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| 1 | Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease显示文摘Utilization of mesenchymal stromal cells(MSCs) for the treatment of Crohn's disease and ulcerative colitis is of translational interest.Safety of MSC therapy has been well demonstrated in early phase clinical trials but efficacy in randomized clinical trials needs to be demonstrated.Understanding MSC mechanisms of action to reduce gut injury and inflammation is necessary to improve current ongoing and future clinical trials.However, two major hurdles impede the direct translation of data derived from animal experiments to the clinical situation:(1) limitations of the currently available animal models of colitis that reflect human inflammatory bowel diseases(IBD).The etiology and progression of human IBD are multifactorial and hence a challenge to mimic in animal models; and(2) Species specific differences in the functionality of MSCs derived from mice versus humans.MSCs derived from mice and humans are not identical in their mechanisms of action in suppressing inflammation.Thus, preclinical animal studies with murine derived MSCs cannot be considered as an exact replica of human MSC based clinical trials.In the present review, we discuss the therapeutic properties of MSCs in preclinical and clinical studies of IBD.We also discuss the challenges and approaches of using appropriate animal models of colitis, not only to study putative MSC therapeutic efficacy and their mechanisms of action, but also the suitability of translating findings derived from such studies to the clinic. | Raghavan Chinnadurai Spencer Ng Vijayakumar Velu Jacques Galipeau | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats显示文摘Objective:To investigate the protective role of Cardiospermum halicacabum(C.halicacabum) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic rats.Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ.The C.halicacabum leaf extract(CHE) was administered orally to normal and STZ-diabetic rats for 45 days.The effects of C.halicacabum leaf extract(CHE) on plasma and tissue glycoproteins (hexose,hexosamine,fucose and sialic acid) were determined.Results:The levels of plasma and tissues glycoproteins containing hexose,hexosamine and fucose were significantly increased in STZ-induced diabetic rats.In addition,the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats.After administration of CHE to diabetic rats,the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity. | Chinnadurai Veeramani Khalid S Al-Numair Mohammed A Alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 2 |
| 3 | Larvicidal activity of green synthesized silver nanoparticles using bark aqueous extract of Ficus racemosa against Culex quinquefasciatus and Culex gelidus显示文摘Objective:To investigate the larvicidal activity of synthesized silver nanoparticles(Ag NPs) utilizing aqueous bark extract of Ficus racemosa(F.racemosa) was tested against fourth instar larvae of filariasis vector,Culex quinquefasciatus(Cx.quinquefasciatus) and japanese encephalitis vectors,Culex gelidus(Cx.gelidus).Methods:The synthesized Ag NPs was characterized by UV-vis spectrum,X-ray diffraction(XRD),Scanning electron microscopy(SEM) and Fourier transform infrared(FTIR).The larvicidal activities were assessed for 24 h against the larvae of Cx.quinquefasciatus and Cx.gelidus with varying concentrations of aqueous bark extract off.racemosa and synthesized Ag NPs.LC50 and r2 values were calculated.Results:The maximum efficacy was observed in crude aqueous extract of F.racemosa against the larvae of Cx.quinquefasciatus and Cx.gelidus(LC50=67.72 and 63.70 mg/L;r2=0.995 and 0.985) and the synthesized Ag NPs(LC50=12.00 and 11.21 mg/L;r2=0.997 and 0.990).respectively.Synthesized Ag NPs showed the XRD peaks at 2θvalues of 27.61,29.60,35.48,43.48 and 79.68 were identified as (210),(121),(220),(200) and(311) reflections,respectively.The FTIR spectra of Ag NPs exhibited prominent peaks at 3 425,2 878,1 627 and 1 382 in the region 500-3 000 cm-1.The peaks correspond to the presence of a stretching vibration of(NH) C=O group.SEM analysis showed shape in cylindrical,uniform and rod with the average size of 250.60 nm.Conclusions:The biosynthesis of silver nanoparticles using bark aqueous extract of F.racemosa and its larvicidal activity against the larvae of disease spreading vectors.The maximum larvicidal efficacy was observed in the synthesized Ag NPs. | Kanayairam Velayutham Abdul Abdul Rahuman Govindasamy Rajakumar Selvaraj Mohana Roopan Gandhi Elango Chinnaperumal Kamaraj Sampath Marimuthu Thirunavukkarasu Santhoshkumar Moorthy Iyappan Chinnadurai Siva | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 4 | Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa显示文摘Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(C.gigantea)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(H.bispinosa).Methods:The