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| 1 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 2 | Auction design in day-ahead electricity market (Republished)显示文摘 | Contreras J Candiles O Ignacio J | 2001 | IEEE Transactions on Power System2001，16，3： | 2 |
| 3 | The influence of the adsorption of amphiphiles and resins in controlling asphaltene flocculation显示文摘 | LEON O CONTRERAS E ROGEL E | 2001 | Energy & Fuels2001，15，5： | 1 |
| 4 | Adsorption of native resins on asphaltene particles:A correlation between adsorption and activity显示文摘 | LEON O CONTRERAS E ROGEL E | 2002 | Langmuir2002，18，13： | 1 |
| 5 | Stress urinary incontinence in the gynecological practice显示文摘 | Contreras Ortiz O | 2004 | Int J Gynaecol Obstet2004，86，1： | 1 |
| 6 | Amphiphile adsorption on asphaltene particles:Adsorption isotherms and asphaltene stabilization显示文摘 | LEON O CONTRERAS E ROGEL E | 2001 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2001，189，13： | 1 |
| 7 | A cobweb bidding model for competitive electricity markets显示文摘 | Contreras J Candiles O Ignacio de la Fuente J | 2002 | IEEE Transaction on Power Systems2002，17，1： | 1 |
| 8 | Amphiphile adsorption on asphaltene particles: Adsorption isotherms and asphaltene stabilization显示文摘 | LEON O CONTRERAS E ROGEL E | 2001 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2001，189，13： | 1 |
| 9 | Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-κB dependent mechanism显示文摘 | O′Toole D Hassett P Contreras M | 2009 | Thorax2009，64，： | 1 |
| 10 | Treatment options for severe lupus nephritis 显示文摘 | LENZ O CONTRERAS G | 2004 | Arch Immunol Ther Exp (Warsz)2004，52，5： | 1 |
| 11 | Adrenoleukodystrophy:impaired oxidation of fatty acids due to peroxisomal lignoceroyl-CoA ligase deficiency显示文摘 | Lazo O Contreras M Bhushan A | 1989 | Arch Biochem Biophys1989，270，： | 1 |
| 12 | 1995, Mexico city seismic alert system显示文摘 | Espinosa-Aranda J M Jim6nez A Contreras O Ibarrola G Ortega R | 1995 | Seis- tool Res Lett1995，66，6： | 1 |
| 13 | Structural, mor- phological and interracial characterization of A1-Mg/TiC com- posites显示文摘 | Contreras A Angdes-Chdvez C Flores O | 2006 | Materials Characterization2006，，58： | 1 |
| 14 | Role of electrohydraulic extracorporeal shockwave lithotripsy(Dornier HM 4)in the treatment of caliceal diverticulum lithiasis显示文摘 | Torrecilla O C Marco P L Contreras G J | 1998 | Actas Urol Esp1998，22，9： | 1 |
| 15 | Immune sys- tem modulates the function of adult neural stem cells显示文摘 | Gonzalez Perez O Jauregui Huerta F Galvez Contreras AY | 2010 | Curr Immunol Rev2010，6，3： | 1 |
| 16 | Microstructural evolution during large strain hot rolling of an AM60 Mg alloy显示文摘 | PEREZ-PRADO M T DEL VALLE J A CONTRERAS J M RUANO O A | 2004 | Scripta Materialia2004，50，5： | 1 |
| 17 | Auction design in day-ahead electricity markets (republished)显示文摘 | Contreras J Candiles O De la Fuente J | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 18 | Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts显示文摘 | TRAUB R D CONTRERAS D CUNNINGHAM M O | 2010 | Journal of Neurophysiology2010，93，4： | 1 |
| 19 | Foliage area and crown nitrogen turnover in temperate rain forest juvenile trees of differing shade tolerance显示文摘 | Lusk C H Contreras O | 1999 | Journal of Ecology1999，87，： | 1 |
| 20 | Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity显示文摘 | Escobedo N Contreras O Munoz R | 2013 | Development2013，140，14： | 1 |
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