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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | Sensitivity analysis of a fixed-bed gas-solid TSA: the problem of design with uncertain models 显示文摘 | Ratto M Lodi G Costa P | 1996 | Separations Technology1996，6，4： | 1 |
| 5 | Acetylcholine as a mitogen:muscarinic receptor - mediated proliferation of rat astrocytes and human astrocytoma cells 显示文摘 | Costa P Peters J | 1996 | Eur Phamacol1996，297，： | 1 |
| 6 | Fatigue behaviour of AA6082 friction stir welds under variable loadings显示文摘 | COSTA J D FERREIRA J A M BORREGO L P | 2012 | In- ternational Journal of Fatigue2012，37，： | 1 |
| 7 | Molecularcloning and characterization of a vacuolar classⅢperoxidaseinvolved in the metabolism of anticancer alkaloids in Catha-ranthus roseus显示文摘 | COSTA M M HILLIOU F DUARTE P | 2008 | Plant Physiology2008，146，2： | 1 |
| 8 | New catalysts fordeep hydrotreatment of diesel fuel: Kinetics of 4,6-dimethyldibenzothiophenehydrodesulfurization over aluminasupportedmolybdenum carbide显示文摘 | Costa P Da Potvin C Manoli J M | 2002 | Journal of MolecularCatalysis A: Chemistry2002，184，12： | 1 |
| 9 | Can the integration\sof multiple biomarkers and sediment geochemistry aidsolving the complexity of sediment risk assessment?Acase study with a benthic fish显示文摘 | Costa P M Caeiro S Vale C | 2012 | Environmental Pollution2012，161，0： | 1 |
| 10 | Connectivity between estuaries and marine environment:Integrating metrics to assess estuarine nursery function显示文摘 | VASCONCELOS R P REIS-SANTOS P COSTA M J | 2011 | Ecological Indicators2011，11，5： | 1 |
| 11 | Mechanism of condensed phase action in fire retardant bismuth compound-chloroparaflin-poly- propylene mixtures: Part I -The role ofbismuth trichloride and oxy- chloride 显示文摘 | Costa L Camino G Cortemiglia M P L | 1986 | Polym Degrad Stab1986，14，： | 1 |
| 12 | New frontiers in cardiology:drug-eluting stents-part 1显示文摘 | SERRUYS P W COSTA M A | 2003 | Circulation2003，107，： | 1 |
| 13 | Magnetic properties of nanocrystalline Ni-Zn ferrites doped with samarium显示文摘 | Gama L Diniz A P Costa A C F M | 2006 | Physica B2006，384，12： | 1 |
| 14 | Start up analysis for automotive PEM fuel cell systems显示文摘 | Francesco M D Arato E Costa P | 2002 | Journal of Power Sources2002，108，： | 1 |
| 15 | Dioxygen activation at mononuclear nonheme iron active sites:Enzymes,models and intermediates显示文摘 | Costas M Mehn M P Jensen M P | 2004 | Chem Rev2004，104，： | 1 |
| 16 | Competitive adsorption of zinc,cadmium,copper and lead in three highly weathered Brazilian soils显示文摘 | Fontes M P F Matos A F Costa L M | 2000 | Commun Soil Sci Plant Anal2000，31，： | 1 |
| 17 | Water-deficit-responsive proteins in maritime pine显示文摘 | COSTA P BAHRMAN N FRIGERIO J M | 1998 | Plant Mol Biol1998，38，4： | 1 |
| 18 | Potassium-use efficiency in common bean genotypes 显示文摘 | FAGERIA N K BARBOSA COSTA M P | 2001 | Journal of Plant Nutrition2001，24，12： | 1 |
| 19 | Correlation between the surface properties and deNOx activity of ceria-zirconia catalysts显示文摘 | ADAMOWSKA M MULLER S COSTA P D KRZTON A BURG P | 2007 | Applied Catalysis B: Environmental2007，74，34： | 1 |
| 20 | Yield and composition of the essential oil of Ocimum selloi Benlh cultivated under colored netting显示文摘 | Costa L C B Pinto J E B P Castro E M | 2010 | Journal of Essential Oil Research2010，22，1： | 1 |
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