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| 1 | 激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。 | Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 | 2015 | 矿物岩石地球化学通报2015，34，4： | 114 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 3 | 中国糖尿病:流行病学、基因易感性和个性化治疗的临床应用显示文摘近些年来,中国2型糖尿病患病率出现快速增长,这使得2型糖尿病已经成为了一个重要的公共卫生问题。和欧洲人相比,相中国2型糖尿病诊断患者年龄较小、且体重指数较低。为了今后预防和干预项目的实施,有必要对此现象进行深入研究。除环境因素外,基因对于2型糖尿病的发生和发展起到至关重要的作用。迄今为止已经被识别的2型糖尿病的易感基因位点达百余个。就个体而言,大多数2型糖尿病的基因变异效应量较小(每个危险等位基因增加10%~20%的2型糖尿病风险)。可以利用多个等位基因来计算遗传风险得分,进而预测2型糖尿病和识别高危人群。此外,预防2型糖尿病的并发症和死亡时应优先考虑个性化的药物治疗。本研究回顾了2型糖尿病基因病因学近期的流行病学研究趋势和进展情况,并对2型糖尿病个性化治疗进行了深入探讨。 | Hu C Jia W 姜莹莹(编译) | 2019 | 中华预防医学杂志2019，53，2： | 18 |
| 4 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 5 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 6 | DEFORMATION ENHANCED FERRITE TRANSFORMATION IN PLAIN LOW CARBON STEEL显示文摘The microstructure evolution during deformation enhanced transformation of under cooled austenite of a plain low carbon steel has been investigated by means of hot compression simulation experiment under various conditions of strain rate,deforma- tion temperature and strain. The effect of austenite grain size on the strain enhanced ferrite transformation has been studied. The ferrite dynamic recrystallization involved in successive hot deformation has been explored. | Z.Q. Sun, W Y. Yang, A.M. Hu and P. Yang (State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083, China) (School of Material Science and Engineering, University of Science and Technology Beijin | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，2： | 7 |
| 7 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 8 | 急性肾损伤与慢加急性肝衰竭患者的短期不良预后显著相关显示文摘【据Journal of Viral Hepatitis 2020年8月报道】题:慢加急性肝衰竭患者中急性肾损伤的患病率和短期预后:荟萃分析(作者Jiang W等)发生在慢加急性肝衰竭(ACLF)与肝硬化患者的急性肾损伤(AKI)临床特点不同,但目前关于ACLF人群AKI疾病特征的研究较少。这项荟萃分析的目的是评估AKI对ACLF结局的影响。 | 蒋维芸 荀运浩 JIANG W HU Y SUN Y | 2020 | 临床肝胆病杂志2020，36，9： | 4 |
| 9 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 10 | Alcoholic hepatitis: The pivotal role of Kupffer cells显示文摘Kupffer cells play a central role in the pathogenesis of alcoholic hepatitis(AH). It is believed that alcohol increases the gut permeability that results in raised levels of serum endotoxins containing lipopolysaccharides(LPS). LPS binds to LPS-binding proteins and presents it to a membrane glycoprotein called CD14, which then activates Kupffer cells via a receptor called tolllike receptor 4. This endotoxin mediated activation of Kupffer cells plays an important role in the inflammatory process resulting in alcoholic hepatitis. There is no effective treatment for AH, although notable progress has been made over the last decade in understanding the underlying mechanism of alcoholic hepatitis. We specifically review the current research on the role of Kupffer cells in the pathogenesis of AH and the treatment strategies. We suggest that the imbalance between the pro-inflammatory and the anti-inflammatory process as well as the increased production of reactive oxygen species eventually lead to hepatocyte injury, the final event of alcoholic hepatitis. | Duminda B Suraweera Ashley N Weeratunga Robert W Hu Stephen J Pandol Richard Hu | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 3 |
| 11 | Four multidetector-row helical CT: image quality and volume coverage speed显示文摘 | Hu H He H D Foley W D | 2000 | Radiology2000，215，1： | 2 |
| 12 | Analytical study on possible self-excited oscillation in S-shaped regions of pump-turbines显示文摘 | Zhou J X Karney B W Hu M Xu J C | 2011 | Proceedings of the Institution of Mechanical Engineers2011，，8： | 2 |
| 13 | HMM-Based On-line Handwriting Recognition 显示文摘 | Hu J Brown MK Turin W | 1996 | IEEE Transactions on Pattern Analysis and Machine Intelligence1996，18，10： | 2 |
