collaboration in a large medical center. METHODS: A survey of 3462 employees was conducted to generate responses to Sexton's Safety Attitudes Questionnaire(SAQ) to assess perceptions of work environment via a series of five-point, Likert-scaled questions. Path analysis was performed, using teamwork(TW) and collaboration(CO) as endogenous variables. The exogenous variables are effective communication(EC), safety culture(SC), job satisfaction(JS), work pressure(PR), and work climate(WC). The measure-ment instruments for the variables or summated subscales are presented. Reliability of each sub-scale are calculated. Alpha Cronbach coefficients are relatively strong: TW(0.81), CO(0.76), EC(0.70), SC(0.83), JS(0.91), WP(0.85), and WC(0.78). Confirmatory factor analysis was performed for each of these constructs. RESULTS: Path analysis enables to identify statistically significant predictors of two endogenous variables, teamwork and intra-organizational collaboration. Significant amounts of variance in perceived teamwork(R2 = 0.59) and in collaboration(R2 = 0.75) are accounted for by the predictor variables. In the initial model, safety culture is the most important predictor of perceived teamwork, with a β weight of 0.51, and work climate is the most significant predictor of collaboration, with a β weight of 0.84. After eliminating statistically insignificant causal paths and allowing correlated predictors1, the revised model shows that work climate is the only predictor positively influencing both teamwork(β = 0.26) and collaboration(β = 0.88). A relatively weak positive(β = 0.14) but statistically significant relationship exists between teamwork and collaboration when the effects of other predictors are simultaneously controlled.CONCLUSION: Hospital executives who are interested in improving collaboration should assess the work climate to ensure that employees are operating in a setting conducive to intra-organizational collaboration. | Shu Feng Chien Thomas TH Wan Yu-Chih Chen | 2012 | World Journal of Methodology2012，2，2： | 4 |
| 5 | SOURCE RADIATION AND RESPONSES OF WAVE PROPAGATION显示文摘Recordings of seismic waves propagating from earthquake source to a station at the earth’s surface are a system response function. The convolution operator in time domain can be simplified as a multiplication operator in frequency domain. We discuss in frequency domain the separation of source, path and site effects for global scaling of earthquake source radiation. Also discussed are source scaling model, faulting mechanism, and the H/V inversion problems with crustal and near surface structures. Gross features of apparent source spectra appear to be not much region dependent although there may be difference between tectonic styles within a region of tectonic mixture for which we need further study as data accumulate. Vertical spectra may be a better approach to approximate source radiation, as it has less crustal amplification effects than horizontal spectra. The H/V ratio is evidently a comprehensive indicator of amplification effects from near surface to deep structure. This gives it potential as an inversion tool to deduce site crustal structure. | CHEN Sheng zao 1 and Gail M Atkinson 2 (1. Geomatrix Consultants, Inc., 2101 Webster St., 12 th Floor, Oakland, CA 94612, USA, formerly at Dept. Earth Sciences & Ottawa Carleton Geoscience Center, Carleton University, Ottawa, Canada 2. Dept. Ea | 2001 | Geotectonica et Metallogenia2001，25，1： | 2 |
