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| 1 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 2 | Absolute calibration of HY-2A and Jason-2 altimeters for sea surface height using GPS buoy in Qinglan, China显示文摘GPS buoy methodology is one of the main calibration methodologies for altimeter sea surface height calibration. This study introduces the results of the Qinglan calibration campaign for the HY-2A and Jason-2 altimeters. It took place in two time slices;one was from August to September 2014, and the other was in July 2015. One GPS buoy and two GPS reference stations were used in this campaign. The GPS data were processed using the real-time kinematic (RTK) technique. The fi nal error budget estimate when measuring the sea surface height (SSH) with a GPS buoy was better than 3.5 cm. Using the GPS buoy, the altimeter bias estimate was about -2.3 cm for the Jason-2 Geophysical Data Record (GDR) Version ‘D' and from -53.5 cm to -75.6 cm for the HY-2A Interim Geophysical Data Record (IGDR). The bias estimates for Jason-2 GDR-D are similar to the estimates from dedicated calibration sites such as the Harvest Platform, the Crete Site and the Bass Strait site. The bias estimates for HY-2A IGDR agree well with the results from the Crete calibration site. The results for the HY-2A altimeter bias estimated by the GPS buoy were verifi ed by cross-calibration, and they agreed well with the results from the global analysis method. | CHEN Chuntao ZHU Jianhua ZHAI Wanlin YAN Longhao ZHAO Yili HUANG Xiaoqi YANG Weiwei | 2019 | Journal of Oceanology and Limnology2019，37，5： | 5 |
| 3 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 4 | Boron-doping induced lithophilic transition of graphene for dendrite-free lithium growth显示文摘Li metal,possessing advantages of high theoretical specific capacity and low electrochemical potential,is regarded as the most promising anode material for next-generation batteries.However,despite decades of intensive research,its practical application is still hindered by safety hazard and low Coulombic efficiency,which is primarily caused by dendritic Li deposition.To address this issue,restraining dendrite growth at the nucleation stage is deemed as the most effective method.By utilizing the difference of electronegativity between boron atoms and carbon atoms,carbon atoms around boron atoms in boron-doped graphene(BG)turn into lithiophilic sites,which can enhance the adsorption capacity to Li^(+)at the nucleation stage.Consequently,an ultralow overpotential of 10 mV at a current density of 0.5 mA/cm^(2) and a high average Coulombic efficiency of 98.54%over more than 140 cycles with an areal capacity of 2 mAh/cm^(2) at a current density of 1 m A/cm^(2) were achieved.BG-Li|LiFePO_(4) full cells delivered a long lifespan of480 cycles at 0.5 C and excellent rate capability.This work provides a novel method for rational design of dendrite-free Li metal batteries by regulating nucleation process. | Wei Liu Pengbo Zhai Shengjian Qin Jing Xiao Yi Wei Weiwei Yang Shiqiang Cui Qian Chen Chunqiao Jin Shubin Yang Yongji Gong | 2021 | Journal of Energy Chemistry2021，30，5： | 2 |
| 5 | Root exudates increased arsenic mobility and altered microbial community in paddy soils显示文摘Root exudates are crucial for plants returning organic matter to soils,which is assumed to be a major source of carbon for the soil microbial community.This study investigated the influence of root exudates on the fate of arsenic(As)with a lab simulation experiment.Our findings suggested that root exudates had a dose effect on the soil physicochemical properties,As speciation transformation and the microbial community structure at different concentrations.The addition of root exudates increased the soil pH while decreased the soil redox potential(Eh).These changes in the soil pH and Eh increased As and ferrous(Fe(Ⅱ))concentrations in soil porewater.Results showed that 40 mg/L exudates addition significantly increased arsenite(As(Ⅲ))and arsenate(As(Ⅴ))by 541 and 10 times respectively within 30 days in soil porewater.The relative abundance of Fe(Ⅲ)-reducing bacteria Geobacter and Anaeromyxobacter increased with the addition of root exudates,which enhanced microbial Fe reduction.Together these results suggest that investigating how root exudates affect the mobility and transformation of As in paddy soils is helpful to systematically understand the biogeochemical cycle of As in soil-rice system,which is of great significance for reducing the health risk of soil As contamination. | Ouyuan Jiang Lvyao Li Guilan Duan Williamson Gustave Weiwei Zhai Lina Zou Xia An Xianjin Tang Jianming Xu | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 6 | Equilibrium Phase Behavior of Ethylene Glycol/Glycerin+RbNO3/CsNO3+H2O at 288.15 and 298.15 K显示文摘 | ZHANG Huiying LI Shuni ZHU Weiwei ZHAI Quanguo JIANG Yucheng HU Mancheng | 2014 | Chemical Research in Chinese Universities2014，30，6： | 1 |
