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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 3 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 4 | Influence of age in estimating maximal oxygen uptake显示文摘ObjectiveTo 在最大的氧举起的估计( EE )的错误上估计年龄的影响( VO 2最大)用性别和在自从估计,测试的周期测力计锻练特定方程的人口, VO 2最大与实质的 EE 被联系,经常超过20%, 18~91 年,可能,由于机械 efficiency.Methods1850 的内在的可变性,成年人(68%人)经历了最大的周期测力计测试的心肺的锻练。心和肺的健康(CRF ) 相对性别和年龄被估计[更年轻(18 ~ 35 年) ,中年(36 ~ 60 年) 并且更旧(>60 年)] 。VO 2 最大[mL·(kg· min )−1] 被对煤气的交换的评价直接测量并且估计了使用性别和人口特定方程。VO 2 最大和相关 EE 在三年龄特定、性特定的 groups.ResultsDirectly 测量的 VO 2 男人和女人的最大是 29.5 ±10.5 mL·(kg· min )−1 和 24.2 ±9.0 mL·(kg· min )−1(P <0.01 ) 。EE [mL·(kg· min ) 为男人和女人的 −1] 和百分比错误(% E ) 有类似的价值, 0.5 ±3.2 和 0.4 ±2.9 mL·(kg· min )−1, 和 − 0.8 ±13.1% 并且 − 1.7 ±15.4%(P >0.05 ) 分别地。分别地,为每个年龄组的 EE 和 % E 为男人:更年轻的 = 1.9 ±4.1 mL·(kg· min )−1 和 3.8 ±10.5% ,中年的 = 0.6 ±3.1 mL·(kg· min )−1 和 0.4 ±10.3% ,更旧的 =− 0.2 ±2.7 mL·(kg· min )−1 和 − 4.2 ±16.6%(P <0.01 ) ;并且为女人:更年轻的 = 1.2 ±3.1 mL·(kg· min )−1 和 2.7 ±10.0% ,中年的 = 0.7 ±2.8 mL·(kg· min )−1 和 0.5 ±11.1% ,更旧的 =-0.8 ±2.3 mL·(kg· min )−1 和 − 9.5 ±22.4%(P <0.01 ).ConclusionVO 2 最大在更年轻的年龄组被低估并且在老年组被过高估计。年龄显著地影响 VO 2 在男人和女人的最大并且当 CRF 用人口被估计时,应该被认为特定方程,而非直接测量了。 | Christina G de Souza Silva Barry A Franklin Daniel E Forman Claudio Gil S Araujo | 2016 | Journal of Geriatric Cardiology2016，13，2： | 2 |
| 5 | Control of lymphocyte development by nuclear factor-kappaB显示文摘 | Siebenlist U Brown K Claudio E | 2005 | Nat Eev Immunol2005，5，： | 1 |
| 6 | Global attractors for a semilinear hyperbolic equation in viscoelasticity显示文摘 | Claudio G Munoz J E Pata V | 2001 | J Math Anal Appl2001，260，1： | 1 |
| 7 | Experience with SAND-TCL:A scripting tool for spatial databases显示文摘 | Claudio E Hanan S | 2002 | Journal of Visual Languages & Computing2002，13，2： | 1 |
| 8 | Control of lymphocyte development by nuclear factor-kappa B显示文摘 | Siebenlist U Brown K Claudio E | 2005 | Nat Rev Immunol2005，5，6： | 1 |
| 9 | An application of a multi-objective tabu search algorithm to a bicriteria flowshop problem 显示文摘 | Armentano V A Claudio J E | 2004 | Journal of Heuristics2004，10，5： | 1 |
| 10 | BAFF-induced NEMO-independent proessing of NF- κ B2 in maturing B cells 显示文摘 | Claudio E Brown K Park S | 2002 | Nat Immunol2002，3，： | 1 |
| 11 | Validation of hot ring rolling industrial process 3D simulation显示文摘 | GIORLEO L CLAUDIO G CERETTI E | 2013 | International Journal of Material Forming2013，6，1： | 1 |
| 12 | Adenoviral gene therapy inhigh - grade malignant glioma 显示文摘 | Pedersini R Vattemi E Claudio PP | 2010 | Drug News Perspect2010，23，6： | 1 |
| 13 | The adaptor proteinCIKS/ACT1 is necessary for collagen-induced arthritis, and itcontributes to the production of collagen-specific antibody 显示文摘 | Pisitkun P Claudio E Ren N | 2010 | Arthritis Rheum2010，62，11： | 1 |
| 14 | A molecular compendium of genes expressed in multiple myeloma 显示文摘 | Claudio JO Masih-Khan E Tang H | 2002 | Blood2002，100，： | 1 |
| 15 | The roles of the classical and alternative nuclear factor kappa B pathways: potential implications for autoimmunity and rheuma told arthritis 显示文摘 | Brown K D Claudio E Sjebenlist U | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 16 | Adenoviral gene therapy in head and neckcancer 显示文摘 | Vattemi E Claudio PP | 2006 | Drug News Perspect2006，19，6： | 1 |
| 17 | Fast adaptive digital equalization by recurrent neural networks显示文摘 | PARISI R DI CLAUDIO E D ORLANDI G | 2007 | IEEE Transactions on Signal Processing2007，45，7： | 1 |
| 18 | Control of lymphocyte develop-ment by nuclear factor~kappaB显示文摘 | Siebenlist U Brown K Claudio E | 2005 | Nat Rev Immunol2005，5，6： | 1 |
| 19 | Control of lymphocyte development by nuclear factor-kappaB 显示文摘 | Siebenlist U Brown K Claudio E | 2005 | Nat Rev lmmunol2005，5，6： | 1 |
| 20 | Design-driven laboratories:organization and strategy of laboratories specialized in the development of radical design-driven innovations显示文摘 | Claudio D E Verganti R | 2009 | R&D Management2009，1，39： | 1 |
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