| 6 | Relationship Between Soil Properties and Different Fractions of Soil Hg显示文摘Correlation and path analysis methods were used to study the relationship between soil properties and the distribution of different soil Hg fractions with nine representative soils from Chongqing, China. Results showed that clay (< 2 m) could increase water-soluble Hg (r = 0.700*). Soil organic matter (OM) could enhance the increase of elemental Hg (r = 0.674*). The higher the base saturation percentage (BSP), the more the residual Hg (T = 0.684*). Organic Hg, the sum of acid-soluble organic Hg and alkali-soluble Hg, was positively affected by silt (2-20 μm) but negatively affected by pH, with the direct path coefficients amounting to 1.0487 and 0.5121, respectively. The positive effect of OM and negative effect of BSP on organic Hg were the most significant, with the direct path coefficients being 0.7614 and -0.8527, respectively. The indirect effect of clay (< 2 μm) via BSP (path coefficient = 0.4186) was the highest, showing that the real influencing factor in the effect of clay (< 2 μm) on acid-soluble organic Hg was BSP. Since the available Hg fraction, water-soluble Hg, was positively affected by soil clay content, and the quite immobile and not bioavailable residual Hg by soil BSP, suitable reduction of clay content and increase of BSP would be of much help to reduce the Hg availability and Hg activity in Hg-contaminated soils. | WU HONGTAO YU GUIFEN QING CHANGLE and CHEN TONGBIN Southwest Agricultural University, Chongqing 400716 (China) Institute of Geographic Sciences and Natural Resources, the Chinese Academy of Sciences, Beijing 100101 (China) Institute of Soil Science, th | 2001 | Pedosphere2001，11，3： | 2 |
| 7 | Advanced glycosylation end products induce inducible nitric oxide synthase (iNOS) expression via a p38 MAPK - dependent pathway 显示文摘 | Chang PC Chen TH Chang C J | 2004 | Kidney Int2004，65，5： | 1 |
| 8 | Multi-Slice CT angiography in diagnosing total versus near occlusions of the internal carotid artery :comparison with catheter angiography 显示文摘 | Chen CJ Lee TH Hsu HL | 2004 | Stroke2004，35，1： | 1 |
| 9 | Effect of preoperative bil- iary drainage on surgical outcome after pancreaticoduodenecto- my显示文摘 | Tsai YF Shyu JF Chen TH | 2006 | Hepatogastroenterology2006，53，： | 1 |
| 10 | High-Dose Misoprostol as an Alternative Therapy after Failed Medical Abortion显示文摘 | Li YT GQ Hou TH Chen | 2008 | Taiwan J Obstet Gynecol2008，47，4： | 1 |
| 11 | Angiotensin II stimulates hypoxia -inducible factor let accumulation in glomerular mesangial cells 显示文摘 | Chen TH Wang JF Chan P | 2005 | Ann N Y Acad Sci2005，1042，1： | 1 |
| 12 | Comparison Between F-18-FDG Positron Emission Tomography and Histology for the Assessment of Tumor Necrosis Rates in Primary Osteosareoma 显示文摘 | HUANG TL LIU R S CHEN TH | 2006 | J Chin Med Assoc2006，69，8： | 1 |
| 13 | Novel fuzzy feedback linearization strategy for control via differential geometry approach 显示文摘 | Li TH Huang C J Chen CC | 2010 | ISA Transactions2010，3，49： | 1 |
| 14 | Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus显示文摘 | Chen JP Cheng TH | | 0，，313： | 1 |
| 15 | Reprint of'Evaluating organophosphate poisoning in human serum with paper'显示文摘 | Yen TH Chen KH Hsu MY | 2015 | Talanta2015，1，145： | 1 |
| 16 | Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatle brain injury显示文摘 | Chen SF Hung TH Chen CC | 2007 | Life Se12007，81，4： | 1 |
| 17 | Pharmacokinetics of osthole in rat plasma using high-performance liquid chromatography显示文摘 | Tsai TH Tsai TR Chen CC | 1996 | J Pharmaceutical and Biomedical analysis1996，14，6： | 1 |
| 18 | Serum hepatitis B surfaee anti-gen concentration correlates with HBV DNA level in patients withchronic hepatitis B显示文摘 | Su TH Hsu CS Chen CL | 2010 | Antivir Ther2010，15，8： | 1 |
| 19 | Long- term results of scaphoid nonun- ion treated by intercalated bone grafting and Herbert' s screw fixa- tion: a study of 49 patients for at least five years 显示文摘 | Huang YC Liu Y Chen TH | 2009 | Int Orthop2009，33，5： | 1 |
| 20 | Etiologic study of ischemic stroke in young taiwan显示文摘 | Lee TH Hsu WC Chen CJ | 2002 | Stroke2002，，： | 1 |
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