| 7 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 8 | Side force control on slender body by self-excited oscillation flag显示文摘Strong asymmetrical vortices appear on the leeward of slender body at high angles of attack,which has very unfavorable effect on the stability and control of the aircraft.A method is developed to control the side force of slender body at high angles of attack,and is verified in wind tunnel.A thin-film triangular self-excited oscillation flag is fixed at the tip of the slender body model whose semi-apex angle is 10°.Side force is approximately linearly proportional to roll-setting angle of self-excited oscillation flag at high angles of attack,and the slop of fitting straight line obtained by the least square method is-0.158.The linear relationship between side force and roll-setting angle provides convenience for developing side force control law of slender body at high angles of attack.Experimental data shows that the side force coefficients vary linearly with roll-setting angles when a specific plastic self-excited oscillation flag is used as the control flag.The range of side force coefficient and roll-setting angle are,respectively,-3.2to 3.0 and-20° to 20°.The device is simple,effective,and is of great potential in engineering application. | Jian Zhai Weiwei Zhang Chuanqiang Gao Yanhua Zhang Zhengyin Ye Huanling Wang | 2016 | Theoretical & Applied Mechanics Letters2016，6，5： | 1 |
| 9 | Identification and antioxidant activity of anthecyanim extracted from the seed and cob of purple corn (Zea mays L,)显示文摘 | YANG Zhendong ZHAI Weiwei | 2010 | Innovative Food Science and Emerging Technologies2010，11，1： | 1 |
| 10 | On the origin of SARS-CoV-2——The blind watchmaker argument显示文摘In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. | Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie Chen Zixiao Guo Yongsen Ruan Xuemei Lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 1 |
| 11 | Identification and antioxidant activity of anthocyanins extracted from the seed and cob of purple corn ( Zea mays L.)显示文摘 | Zhendong Yang Weiwei Zhai | 2009 | Innovative Food Science and Emerging Technologies2009，，1： | 1 |
| 12 | Facile preparation of lightweight microcellular polyetherimide/ graphene composite foams for electromagnetic interference shielding显示文摘 | Jianqiang Ling Wentao Zhai Weiwei Feng etc | 2013 | ACS Applied Materials & Interfaces2013，，5： | 1 |
| 13 | ISOLATION AND INDUCTION OF DIFFERENTIATION OF SEINE ADIPOSE-DERIVED MESENCHYMAL STEM CELLS显示文摘Objectives To establish a method for high yield mesenchymal stem cells collection,as well as a culture method for identifying mesenchymal stem cells from the swine adipose-derived mesenchymal stem cell(ADMSC).Methods Swine ADMSCs were isolated from fat tissue with collagenase,followed by induction of differentiation to osteogenic,adipogenic and chondrogrnic cells.The survival curve of the ADMSC at the 37oC and 38oC were measured using WST-1Cell Proliferation Assay Reagent.Result ADMSCs isolated with collagenase from swine neck fat tissue generated a stable uniform appearance after the second generation.The passage period was five days.ADMSC could differentiate into osteogenic,adipogenic or chondrogrnic cells under different culture conditions.The highest growth rate was achieved at 38oC in this study.Conclusion Swine ADMSCs have the potential to differentiate into osteogenic,adipogenic or chondrogrnic cells,and they may be appropriate for transplantation for both research and clinical purpose. | MA Yueying YUAN Shuolong ZHANG yue XU liangwei GUO Weiwei ZHAO Lidong ZHAI suoqiang YANG Shiming | 2014 | Journal of Otology2014，9，2： | 0 |
| 14 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 15 | On the epicenter of COVID-19 and the origin of the pandemic strain显示文摘Ruan et al.(2022)published in National Science Review(NSR)an analysis that concludes two early centers in the spread of COVID-19[1].Since the strain(referred to as DG1111)that spread globally to cause the pandemic has never been found in Wuhan prior to its arrival from outside Asia in March 2020. | Yongsen Ruan Haijun Wen Mei Hou Weiwei Zhai Shuhua Xu Xuemei Lu | 2023 | National Science Review2023，10，4： | 0 |
| 16 | Phylogenetic signal in gut microbial community rather than in rodent metabolic traits显示文摘Host phylogeny and environment have all been implicated in shaping the gut microbiota and host metabolic traits of mammals.However,few studies have evaluated phylogeny-associated microbial assembly and host metabolic plasticity concurrently,and their relationships on both short-term and evolutionary timescales.We report that the branching order of a gut microbial dendrogram was nearly congruent with phylogenetic relationships of seven rodent species,and this pattern of phylosymbiosis was intact after diverse laboratory manipulations.Laboratory rearing,diet or air temperature(Ta)acclimation induced alterations in gut microbial communities,but could not override host phylogeny in shaping microbial community assembly.A simulative heatwave reduced core microbiota diversity by 26%in these species,and led to an unmatched relationship between the microbiota and host metabolic phenotypes in desert species.Moreover,the similarity of metabolic traits across species at different Tas was not correlated with phylogenetic distance.These data demonstrated that the gut microbial assembly showed strong concordance with host phylogeny and may be shaped by environmental variables,whereas host metabolic traits did not seem to be linked with phylogeny. | Xue-Ying Zhang Saeid Khakisahneh Wei Liu Xinyi Zhang Weiwei Zhai Jilong Cheng John R.Speakman De-Hua Wang | 2023 | National Science Review2023，10，10： | 0 |
