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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Spectral beam combining of Yb-doped fiber lasers in an external cavity 显示文摘 | Cook C C Fan T Y Fejermm | 1999 | OSA Trends in Optics and Photonics1999，26，： | 1 |
| 3 | Cyber bullying behaviors a-mong middle and high school students显示文摘 | MISHNA F COOK C GADALLA T | 2010 | Am J Orthopsychiatry2010，80，3： | 1 |
| 4 | The gamblers fallacy in lottery play 显示文摘 | CLOTFELTER C T COOK P J | 1993 | Manag Sci1993，39，12： | 1 |
| 5 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 6 | Minerals of the system Bi-Te-Se-S related to the tetradymite archetype: Review of classification and compositional variation显示文摘 | COOK N J CIOBANU C L WAGNER T | 2007 | The Canadian Mineralogist2007，45，4： | 1 |
| 7 | Interelemental relationship in the soil and plant tissue and photosynthesis of field cultivated wheat growing in naturally enriched copper soils 显示文摘 | Vardaka E Cook C M Lanaras T | 1997 | Journal of Plant Nutrition1997，20，1： | 1 |
| 8 | Expression of the cyclin dependent kinase inhibitor p27 in keratocanthoma显示文摘 | HU W COOK T OH C W | 2000 | J Am Acad Dermatol2000，42，： | 1 |
| 9 | The mechanisms of the formation and growth of water bubbles and associated dislocation loops in synthetic quartz显示文摘 | McLaren A C Cook R F Hyde S T | 1983 | Phys Chem Mineral1983，9，： | 1 |
| 10 | Defect in peroxisome prolifera- tor-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting 显示文摘 | Hashimoto T Cook WS Qi C | 2000 | J Biol Chem2000，275，28： | 1 |
| 11 | Removal of oil,grease,and suspended solids from produced water with ceramic crossflow microfiltration显示文摘 | Chen A S C Flynn J T Cook R G | 1991 | SPE Production Engineering1991，6，2： | 1 |
| 12 | Interelemental relationship in the soil and plant tissue and photosynthesis of field cultivated wheat growing in naturally enriched copper soils显示文摘 | Vardake E Cook C M Lanaras T | 1997 | J Plant Nutr1997，20，45： | 1 |
| 13 | Effects of chronic inhibition of GABA synthesis on attention and impulse control显示文摘 | PAINE T A COOKE E K LOWES D C | 2015 | Pharmacol Biochem Behav2015，135，： | 1 |
| 14 | Reduced coronary events in simvastatintreated payients with coronary heart disease and diabetes or impaired fasting glucose levels:subgroup analyses in the Scandinavian Simvastatin Survival Study显示文摘 | Haffner S M Alexander C M Cook T J | 1999 | Arch Intern Med1999，159，22： | 1 |
| 15 | The Oxford classification of IgA nephropathy : rationale, clinicopathologieal correlations, and classification显示文摘 | Cattran D C Coppo R Cook H T | 2009 | Kidney Int2009，76，5： | 1 |
| 16 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 17 | Cyber bullying behaviors a-mong middle and high school students显示文摘 | MISHNA F COOK C GADALLA T | 2010 | Am J Orthopsych2010，80，3： | 1 |
| 18 | Defect in peroxisome prol- iferator-activated receptor-inducible fatty acid oxidation deter- mines the severity of hepatic steatosis in responseto fasting显示文摘 | Hashimoto T Cook W S Qi C | 2000 | J Biol Chem2000，275，28： | 1 |
| 19 | Positive interactions among alpine plants increase with stress显示文摘 | Callaway R M Brooker R W Choler P Kikvidze Z Lortie C J Michalet R Paolini L Pugnaire F I Newingham B Asche- houg E T Armas C Kikodze D Cook B J | 2002 | Nature2002，417，： | 1 |
| 20 | Comment on “A reservoir of nitrate beneath desert soils”显示文摘 | JACKSON R B BERTHRONG S T COOK C W | 2004 | Science2004，304，5667： | 1 |
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