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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Current status of imaging in nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most common diffuse liver disease, with a worldwide prevalence of 20% to 46%. NAFLD can be subdivided into simple steatosis and nonalcoholic steatohepatitis. Most cases of simple steatosis are non-progressive, whereas nonalcoholic steatohepatitis may result in chronic liver injury and progressive fibrosis in a significant minority. Effective risk stratification and management of NAFLD requires evaluation of hepatic parenchymal fat, fibrosis, and inflammation. Liver biopsy remains the current gold standard; however, non-invasive imaging methods are rapidly evolving and may replace biopsy in some circumstances. These methods include well-established techniques, such as conventional ultrasonography, computed tomography, and magnetic resonance imaging and newer imaging technologies, such as ultrasound elastography, quantitative ultrasound techniques, magnetic resonance elastography, and magnetic resonancebased fat quantitation techniques. The aim of this article is to review the current status of imaging methods for NAFLD risk stratification and management, including their diagnostic accuracy, limitations, and practical applicability. | Qian Li Manish Dhyani Joseph R Grajo Claude Sirlin Anthony E Samir | 2018 | World Journal of Hepatology2018，10，8： | 6 |
| 3 | The fusarium wilt resistance locus Fom-2 of melon contains a single resistance gene with complex features显示文摘 | TAREK J JOSEPH J K SHELLY J N CLAUDE E T RALPH A D | 2004 | The Plant Journal2004，39，： | 1 |
| 4 | An entropy based classification scheme for land applications of polarimetrie SAR 显示文摘 | Claude S R Pottier E | 1997 | IEEE Transactions on Geoseience and Remote Sensing1997，35，1： | 1 |
| 5 | Electrical energy storage in ferroelectric polymer nanocomposites containing surface-functionalized BaTiO3 nanoparticles显示文摘 | Li J J Claude J Norena-Franco L E | | 0，，20： | 1 |
| 6 | Communication in the presence of noise显示文摘 | SHANNON CLAUDE E | 1949 | Proc IRE1949，37，： | 1 |
| 7 | Some recent development in mechanical activation and mechanosynthesis显示文摘 | Bernard F Claude J | 1999 | J Mater Chem1999，9，： | 1 |
| 8 | Programming a computer for playing chess显示文摘 | Shannon Claude E | 1950 | Philosophical Magazine1950，41，： | 1 |
| 9 | Multiresidue Analysis of 74 Pesticides in Fruits and Vegetables by Liquid Chromatography-Electrospray-Tandem Mass Spectrometry显示文摘 | DIDIER O PATRICK E CLAUDE C | 2004 | Analytica Chimica Acta2004，520，： | 1 |
| 10 | Nerve growth factor is a mitogen for cultured chromaffin cells显示文摘 | Lillien L E Claude P | 1985 | Nature1985，317，6038： | 1 |
| 11 | Effects of zeolite,formalin,bacterial augmentation,and aeration on total ammonia nitrogen concentrations显示文摘 | Claude E Sommai Boyd | 1993 | Aquaculture1993，11，6： | 1 |
| 12 | Integrin-linked kinase regulates the nuclear entry of the c-jun coactivatorα-NAC and its coactivation potency显示文摘 | Isabelle Q Claude G Gregory E H | 2004 | J Biol Chem2004，279，43： | 1 |
| 13 | Effects of zeohte,formalin,bacterial augmentation,and aeration on total ammonia nitrogen eoncentrations显示文摘 | Claude E Sommai Boyd | 1993 | Aquaculture1993，11，6： | 1 |
| 14 | Chilling injury induces lipid phase changes in membranes of tomato fruit 显示文摘 | Mohamed Sharom Claude Willemot John E Thompson | 1994 | Plant Physiol1994，，105： | 1 |
| 15 | Mechanical thrombectomy in patients with deep venous thrombosis显示文摘 | Maxence Delomez Jean-Paul Beregi M.D. Serge Willoteaux Jean-Jacques Bauchart Bertrand Janne d’Othée Philippe Asseman Nessim Perez Claude Théry | 2001 | Cardiovascular and Interventional Radiology2001，，1： | 1 |
| 16 | Programming a computer for playing chess显示文摘 | Claude E | 1950 | Philosophical Magazine1950，41，： | 1 |
| 17 | Response of soil microbial communities to compost amendments显示文摘 | Ana P P Ve'ronique E H Claude A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 18 | Lipoxygenase and hydroperoxide lyase activities in ripening tomato fruit显示文摘 | John C M Riley Claude Willemot John E Thompson | 1996 | Postharvest Biology and Technology1996，，7： | 1 |
| 19 | P-glycoprotein expression and function in patients withtemporal lobe epilepsy : a case-control study 显示文摘 | Maria Feldmann Marie Claude Asselin Joan Liu e?al | 2013 | LancetNeurol2013，12，8： | 1 |
| 20 | Relationship between organic carbon concentration and potential pond bottom soil respiration显示文摘 | Jiang Xinglong Claude E Boyd | 2006 | Aquacultural Engineering2006，35，2： | 1 |
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