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| 1 | CALUX生物学检测二噁方法在环境流行病学调查中的应用显示文摘目的探讨Chemically-ActivatedLuciferaseeXpression(CALUX)生物学方法作为检测二的一种方法在环境流行病学调查中的实用性。方法分别采用高分辨率气相色谱和质谱仪联机(HRGC-MS)法和CALUX方法测定同一来源的人体脂肪、血液和母乳中二毒性当量,观察两种不同方法测定结果间的相关性。结果两种方法测定脂肪组织和母乳中二毒性当量结果之间的相关系数分别为0.8675和0.9581,具有显著的正相关关系(P<0.05)。二毒性当量>20pg/gfat的血液样品,两种方法测定结果之间也具有密切的相关关系(P<0.05或<0.01)。结论CALUX生物学方法可适用于一般人群的脂肪组织和乳汁样品以及二类暴露人群的血液中二类污染物的筛查。 | 金一和 陈慧池 唐慧君 金秀花 刘惠芳 李珍 香山不二雄 滨松昌彦 匂坂馨 Brown D Clark G 中村昌文 | 2003 | 环境与健康杂志2003，20，3： | 6 |
| 2 | The gene for an abundant parasite coat protein predicts tandemly repetitive mental binding domains 显示文摘 | Clark T G Lin Tian-Long Jackwood D A | 1999 | Gene1999，229，： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Fate of metals in waste combustion systems 显示文摘 | Barton R G Clark W D Seeker W R | 1990 | Combustion Science and Technology1990，74，： | 1 |
| 5 | A novel integrated in vitro maturation and in vitro fertilization system for swine显示文摘 | Clark S G Walters E M Beebe D J | 2003 | Theriogenology2003，59，： | 1 |
| 6 | Measuring thermal and mechanical stresses on optical fiber in a DC module using fiber Bragg gratings显示文摘 | Glaesemann G S Smith J A Clark D A | 2005 | Journal of Lightwave Technology2005，23，11： | 1 |
| 7 | Surface analysis of MF-aluminas and related supported reagents by scanning electron microscopy显示文摘 | T Ando J H Clark D G Cork | 1986 | Bull Chem Soc1986，59，10： | 1 |
| 8 | Micrometastases in esophagogastric cancer:high detection rate in resected rib segments显示文摘 | O'SULLIVAN G C SHEEHAN D CLARKE A | 1999 | Gastroenterology1999，116，3： | 1 |
| 9 | Provision point mechanisms and field validity tests of contingent valuation 显示文摘 | Poe G Clark J Rondeau D | 2002 | Environmental and Resource Economics2002，23，： | 1 |
| 10 | High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term 显示文摘 | HENDERSON-SMART D J DE PAOLI A G CLARK R H | 2009 | Cochrane Database Syst Rev2009，3，00： | 1 |
| 11 | Human breast cancer correlation of relapse and survival with amplification of the HER-2/nen oncogene显示文摘 | Slamon D Clark G Wong S | 1987 | Science1987，235，4875： | 1 |
| 12 | Evaluation of the antidiabetic activity of DPP Ⅳ resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide显示文摘 | IRWIN N CLARKE G C GREEN B D | 2006 | Biochem Pharmacol2006，72，6： | 1 |
| 13 | Spontaneous spi- nal epidural Hematoma causing paraplegia : resolution and recovery without surgical decompression 显示文摘 | CLARKE D B BERTRAND G TAMPIERI ID | 1992 | Neurosurgery1992，30，1： | 1 |
| 14 | Existing knowledge,knowledge creation capability,and the rate of new product introduction in high-technology firms显示文摘 | Smith K G Collins C J Clark K D | | 0，，02： | 1 |
| 15 | Invasive phy- tophagous pests arising through a recent evolutionary radiation: theBaetrocera dorsalis complex of tropical fruit flies显示文摘 | CLARKE A R ARMSTRONG K F CARMICHAEL A E MILNE J R RAGHU S RODERICK G K YEATES D K | 2005 | Annual Review of Entomology2005，50，： | 1 |
| 16 | Butyricin 7423:a bacteriocin produced by Clostridium bulyricum NCIB 7423显示文摘 | Clarke D J Morris J G | 1976 | J Gen Microbiol1976，95，1： | 1 |
| 17 | Human breast cancer:correlation of relapse and survival with amplification of the HER-2/neu oncogene显示文摘 | SLAMON D J CLARK G M WONG S G | 1987 | Science1987，235，4785： | 1 |
| 18 | Evolution of genes andgenomes on the Drosophila phylogeny显示文摘 | Clark A G Eisen M B Smith D R | 2007 | Nature2007，，： | 1 |
| 19 | The Chitranjan Ranawat Award:Periarticular injections and femoral&sciatic blocks provide similar pain relief after TKA:a randomized clinical trial显示文摘 | Spangehl M J Clarke H D Hentz J G | 2015 | Clin Orthop Relat Res2015，473，1： | 1 |
| 20 | amifositine reduces side effects and improves complete response rale during radiotherapy:esults sf meta-analysis显示文摘 | Sasse A D Clark L G Sasse E C | 2006 | Int J Radiat Oncol Biol Phys2006，64，3： | 1 |
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