| 14 | 深部地球条件下铁和氧元素的化学变化显示文摘氧与铁分别为地球上丰度最高的元素与占地球质量最大的元素,它们所形成的化合物遍布我们的星球,具有-2价的氧控制着地球的氧逸度,随着深度的增加氧逸度逐渐降低,与铁所形成的氧化物中铁的价态也逐渐降低,O/Fe逐渐增加,近些年来科学家们发现深部地球条件下铁的一系列氧化物,其中具有高压黄铁矿结构的铁超氧化物FeO2具有最高的O/Fe,并且它还能够携带一定量的H(表示为Py-FeO2H,, x=0-1)。 | 夏群科 Liu J Hu Q Y Bi W L Yang L X Xiao Y M Chow P Meng Y.Prakapenka V B Mao H K Mao W L | 2019 | 矿物岩石地球化学通报2019，38，3： | 2 |
| 15 | Natural Convective Boiling in Vertical Rectangular Narrow Channels 显示文摘 | Xia C Hu W Guo Z Y | 1996 | Experimental Thermal and Fluid Science1996，12，： | 2 |
| 16 | Cervical Intervertebral Disc Degeneration Induced by Unbalanced Dynamic and Static Forces: A Novel In Vivo Rat Model显示文摘 | Yong-Jun Wang Qi Shi W W. Lu K C. M. Cheung Michael Darowish Tian-Fang Li Yu-Feng Dong Chong-Jian Zhou Quan Zhou Zhi-jun Hu Mei Liu Qin Bian Chen-Guang Li K D. K. Luk J C. Y. Leong | 2006 | Spine2006，，14： | 2 |
| 17 | 抗生素使用的时间长短和使用时的生命阶段与全因/特定原因死亡风险的关系:一项前瞻性队列研究显示文摘过度使用抗生素一直是一个重要的临床问题,抗生素使用与肠道微生物菌群的改变有关,肠道菌群的改变与各种慢性疾病如心血管病和癌症的风险有关。此外,抗生素使用的时间可能是过早死亡的一个危险因素。研究者调查了成年期间使用抗生素的生命阶段和使用持续时间与全因和特定原因死亡风险的关系。该项前瞻性队列研究包括来自护士健康研究、均未患有心血管病或癌症的37516名年龄≥60岁的女性,收集其中年(40~59岁)和老年(≥60岁)使用抗生素的时间(无,<15d,15d至<2个月,或≥2个月)。研究者根据抗生素的使用时间估计10年内全因死亡率和心血管病或癌症的死亡风险比(HR)。在355918人年的随访中,研究者记录了所有原因导致的4536例死亡(包括728例心血管病死亡和1206例癌症死亡) | 刘青(译) 叶鹏(摘 审校) Heianza Y Ma W Li X Cao Y Chan A Rimm EB Hu FB Rexrode K Manson JE Qi L | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 18 | Electrochemical deposited amorphous FeNi hydroxide electrode for oxygen evolution reaction显示文摘The electrodeposition approach is significant in electrode fabrication for practical application.Herein,the electrodeposited amorphous NiFe hydroxide species for oxygen evolution reaction (OER) in water splitting reaction is demonstrated by revealing the synergistic effect influenced by the support electrode of Fe and Ni foil and the contents of Fe and Ni in the electrolyte.All the electrodeposited samples have an amorphous structure and similar profiles of binding energy and chemical states for Fe and Ni as characterized by the spectroscopic techniques.While the support effect and Fe/Ni synergistic effect are indeed observed for the varied catalytic performances observed for the different electrodes;the Ni foil supported catalyst exhibits much higher performance than that of the Fe foil supported catalyst,and the different redox potentials of Ni species in the different Fe/Ni electrode resulting from the Fe–Ni synergism are observed in the cyclic voltammetry curve analysis.The surface roughness and the electrochemical surface area are also influenced by the support effect and the Fe/Ni ratio in the plating electrolyte.The optimal electrode shows a very low overpotential of~200 mV to reach 10 mA cm^(-2),and very high catalytic stability by the consecutive cyclic voltammetry measurements and 20 h stability test.Though it has the largest electrochemical surface area,the highest catalytic efficiency for these active sites is also indicated by the specific activity and turnover frequency polarization curves.The current work shows the effective experience for the electrodeposited Fe/Ni based catalysts in large-scale fabrication,which can be more practical for hydrogen generation in the alkaline water electrolysis. | Zhengzhi Yin Runze He Yongcai Zhang Ligang Feng Xiang Wu Thomas Wågberg Guangzhi Hu | 2022 | Journal of Energy Chemistry2022，31，6： | 2 |
| 19 | Adjuvant intraportal venous chemotherapy for patients with hepatocellular carcinoma and portal vein tumor thrombi following hepatectomy plus portal thrombectolny 显示文摘 | Liang L J Hu W J Yin X Y | 2008 | World J Surg2008，32，4： | 1 |
| 20 | Does dying at home influence the good death of terminal cancer patients? 显示文摘 | Yao C A Hu W Y Lai Y F | 2007 | J Pain Symptom Manage2007，34，5： | 1 |
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