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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Development,cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | | 0，，09： | 1 |
| 3 | Diagnostic utility of p16INK4a:a reappraisal of its use in cervical biopsies显示文摘 | Mulvany NJ Allen DG Wilson SM | 2008 | Pathology2008，40，4： | 1 |
| 4 | Structural basis of immune recognition of influenza virus hemagglutinin显示文摘 | WILSON IA COX NJ | 1990 | Annu Rev Immunol1990，8，： | 1 |
| 5 | Percutaneous closure of post-myocardial infarction ventricular septal defects: a single centre experience 显示文摘 | Ahmed J Ruygrok PN Wilson NJ | 2008 | Heart Lung Circ2008，17，2： | 1 |
| 6 | Novel insight into the control of litter size in plgs,using placental efficiency as a selection tool显示文摘 | WILSON ME BIENSEN NJ FORD SP | 1999 | Jour- nal of animal science1999，77，： | 1 |
| 7 | Diagnostic utility of p16INK4a:a reappraisal of its use in cervical biopsies显示文摘 | Mulvany NJ Allen DG Wilson SM | | 0，，04： | 1 |
| 8 | Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal显示文摘 | Jaworowshi A Wilson NJ Christy E | 1999 | J Biol Chem1999，272，15： | 1 |
| 9 | Development, cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Nat Immunol2007，8，9： | 1 |
| 10 | Structural basis of immune recognition of in fluenza virus hemagglutinin 显示文摘 | Wilson IA Cox NJ | 1990 | Annu Rev Imnmnol1990，8，： | 1 |
| 11 | Development, cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Natimmunol2007，8，9： | 1 |
| 12 | Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients 显示文摘 | Owens DW Wilson NJ Hill AJ | 2004 | J Cell Sci2004，117，8： | 1 |
| 13 | Structural basis of immune recognition of influenza virus hemagglutinin 显示文摘 | Wilson IA Cox NJ | 1990 | Annu Rev Immunol1990，8，： | 1 |
| 14 | IL-12 and IL-23: master regulators of immate and adaptive immunity显示文摘 | Langrish CL Mckenzie BS Wilson NJ | 2004 | J Immunol Rev2004，202，： | 1 |
| 15 | Increased sympathetic re- sponse to standing in panic disorder 显示文摘 | Coupland NJ Wilson SJ Potokar JP | 2003 | Psychiatry Res2003，118，1： | 1 |
| 16 | CT and MR imaging features of intrac-erebral epidermoid–a rare lesion显示文摘 | Aaribandi M Wilson NJ | | 0，，963： | 1 |
| 17 | Synthesis and biological evaluation of substituted 2-anilino-7H-pyrrolopyrimidines as PDK1 inhibitors 显示文摘 | O′brien NJ Brzozowski M Wilson DJD | 2014 | Tetrahedron2014，70，33： | 1 |
| 18 | Development,cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Nat Immunol2007，8，9： | 1 |
| 19 | Development,cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan J R | 2007 | Nature immunology2007，8，9： | 1 |
| 20 | Development cytokine profile and function of human interleukin 17- producing helper T cells 显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Nat Immunol2007，8，9： | 1 |
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