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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Distribution of chlorophyll a,photosynthesis and their relations to the environmental factors in Central South China Sea显示文摘 | Chen Xingqun Chen Qihuan Zhuang Liangzhong | 1989 | Haiyang Xuebao1989，11，3： | 1 |
| 3 | Ecological characteristics of phytoplankton community from eutrophic waters in the Maluan Bay显示文摘I^IOWTheMaluanBayisashallowandmOStlyendedwatertheywhichisisolatedfromwesternXiamenhaforbyaseawall.Thebayhaslongbenboldingagreatdealofagriculturalandindustrialwaterandmunicipalsewage.Moreover,aquacultureindustryhasbeendeveloppedinal^aceinthebayinrecen... | Yang Qingliang Chen Qihuan Lin Jinmei Lin Gengrning and Chen Xingqun( Third institute of Oceanography, State Oceanic Administration, Xiamen 361005, China) | 1999 | Acta Oceanologica Sinica1999，18，4： | 1 |
| 4 | MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells显示文摘 | Junjie Xiao Dandan Liang Hong Zhang Ying Liu Dasheng Zhang Yi Liu Lei Pan Xiaoli Chen Pieter A. Doevendans Yunfu Sun Xingqun Liang Joost P.G. Sluijter Yi-Han Chen | 2012 | Journal of Molecular and Cellular Cardiology2012，，6： | 1 |
| 5 | Primary productivity in the western tropical Pacific and equatorial warm waters显示文摘Primary productivity in the western tropical Pacific and equatorial warm waters was studied in the WOCE cruise in November of 1991 and the TOGA-COARE cruise from November of 1992 to February of 1993.It is shown that the total amount of integrated chlorophyll a(chloro a)was 19 79 mg/m 2 in depthof0~150 m and the average daily primary productivity was 171 mg/(m 2·d)(C)appeared in the western tropical Pacific while a higher chloro a(21 68 mg/m 2)and primary productivity [228 mg/(m 2·d)(C)]were observed in the equatorial warm waters.The highest chloro a was found at the coastal stations of Philippines and Irian while the lowest chloro a was at the offshore areas bounded by 2°~4°N.The distribution pattern of chloro a biomass was related to different physical processes.Upwelling,which may have led to a high biomass, was a critical factor changing the distributions of temperature,salinity and nutrient in these areas. | Chen Xingqun 1,Zhang Ming 1,Chen Qihuan 1 ThirdInstituteofOceanography ,StateOceanicAdministration ,Xiamen 36 10 0 5 ,China | 2001 | Acta Oceanologica Sinica2001，20，1： | 1 |
| 6 | α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture显示文摘 | Farah Sheikh Yinghong Chen Xingqun Liang Alain Hirschy Antine E. Stenbit Yusu Gu Nancy D. Dalton Toshitaka Yajima Yingchun Lu Kirk U. Knowlton Kirk L. Peterson Jean-Claude Perriard Ju Chen | 2006 | Circulation2006，，10： | 1 |
| 7 | Chlorophyll a and primary production in the northeastern Pacific Ocean显示文摘The primary production and chlorophyll a concentration of picoplankton (0.2~2 μm),nanoplankton (2~20 μm) and microplankton (20~200 μm) are described in the northeastern Pacific Ocean near the Hawaii Islands during the six survey cruises from 1996 to 2003: DY85-4,DY95-7,DY95-8,DY95-10,DY105-11 and DY105-12.14. The primary production of carbon was in range from 76.8 to 191.9 mg/(m2 ·d) with an average of 116.1 mg/(m2·d) in the east region,and from 73.1 to 222.5 mg/(m2·d) with an average of 127.1 mg/(m2·d) in the west region,similar to the other oligotrophic regions of the Pacific Ocean investigated. The chlorophyll a concentration was about 0.1 mg/m3 from the surface to the 50 m depth,about 0.2~0.4 mg/m3 from 50 to 100 m,and gradually decreased below the 100 m depth. The picoplankton accounted for more than 70% of the total chlorophyll a in the upper layer (surface to 125 m),but it decreased to less than 50% in depth below 125 m. The nanoplankton and microplankton combined only accounted for less than 30% of the total chlorophyll a in the upper layer,but showed a more even vertical distribution. | CHEN Xingqun LIN Rongcheng | 2008 | Acta Oceanologica Sinica2008，27，1： | 1 |
| 8 | Distribution of Chlorophyll a and primary productivity in the neritic waters of Fujian Province显示文摘INTRODUCTIONThe coast zone is the area where most human activities take place and where the highest economic benefit is produced. The knowledge of the distribution and variation of primary production provides the bases as reference helping the marine exploitation and management. | Chen Qihuan, Chen Xingqun and Zhang Ming Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China | 1997 | Acta Oceanologica Sinica1997，16，1： | 0 |