| 17 | Dynamics of a qubit—TLS system under resonant microwave driving显示文摘We demonstrate the effect of different coupling strengths between a microscopic two-level system(TLS)and a microwave field on the dynamics of a qubit—TLS system when the bipartite system is subject to resonant microwave driving.Rabi beating with a different TLSmicrowave coupling strength is demonstrated in simulations.Entanglement,quantified by the concurrence between the qubit and TLS,both for pure states and mixed states,is simulated.When decoherence is considered,entanglement of the bipartite system oscillates with damping and exhibits entanglement sudden death and/or entanglement sudden death and revival. | Jianxin Shi Weiwei Xu Guozhu Sun Jiquan Zhai Zhican Du Lin Wang Tao Hua Jian Chen Lin Kang Peiheng Wu | 2014 | Chinese Science Bulletin2014，59，21： | 0 |
| 18 | Ancient DNA reveals the maternal genetic history of East Asian domestic pigs显示文摘Zoo-archaeological and genetic evidence suggest that pigs were domesticated independently in Central China and Eastern Anatolia along with the development of agricultural communities and civilizations.However,the genetic history of domestic pigs,especially in China,has not been fully explored.In this study,we generate 42 complete mitochondrial DNA sequences from~7500-to 2750-year-old individuals from the Yellow River basin.Our results show that the maternal genetic continuity of East Asian domestic pigs dates back to at least the Early to Middle Neolithic.In contrast,the Near Eastern ancestry in European domestic pigs saw a near-complete genomic replacement by the European wild boar.The majority of East Asian domestic pigs share close haplotypes,and the most recent common ancestor of most branches dates back to less than 20,000 years before present,inferred using new substitution rates of whole mitogenomes or combined protein-coding regions.Two major population expansion events of East Asian domestic pigs coincided with changes in climate,widespread adoption of introduced crops,and the development of agrarian societies.These findings add to our understanding of the maternal genetic composition and help to complete the picture of domestic pig evolutionary history in East Asia. | Ming Zhang Yichen Liu Zhipeng Li Peng Lü Jacob D.Gardner Maolin Ye Jihuai Wang Miaomiao Yang Jing Shao Weilin Wang Qingyan Dai Peng Cao Ruowei Yang Feng Liu Xiaotian Feng Lizhao Zhang Enwei Li Yunzheng Shi Zehui Chen Shilun Zhu Weiwei Zhai Tao Deng Ziyuan Duan E.Andrew Bennett Songmei Hu Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 19 | Delineating the longitudinal tumor evolution using organoid models显示文摘Cancer is an evolutionary process fueled by genetic or epigenetic alterations in the genome.Understanding the evolutionary dynamics that are operative at different stages of tumor progression might inform effective strategies in early detection,diagnosis,and treatment of cancer.However,our understanding on the dynamics of tumor evolution through time is very limited since it is usually impossible to sample patient tumors repeatedly.The recent advances in in vitro 3D organoid culture technologies have opened new avenues for the development of more realistic human cancer models that mimic many in vivo biological characteristics in human tumors.Here,we review recent progresses and challenges in cancer genomic evolution studies and advantages of using tumor organoids to study cancer evolution.We propose to establish an experimental evolution model based on continuous passages of patient-derived organoids and longitudinal sampling to study clonal dynamics and evolutionary patterns over time.Development and integration of population genetic theories and computational models into time-course genomic data in tumor organoids will help to pinpoint the key cellular mechanisms underlying cancer evolutionary dynamics,thus providing novel insights on therapeutic strategies for highly dynamic and heterogeneous tumors. | Zhaolian Lu Beina Nie Weiwei Zhai Zheng Hu | 2021 | Journal of Genetics and Genomics2021，48，7： | 0 |
| 20 | Population genomic analysis reveals distinct demographics and recent adaptation in the black flying fox(Pteropus alecto)显示文摘As the only mammalian group capable of powered flight,bats have many unique biological traits.Previous comparative genomic studies in bats have focused on long-term evolution.However,the microevolutionary processes driving recent evolution are largely under-explored.Using resequencing data from 50 black flying foxes(Pteropus alecto),one of the model species for bats,we find that black flying fox has much higher genetic diversity and lower levels of linkage disequilibrium than most of the mammalian species.Demographic inference reveals strong population fluctuations(>100 fold)coinciding with multiple historical events including the last glacial change and Toba super eruption,suggesting that the black flying fox is a very resilient species with strong recovery abilities.While long-term adaptation in the black flying fox is enriched in metabolic genes,recent adaptation in the black flying fox has a unique landscape where recently selected genes are not strongly enriched in any functional category.The demographic history and mode of adaptation suggest that black flying fox might be a well-adapted species with strong evolutionary resilience.Taken together,this study unravels a vibrant landscape of recent evolution for the black flying fox and sheds light on several unique evolutionary processes for bats comparing to other mammalian groups. | Haopeng He Hechuan Yang Randy Foo Wharton Chan Feng Zhu Yunsong Liu Xuming Zhou Liang Ma Lin-Fa Wang Weiwei Zhai | 2023 | Journal of Genetics and Genomics2023，50，8： | 0 |
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