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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 3 | Nutritional value of high lysine corn for the broiler chick poultry science显示文摘 | CHI M S SPEERS G M | 1973 | Poultry Science1973，52，： | 1 |
| 4 | Beacon/ubiquitin- like-5 immunoreaetivity in the hypothalamus and pituitary of the mouse显示文摘 | BRAILOIU G C DUN S L CHI M | 2003 | Brain Research2003，984，： | 1 |
| 5 | Synthesis, characterization and liquid-crystal-aligning properties of novel aromatic polypyromellitimides bearing (n-alkyloxy)biphenyloxy side chains显示文摘 | Lee S B Shin G J Chi J H | 2006 | Polymer2006，47，19： | 1 |
| 6 | Clinical implications of non-A-type NPM1 and FLT3 mutations in patients with nor-mal karyotype acute myeloid leukemia显示文摘 | PARK G CHI H S PARK S J | 2012 | Acta Haematologi- ca2012，127，2： | 1 |
| 7 | Dry-contact and noncontact biopotential electrodes: methodological review 显示文摘 | Chi Y M Jung T P Cauwenberghs G | 2009 | IEEE Reviews in Biomedical Engineering2009，，3： | 1 |
| 8 | Recovery of Rare Earth from Bastnasite by Ammonium Chloride Roasting with Fluorine Deactivation显示文摘 | Chi R Zhang X Zhu G | 2004 | Miner Eng2004，17，910： | 1 |
| 9 | Determination of Four Microele- ments in CAULIS SPATHOLOBI from Guangdong and Guangxi and As- sessment of Its Health Risk 显示文摘 | CHI Y G LI Z Y HUANG A H | 2010 | Medicinal Plant2010，1，12： | 1 |
| 10 | High performance liquid chromatography determination of chlorophenols in water samples after preconcentration by continuous flow liquid membrane extraction on-line coupled with a precolunm 显示文摘 | Liu J F Liang X Chi Y G | 2003 | Analytica Chimica Acta2003，487，5： | 1 |
| 11 | Design of Lange-Couplers and Single-Sideband Mixers Using Micromachining Techniques显示文摘 | Rebeiz G M | 1997 | IEEE Microwave Theroy and Techniques1997，2，： | 1 |
| 12 | Studies on the relationship of structure-and properties of the polyesterurethanes adhesives 显示文摘 | Zhu Y Q Huang Y J Chi Z G | 1994 | Eur Polym J1994，30，12： | 1 |
| 13 | Synthesis and prop- erties of gelators derived from tetraphenylethylene and gallic acid with aggregation-induced emission显示文摘 | LUO M ZHOU X CHI Z G | 2013 | Jour- nal of Molecular and Engineering Materials2013，1，13： | 1 |
| 14 | Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart显示文摘 | Tamura Y Chi L G Driscoll E M | 1988 | Circ Res1988，63，5： | 1 |
| 15 | The molecular role of mast cells in atherosclerotic cardiovascular disease显示文摘 | Kelley JL Chi DS Abou-Auda W Smith JK Krishnaswamy G | 2000 | Mol Med Tod2000，6，： | 1 |
| 16 | Use of Ionic Liquids for Liquid-Phase Microextraction of Polycyclic Aromatic Hydrocarbons显示文摘 | Liu J F Jiang G B Chi Y G | 2003 | Anal Chem2003，75，21： | 1 |
| 17 | Safety, pharmacoki- netics, and efficacy of CPX-1 liposome injection in patients with advanced solid tumors 显示文摘 | BATIST G GELMON KA CHI KN | 2009 | Clin Cancer Res2009，15，2： | 1 |
| 18 | The relationship between interparen- tal conflict and adolescents' affective well-being: Media- tion of cognitive appraisals and moderation of peer status 显示文摘 | XIN Z CHI L YU G | 2009 | International Journal of Behavioral Development2009，33，5： | 1 |
| 19 | Hydrothermal dolomitization in the Lower Ordovician Romaine Formation of the Anticosti Basin:Significance for hydrocarbon exploration显示文摘 | Lavoie D Chi G Brennan-Alpert P | 2005 | Bulletin of Canadian Petroleum Geology2005，53，4： | 1 |
| 20 | Helicobaeter pylori infection and oncogene expressions in gastric carcinoma and precursor lesions显示文摘 | Wang J Chi D S Kalin G B | 2002 | Dig Dis Sci2002，4，7： | 1 |
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