lyophilized C.gigantea flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 h.Synthesized TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of H.bispinosa were exposed to filter paper impregnated method.Results:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 nm.The functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for C-O.SEM micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in shape.The maximum efficacy was observed in the aqueous flower extract of C.gigantea and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against H.bispinosa(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).respectively.Conclusions:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of H.bispinosa.This study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity. | Sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai Siva Loganathan Karthik Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 2 |
| 5 | BH3 - only proteins in apoptosis and beyond : an overview 显示文摘 | Lomonosova E Chinnadurai G | 2008 | Oncogene2008，1，： | 1 |
| 6 | BH3 - only proteins in apoptosis and beyond : an overview显示文摘 | Lomonosova E Chinnadurai G | 2008 | Oncogene2008，27，1： | 1 |
| 7 | Critical requirement of BAX tbr manifestation of apoptosis induced by muhiple stimuli in human epithelial cancer cells显示文摘 | Theodorakis P Lomonosova E Chinnadurai G | 2002 | Cancel' Res2002，62，12： | 1 |
| 8 | Bfl- 1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity显示文摘 | D'Sa-Eipper C Subramanian T Chinnadurai G | 1996 | Cancer Res1996，56，17： | 1 |
| 9 | Antihyperglycaemic effect ofCardiospermum halicacabum Linn, leaf extract on STZ-induced diabetic rats 显示文摘 | Chinnadurai Veeramani Ganesan Pushpavalli KodukkurViswanathan Pugalendi | 2008 | J Appl Biomed2008，6，： | 1 |
| 10 | Adenovirus E1A as a tumor-suppressor gene显示文摘 | Chinnadurai G | 1992 | Oncogene1992，7，7： | 1 |
| 11 | Optimizing a nitrogen-supplemented, condensed corn soluble medium for growth of the Polyhydroxyalkanoate producer Pseudomonas putida KT217显示文摘Pseudomonas putida KT217 produces medium-chain-length polyhydroxyalkanoate(mcl-PHA)that is of commercial interest as a biodegradable plastic.To reduce PHA production costs,a less expensive medium to grow P.putida KT217 to a high cell dry weight(CDW)was developed.P.putida KT217 was grown in aerated shake flasks on a condensed corn solubles(CCS)based medium that provided several organic acids and carbohydrates that were utilized for growth.The medium was prepared by adding various amounts of fresh CCS(100-600 g/L,or 34.9-209.4 g/L dry basis)to water and then centrifuging and filtering.The CCS permeate media contained dry matter levels of 28.8-164.9 g/L.The CCS permeate medium containing 108.4 g/L solids produced approximately 6 g CDW/L,at a growth rate of 1.03 per hour,and maximum cell population of 4×109 CFU/mL.Because CCS is low in nitrogen,ammonium hydroxide was added at a level of 1.73 g/L,and this significantly increased the CDW(>20 g/L)produced in an aerated bioreactor.Therefore,a nitrogen supplemented CCS medium could provide a cheap source of nutrients for production of P.putida KT217 and PHA. | Jeremy Javers William Gibbons Chinnadurai Karunanithy | 2012 | International Journal of Agricultural and Biological Engineering2012，5，4： | 1 |
| 12 | BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions 显示文摘 | Chinnadurai G Vijayalingam S Gibson SB | 2008 | Oncogene2008，27，1： | 1 |
| 13 | Bik, a noval death-inducing proteinshares a disdinct sequence motif with Bcl-2 family proteins and interacts with viral andcellular survival-promoting protein 显示文摘 | Boyd JM Gallo GJ Elangovan B Houghton AB Malstrom S Avery BJ Ebb RG Subramanian T Chittenden T Lutz RJ Chinnadurai G | 1995 | Oncogene1995，11，4： | 1 |
| 14 | Adenovirus E1A as a tumor-suppressor gene显示文摘 | Chinnadurai G | 1992 | Oncogene1992，7，7： | 1 |
| 15 | Transcriptional regulation by C-terminal binding proteins显示文摘 | CHINNADURAI G | 2007 | International] oumal of Biochemistry & Cell Biology2007，39，9： | 1 |
| 16 | CtBP,an unconventional transcriptional corepressor in development and oncogenesis显示文摘 | CHINNADURAI G | 2002 | Mol Cell2002，9，2： | 1 |
| 17 | CtBP,an unconventional transcriptional corepressor in development and oncogenesis显示文摘 | Chinnadurai G | 2002 | Mol Cell2002，9，： | 1 |
| 18 | Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1Tat protein显示文摘 | Kamine J Subramanian T Chinnadurai G | 1991 | Proc Natl Acad Sci USA1991，88，19： | 1 |
| 19 | BH3-Only proteins in apoptosis and beyond: an overview 显示文摘 | Lomonosova E Chinnadurai G | 2008 | Oncogene2008，27，1： | 1 |
| 20 | Critial requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cell显示文摘 | Theodorakis P Lomomosova E Chinnadurai G | 2000 | Cancer Res2000，62，12： | 1 |
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