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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 3 | Review:Ammonia emissions from dairy farms and beef feedlots显示文摘 | Hristov A N Hanigan M Cole A | 2011 | Canadian Journal of Animal Science2011，，91： | 1 |
| 4 | Carbon dioxide concentration and atmospheric flux in the Hudson River 显示文摘 | Raymond P A Caraco N F Cole J J | 1997 | Estuaries1997，20，2： | 1 |
| 5 | The ING gene family in the regulation of cell growth and tumorigenesis 显示文摘 | COLES A H JONES S N | 2009 | J Cell Physiol2009，218，1： | 1 |
| 6 | Direct brazing of ceramics, graphite and refractory metals显示文摘 | CANONICO D A COLE N C SLAUGHTER G M | 1977 | Welding Journal1977，，8： | 1 |
| 7 | Time-dependent complexation of cysteine-capped gold nanoparticles with octadecylamine Langmuir monolayers at the air-water interface显示文摘 | Mayya K M Cole A Jain N | 2003 | Langmuir2003，19，： | 1 |
| 8 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 9 | Spatial patterns of recreation impact on experimental camp sites显示文摘 | Cole D N Monz C A | 2004 | Environmental Management2004，70，1： | 1 |
| 10 | Influence of a propionate load in fed or unfed Iambs on blood metabolites and hormone patterns显示文摘 | COLE N A HALLFORD D M | 1994 | Anita Sci1994，72，： | 1 |
| 11 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 12 | Nutrient concentrations and proportions in particle size fractions of corn steam flaked to different bulk densities显示文摘 | Hales K E Cole N A Galyean M L | 2010 | Professional Animal Scientist2010，26，5： | 1 |
| 13 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing显示文摘 | Caraco N F Cole J J Raymond P A | 1997 | Ecology1997，78，2： | 1 |
| 14 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 15 | Carbon dioxide concentration and atmospheric flux in the Hudson River显示文摘 | RAYMOND P A CARACO N F COLE J J | 1997 | Estuaries1997，20，2： | 1 |
| 16 | Filtration of Hudson River water by the zebra mussel (Dreissena polymorpha)显示文摘 | Roditi H A Caraco N F Cole J J | 1996 | Estuaries and Coasts1996，19，4： | 1 |
| 17 | Influence of roughage level and corn processing method on the site and extent of digestion by beef steers显示文摘 | Cole N A Johnson R R Owens F N | 1976 | J Anim Sci1976，43，： | 1 |
| 18 | Temperature and the expression of seven muscle-specific protein genes during embryogenesis in the Atlantic cod Gadusmorhua L 显示文摘 | Hall T E Cole N J Johnston I A | 2003 | The Journal of Experimental Biology2003，206，18： | 1 |
| 19 | Soil textural control on decomposition and soil organic matter dynamies显示文摘 | Scott N A Cole C V Elliott E T | 1996 | Soil Science Society of America Journal1996，60，4： | 1 |
| 20 | Carbon dioxide concentration and atmospheric flux in the Hudson river 显示文摘 | Raymond P A Caraco N F Cole J J | 1997 | Estuaries1997，20，： | 1 |
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