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| 1 | Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights显示文摘AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above criteria.RESULTS Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with an F. nucleatum protein,fibroblast activation protein 2(FAP2). The clinical significance of detection or enrichment of Fusobacterium in colorectal neoplasia is ambiguous,but data suggest a procarcinogenic effect of F. nucleatum,likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. This is hypothesized to be mediated by certain F. nucleatum strains carrying invasive properties and virulence factors such as Fad A and FAP.CONCLUSION Evidence suggests a potential active role of Fusobacterium,specifically F. nucleatum,in CRC. Future prospective and experimental human studies would fill an important gap in this literature. | Hisham Hussan Steven K Clinton Kristen Roberts Michael T Bailey | 2017 | World Journal of Gastroenterology2017，23，48： | 9 |
| 2 | Lycopene: chemistry, biology and implication for human health and diseasc显示文摘 | Clinton S K | 1998 | Nutr Rev1998，56，2： | 1 |
| 3 | Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort显示文摘 | MICHAUD D S SPIEGELMAN D CLINTON S K | 1999 | J Natl Cancer I1999，91，： | 1 |
| 4 | Comparison of a warm gutta-percha obturation technique and lateral condensation 显示文摘 | CLINTON K VAN HIMEL T | 2001 | J Endod2001，27，11： | 1 |
| 5 | The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage显示文摘 | Clinton S K Schwartz S J | 2003 | Journal of Nutrition2003，133，3： | 1 |
| 6 | Decomposition and nutrient release from radiata pine ( Pinus radiata ) coarse woody debris显示文摘 | Girisha K Ganjegunte Leo M Condron Peter W Clinton Murray R Davis Nathalie Mahieu | 2003 | Forest Ecology and Management2003，，2： | 1 |
| 7 | Lycopene: Chemistry, biology, and implica- tions for human health and disease 显示文摘 | Steven K Clinton M D | 1998 | Nutrition Reviews1998，56，2： | 1 |
| 8 | Comparison of a warm gutra-percha obtura- tion technique and lateral condensation 显示文摘 | Clinton K van Himel T | 2001 | J Endod2001，27，11： | 1 |
| 9 | Comparison of a warm gutta-percha obturation technique and lateral condensation 显示文摘 | Clinton K Himel VT | 2001 | J Endod2001，27，11： | 1 |
| 10 | Associated factors of post-stroke depression among Hong Kong Chinese: a longitudinal study显示文摘 | Sit J W Wong T K Clinton M | 2007 | Psychol Health Med2007，12，2： | 1 |
| 11 | Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate 显示文摘 | Clinton S K Emenhiser C | 1996 | Cancer Epidemiol Biomarkers Prev1996，5，10： | 1 |
| 12 | A comparison of satiety, glycemic index, and insulinemic index of wheat-derived soft pretzels with or without soy 显示文摘 | Simmons A L Miller C K Clinton S K | 2011 | Food N- Function2011，2，11： | 1 |
| 13 | Lycopene: chemistry, biology, and impli- cations for human health and disease显示文摘 | Clinton S K | 1998 | Nutrition re- views1998，56，2： | 1 |
| 14 | Associated factors of post-stroke depression among Hong Kong Chinese:A longitudinal study显示文摘 | Sit J W Wong T K Clinton M | 2007 | Psychol Health Med J2007，12，2： | 1 |
| 15 | Comparison of a warm gutta -perche obturation technique and lateral condensation 显示文摘 | Clinton K Van Himal T | 2001 | J Endod2001，27，1： | 1 |
| 16 | Lycopene:chemistry,biology,and implications for human health and disease显示文摘 | Clinton S K | | 0，，02： | 1 |
| 17 | Stroke care in the home: the impact of social support on the general health of family caregivers显示文摘 | SIT J W WONG T K CLINTON M | 2004 | J Clin Nurs2004，13，7： | 1 |
| 18 | Interleukin - 1 gene expression in rabbit vascular tissue in vivo显示文摘 | CLINTON S K FLEET J C LOPPNOW H | 1991 | Am J Pathol1991，138，： | 1 |
| 19 | Lycopene : chemistry, biology, and implications for human health and disease显示文摘 | Clinton S K | 1998 | Nutr Rev1998，56，21： | 1 |
| 20 | Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase显示文摘 | Wang S De Groff V L Clinton S K | 2003 | TheJournal of Nutrition2003，133，7： | 1 |
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