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606篇 您的检索式:作者名="CHRISTI A"
    题名 作者 年代 出处 被引量
1Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns 2015World Journal of Gastroenterology2015,21,17:4
2Baterial endophytes: Potential role in developing sustainable systems of crop production显示文摘Sturz A V Christie B R Nowak J 2000Critical Reviews in Plant Sciences2000,19,1:1
3Elec- tricity generation from cellulose by rumen microorganisms in microbial fuel cells显示文摘Rismani-Yazdi H Christy A D Dehority B A 2007Biotechnol Bioeng2007,97,:1
4Selection of new Kynarbased electrolytes for lithium-ion batteries显示文摘Christie A M Christie L Vincent C A 1998J Power Sources1998,74,1:1
5Maturity determination of organic matter in coals using the methylphenanthrene distribution显示文摘Kvalhem O M Christy A A Telnaes N 1987Geochimica et Cosmochimica Acta1987,51,7:1
6Comparisons of empirical viscous-fingering models and their calibration for heterogeneous problems 显示文摘Fayers F J Blunt M J Christie M A 1992SPE 221841992,,:1
7Soil solution Zn and pH dynamics in nonrhizosphere soil and in the rhizosphere of Thlaspi caerulescens grown in a Zn/Cd contaminated soil 显示文摘Luo Y M Christie P Baker A J M 2000Chemosphere2000,41,:1
8Association of CCR5 delta32 with reduced risk of asthma 显示文摘Hall IP Wheatley A Christie G 1999Lancet1999,354,9186:1
9The stochastic behavior of common stock variances显示文摘Christie A A 1982Journal of Financial Economics1982,10,:1
10Epitope based recombinant BCG vaccine elicits specific Thl polarized immune responses in BALB/c mice显示文摘Christy A J Dharman K Dhandapaani G 2012Vaccine2012,30,13:1
11The use of lightweight expanded clay aggregate (LECA) as sorbent for PAHs removal from water 显示文摘Nkansah M A Christy A A Barth T 2012Journal of Hazardous Materials2012,,:1
12Mechanisms of remodeling in asthmatic airways显示文摘Shifren A Witt C Christie C 2012J Allergy(Cairo)2012,2012,31:1
13Decentralization of the firm:theory and evidence显示文摘CHRISTIE A A JOYE M P WATTS R L 2003Journal of Corporate Finance2003,9,1:1
14Flavonoid supplement improves leg health and reduces fluid retention in pre-menopausal women in a double-b/ind, placebo-controlled study显示文摘CHRISTIE S WALKER A F HICKS S M 2004Phytomexiicine2004,11,1:1
15Bacterial endophytes: po- tential role in developing sustainable systems of crop production 显示文摘STURZ A V CHRISTIE B R NORWAK J 2000Crit Rev Plant Sci2000,19,1:1
16Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal显示文摘Jaworowshi A Wilson NJ Christy E 1999J Biol Chem1999,272,15:1
17Correlating Nanoscale Titania Structure with Toxicity:A Cytotoxicity and Inflammatory Response Study with Human Dermal Fibroblasts and Human Lung Epithelial Cells显示文摘Christie Sayes Rajeev Wahi Preetha A 2006Toxicological sciences2006,92,1:1
18Nanomedicine: current status and future prospects显示文摘S Moein Moghimi A Christy Hunter J Clifford Murray 2005The FASEB Journal2005,19,:1
19New subtype of salmonid alphavirus (SAV), Togaviridae, from Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss in Norway 显示文摘Hodneland K Bratland A Christie K E 2005Dis Aquat Org2005,66,2:1
20Transforming growth factor-beta I : a possible signal molecule for posthemorrhagic hydrocephalus显示文摘Whitelaw A Christie S Pople 1 1999PediatrRes1999,46,5:1
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