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| 1 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 2 | The availability of universal grammar to adult and child learners-a study of the acquisition of German word order显示文摘 | Clahsen H Muysken P | 1986 | Second Language Research1986，22，： | 1 |
| 3 | Parsing strategies in L1 and L2 sentence processing:A study of relative clause attachment in Greek显示文摘 | CLAHSEN H | 2003 | Studies in Second Language Acquisition2003，25，4： | 1 |
| 4 | Children's processing of ambiguous sentences:A study of relative clause attachment显示文摘 | MARINIS T CLAHSEN H | 2003 | Language Acquisition2003，11，： | 1 |
| 5 | Cell survival following B-ACL-B allograft transplantation: DNA finger prints, segregation, and morphological analysis of multiple markers in the canine model显示文摘 | Goertzen B J Buitkamp J Clahsen H | 1998 | Arch Orthop Trauma Surg1998，117，45： | 1 |
| 6 | Stability of human bone cortex following various preservation and sterilization methods显示文摘 | Jerosek J Muchow H Clahsen H | 1991 | 1 Orthop InreGrenzgeb1991，129，4： | 1 |
| 7 | High local recurrence risk after breast-conserving therapy in node-negative premenopau,sal breast cancer patients is gready reduced by one course of perioperative chemotherapy: A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study 显示文摘 | Elkhuizen P H van Slooten H J Clahsen P C | 2000 | J Clin Oncol2000，18，5： | 1 |
| 8 | High local recurrence risk after breast-conserving therapy in node-negative premenopausal breast cancer patients is greatly reduced by one course of perioperative chemotherapy: A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study 显示文摘 | Elkhuizen PH van Slooten H J Clahsen PC | 2000 | J Clin Oncol2000，18，5： | 1 |
| 9 | Continuity and shallow structures in language processing显示文摘 | Clahsen Harald & Felser C | 2006 | Applied Psycholinguistics2006，，27： | 1 |
| 10 | Cell survival following bone anterior erueiate ligament bone all graft transplantation:DNA finger prinit,segyegation,and allagen morphologieal analysis of multiple markers in the canine model显示文摘 | Goertzen MJ Buitkam PJ Clahsen H | 2005 | Arch Orthop trauma Surg2005，117，45： | 1 |
| 11 | How native-like is non-native language processing显示文摘 | CLAHSEN H FELSER C | | 0，，12： | 1 |
| 12 | Stability of human bone cortex following various preservation and sterilization meth- ods 显示文摘 | Jerosch J Muchow H Clahsen H | 1991 | Z Orthop Ihre Grenzgeb1991，129，4： | 1 |
| 13 | Morphologically complex words in L1 and L2 processing: evidence from masked priming experiments in English显示文摘 | Silva R Clahsen H | 2008 | Bilingualism: Language and Cognition2008，11，： | 1 |
| 14 | Grammatical processing in first and second language learners 显示文摘 | Clahsen H Felser C | 2006 | Applied Psycholinguistics2006，，27： | 1 |
| 15 | p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer 显示文摘 | CLAHSEN P C VANDE VELDE C J DUVA L | 1998 | J Clin Oncol1998，16，2： | 1 |
| 16 | Overview of randomized perioperative polychemotherapy trials in women with earlystage breast cgncer显示文摘 | Clahsen PC van de Velde CJ Goldhirseh A | 1997 | J Clin Oncol1997，15，7： | 1 |
| 17 | How native-like is non-native language processing显示文摘 | Clahsen H Felser C | 2006 | Trends in Cognitive Sciences2006，10，12： | 1 |
| 18 | Morphology, frequency, and the processing of derived words in native and non-native speakers显示文摘 | Clahsen H Neubauer K | 2010 | Lingua2010，120，19： | 1 |
| 19 | Lexical entries and rules of language: A multidisci- plinary study of German inflection显示文摘 | Clahsen H | 1999 | Behavioral & Brain Sci- ences[J]1999，22，6： | 1 |
| 20 | Expression of bcl-2 in Node-begative Breast Cancer is Associated With Various Prognostic Facters,But Dose not Predict Response to One Course of Perioperative Chemotherapy显示文摘 | SLOOTRN H J CLAHSEN P C DIERENDONCK J H | 1996 | Br J Cancer1996，74，1： | 1 |
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