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| 1 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 2 | Phase -transfer catalytic determination of phenols as methylated derivatives by gas chromatography with flame ionization and massselective detection显示文摘 | Fiamegos Yiannis C Nanos Christos G Pilidis George A | 2003 | Journal of Chromatography A2003，1183，12： | 1 |
| 3 | Erythromycin as aProkinetic A gent in Perterm Infants显示文摘 | Christos C Anthony G Evarhalo E | 2002 | J Pediatr Gastroen-terol Nutr2002，34，1： | 1 |
| 4 | Deterministic adaptive control based on Laguerre series representation显示文摘 | CHRISTOS C Z DUMOUT G A | 1988 | Int J Control1988，48，6： | 1 |
| 5 | Laguerre based adaptive control of pH in bleach plant extraction stage显示文摘 | DUMOUT G A CHRISTOS C | 1990 | Automatica1990，26，4： | 1 |
| 6 | Consensus decision making in human crowds 显示文摘 | Johnr G Dyer Christos C Ioan-Nou Lesley J Morrell | 2008 | Animal behaviour2008，75，2： | 1 |
| 7 | Evaluation of porous silicon carbide monolithic honeycombs as volumetric receivers collectors of con- centrated solar radiation 显示文摘 | Christos C Athanasios G | 2007 | Solar Energy Materials and Solar Cells2007，91，6： | 1 |
| 8 | Erythromycin for feed intolerance in preterm neonate:a randomized,controlled trial显示文摘 | Christos C Anthony G Evangelic V | 1999 | Pediatric Res1999，45，： | 1 |
| 9 | Modeling, analysis, and optimal control of a class of hybrid systems显示文摘 | DAVID L P CHRISTOS G C | 1998 | Discrete Event Dy-namic Systems: Theory and Applications1998，7，2： | 1 |
| 10 | Statistical analysis and simulation of indoor single-phase low voltage power-line communication channels on the basis of multi-path propagation 显示文摘 | Ioannis C Papaleonidopoulos Christos N Capasalis Constantinos G Karagiannopolos | 2003 | IEEE Transaction on Consumer Electronics2003，49，1： | 1 |
| 11 | Dissipative Solutions显示文摘 | VELARDE M G | 1995 | Physica D1995，86，： | 1 |
| 12 | A sample path approach for solving the ground-holding policy problem in air traffic control 显示文摘 | Christos G P Christos G C | 2001 | IEEE Transactions on Control Systems Technology2001，9，3： | 1 |
| 13 | Optimal routing and energy allocation for lifetime maximization of wireless sensor networks with nonideal batteries显示文摘 | Christos G C Tao W Sepideh P | 2014 | IEEE Transactions on Control of Network Systems2014，1，1： | 1 |
| 14 | Erythronycin as a rrokinetic agent in preterm infants显示文摘 | CHRISTOS C ANTHONY G EVANGELIA V | 2002 | J Pediatr Gastroenterol Nutr2002，34，1： | 1 |
| 15 | Computer-assisted Imaging to Assess Brain Structure in Healthy and Disea- sed Brain显示文摘 | John A John G C Christos D | 2003 | The Lancet Neurology2003，2，2： | 1 |
| 16 | Thyroid autoimmunity and miscarriages: The corpus luteum hypothesis显示文摘 | Konstantinos A Toulis Dimitrios G Goulis Christos A Venetis Efstratios M Kolibianakis Basil C Tarlatzis Ioannis Papadimas | 2009 | Medical Hypotheses2009，，6： | 1 |
| 17 | Deterministic Adative Control Based on Laguerre Series Representation显示文摘 | Christos C Zerovos Dumout G A | 1988 | Int J Control1988，48，6： | 1 |
| 18 | An iron (Ⅲ) selective dendrite chelator based on polyamidoamine dendrimer modified with 4-bromo-1,8-naphthalimide显示文摘 | Christo P Ivo G Jean-Marc C | 2008 | Spectrochimica Acta (Part A)2008，69，： | 1 |
| 19 | Laguerre-based Adaptive Control of pH in Bleach Plant Extration Stage显示文摘 | Dumout G A Christos C Zervos at al | 1990 | Automation1990，26，4： | 1 |
| 20 | Deterministic adaptive control based on Laguerre series representation显示文摘 | CHRISTOS C ZEROVOS DUMOUT G A | 1988 | Int J Control1988，48，6： | 1 |
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