| 9 | Study of monthly variations in primary production and their relationships with environmental factors in the Daya Bay based on a general additive model显示文摘In this study, the horizontal and vertical distribution of primary production(PP) and its monthly variations were described based on field data collected from the Daya Bay in January–December of 2016. The relationships between PP and environmental factors were analyzed using a general additive model(GAM). Significant seasonal differences were observed in the horizontal distribution of PP, while vertical distribution showed a relatively consistent unimodal pattern. The monthly average PP(calculated by carbon) ranged from 48.03 to 390.56 mg/(m^2·h),with an annual average of 182.77 mg/(m^2·h). The highest PP was observed in May and the lowest in November.Additionally, the overall trend in PP was spring>summer>winter>autumn, and spring PP was approximately three times that of autumn PP. GAM analysis revealed that temperature, bottom salinity, phytoplankton, and photosynthetically active radiation(PAR) had no significant relationships with PP, while longitude, depth, surface salinity, chlorophyll a(Chl a) and transparency were significantly correlated with PP. Overall, the results presented herein indicate that monsoonal changes and terrestrial and offshore water systems have crucial effects on environmental factors that are associated with PP changes. | KANG Jianhua HUANG Hao LI Weiwen LIN Yili CHEN Xingqun | 2018 | Acta Oceanologica Sinica2018，37，12： | 0 |
| 10 | Distribution of chlorophyll a, photosynthesis and their relations to the environmental factors in the Central South China Sea显示文摘Some studies have been made on the variation of primary productivity in the Central South ChinaSea. This paper studies comprehensively the characteristics of chlorophyll a distributions in time andspace and the primary productivity, as well their relations to the environmental factors.Materals and methods During the comprehensive investigation in the Central South China Sea from September 1983 toDecember 1984, the distributions of chlorophyll a and primary productivity were studied. Figure 1shows the sampling stations and their range of investigation. | Chen Xingqun, Chen Qihuan, Zhuang LiangzhongThird Institute of Oceanography, State Oceanic Administration, Xiamen, China | 1990 | Acta Oceanologica Sinica1990，9，4： | 0 |
| 11 | The distribution of chlorophyll a and its influencing factors in different regions of the Bering Sea显示文摘The distribution of chlorophyll a(Chl a) and its relationships with physical and chemical parameters in different regions of the Bering Sea were discussed in July 2010. The results showed the seawater column Chl a concentrations were 13.41–553.89 mg/m2 and the average value was 118.15 mg/m2 in the study areas. The horizontal distribution of Chl a varied remarkably from basin to shelf in the Bering Sea. The regional order of Chl a concentrations from low to high was basin, slope, outer shelf, inner shelf, and middle shelf. The vertical distribution of Chl a was grouped mainly from single-peak type in basin, slope, outer shelf, and middle shelf, where the deep Chl a maxima(DCM) layer was observed at 25–50 m, 30–35 m, 36–44 m, and 37–47 m, respectively. The vertical distribution of Chl a mainly had three basic patterns: standard single-peak type, surface maximum type, and bottom maximum type in the inner shelf. The analysis also showed that the transportation of ocean currents may control the distribution of Chl a, and the effects were not simple in the basin of the Bering Sea. There was a positive correlation between Chl a and temperature, but no significant correlation between Chl a and nutrients. The Bering Sea slope was an area deeply influenced by slope current. Silicate was the factor that controlled the distribution of Chl a within parts of the water in the slope. Light intensity was an important environmental factor in controlling seawater column Chl a in the shelf, where Chl a was limited by nitrate rather than phosphate within the upper water. Meanwhile, there was a positive relationship between Chl a and salinity. Algal blooms broke out at Sta. B6 of the southwestern St. Lawrence Island and Stas F6 and F11 in the middle of the Bering Strait. | KANG Jianhua CHEN Xingqun ZHANG Ming | 2014 | Acta Oceanologica Sinica2014，33，6： | 0 |
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