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| 1 | Healing of duodenal ulcer after eradication of Helicobacter heilmannii显示文摘 | Andrew F Goddard Robert PH Logan John C Atherton David Jenkins Robin C Spiller | 1997 | The Lancet1997，，9068： | 2 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 4 | Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation显示文摘 | Stephen Foley Klara Garsed Gulzar Singh Nathalie P. Duroudier Caroline Swan Ian P. Hall Abed Zaitoun Andrew Bennett Charles Marsden Geoffrey Holmes Andrew Walls Robin C. Spiller | 2011 | Gastroenterology2011，，5： | 2 |
| 5 | Serotonin and GI clinical disorders显示文摘 | Robin Spiller | 2008 | Neuropharmacology2008，，6： | 2 |
| 6 | Role of infection in irritable bowel syndrome显示文摘 | Robin C. Spiller | 2007 | Journal of Gastroenterology2007，，17： | 1 |
| 7 | Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system显示文摘 | John M Hebden Clive G Wilson Robin C Spiller | 1999 | Pharm Res1999，16，7： | 1 |
| 8 | Regional Differences in Quinine Absorption from the Undisturbed Human Colon Assessed Using a Timed Release Delivery System显示文摘 | John M. Hebden Clive G. Wilson Robin C. Spiller Peter J. Gilchrist Elaine Blackshaw Malcolm E. Frier Alan C. Perkins | 1999 | Pharmaceutical Research1999，，7： | 1 |
| 9 | Potential Biomarkers显示文摘 | Robin C. Spiller | 2011 | Gastroenterology Clinics of North America2011，，1： | 1 |
| 10 | Notritional issues in irritable bowel syndrome 显示文摘 | Dunlop Simon P Spiller Robin C | 2001 | Current Opinion in Clinical Nutrition & Metabolic Care2001，4，6： | 1 |
| 11 | Serotonergic modulating drugs for functional gastrointestinal diseases显示文摘 | Robin Spiller | 2002 | J Clin Pharmacol2002，54，： | 1 |
| 12 | Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome显示文摘 | Simon P. Dunlop Nicholas S. Coleman Elaine Blackshaw Alan C. Perkins Gulzar Singh Charles A. Marsden Robin C. Spiller | 2005 | Clinical Gastroenterology and Hepatology2005，，4： | 1 |
| 13 | Prevalence of gastrointestinal syndrome six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome:postal survey of patients显示文摘 | Keith R Neal John Heloden Robin spiller | 1997 | BMJ1997，314，3： | 1 |
| 14 | Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells显示文摘AIM: To study the mechanisms by which Campylobacter jejuni (C. jejuni) causes inflammation and diarrhea. In particular, direct interactions with intestinal epithelial cells and effects on barrier function are poorly under- stood. METHODS: To model the initial pathogenic effects of C. jejuni on intestinal epithelium, polarized human colonic HCA-7 monolayers were grown on permeabilized filters and infected apically with clinical isolates of C. jejuni. Integrity of the monolayer was monitored by changes in monolayer resistance, release of lactate dehydrogenase, mannitol fluxes and electron microscopy. Invasion of HCA-7 cells was assessed by a modified gentamicin protection assay, translocation by counting colony forming units in the basal chamber, stimulation of mediator release by immunoassays and secretory responses in monolayers stimulated by bradykinin in an Ussing chamber. RESULTS: All strains translocated across monolayers but only a minority invaded HCA-7 cells. Strains that invaded HCA-7 cells destroyed monolayer resistance over 6 h, accompanied by increased release of lactate dehydrogenase, a four-fold increase in permeability to [3H] mannitol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not. CONCLUSION: These data demonstrate two distinct effects of C. jejuni on colonic epithelial cells and provide an informative model for further investigation of initial host cell responses to C. jejuni. | Johannes Beltinger Jo del Buono Maeve M Skelly John Thornley Robin C Spiller William A Stack Christopher J Hawkey | 2008 | World Journal of Gastroenterology2008，14，48： | 1 |
| 15 | Serotonin and GI clinical disorders显示文摘 | Robin Spiller | 2008 | Neuropharmacology2008，，6： | 1 |
| 16 | Nutritional issues in irritable bowel syndrome显示文摘 | Simon P. Dunlop Robin C. Spiller | 2001 | Current Opinion in Clinical Nutrition and Metabolic Care2001，，6： | 1 |
| 17 | Clinical update: irritable bowel syndrome显示文摘 | Robin Spiller | 2007 | The Lancet2007，，9573： | 1 |
| 18 | Role of infection in irritable bowel syndrome显示文摘 | Robin C. Spiller | 2007 | Journal of Gastroenterology2007，，17： | 1 |
| 19 | Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution显示文摘Magnetic resonance imaging(MRI) is a well established technique that has revolutionized diagnostic radiology. Until recently, the impact that MRI has had in the assessment of gastrointestinal motor function and bowel fluid distribution in health and in disease has been more limited, despite the novel insights that MRI can provide along the entire gastrointestinal tract. MRI biomarkers include intestinal motility indices, small bowel water content and whole gut transit time. The present review discusses new developments and applications of MRI in the upper gastrointestinal tract, the small bowel and the colon reported in the literature in the last 5 years. | Asseel Khalaf Caroline L Hoad Robin C Spiller Penny A Gowland Gordon W Moran Luca Marciani | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 0 |
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