|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Complete sequence of bovine mitochondrial DNA:Conserved features of the mammalian mitochondrial genome显示文摘 | Anderson S de Bruijn M H L Coulson A R | 1982 | J Mol Biol1982，156，： | 1 |
| 3 | U-Pb zircon,geochemical and Sr-Nd-Hf isotopic constraints on the age and origin of Early Palaeozoic Ⅰ-type granite from the Tengchong-Baoshan Block,western Yunnan province,SW China显示文摘 | Liu S Hu R Z Gao S Feng C X Huang Z L Lai S C Yuan H L Liu X M Coulson I M Feng G Y Wang T and Qi Y Q | | 0，，： | 1 |
| 4 | Tenure Choice and Labour Market Outcomes显示文摘 | Coulson E N Fisher L M | 2002 | Housing Studies2002，17，1： | 1 |
| 5 | Zircon U-Pb geochronology and major, trace elemental and Sr-Nd-Pb isotopic geochemistry of mafic dykes in western Shandong province, east China: Constrains on their petrogenesis and geodynamic significance 显示文摘 | LIU S HU R Z GAO S FENG C X QI L ZHONG H XIAO T F QI Y Q WANG T COULSON L M | 2008 | Chemical Geology2008，255，3： | 1 |
| 6 | A Passive Sonar System Based on an Autonomous Underwater Vehicle显示文摘 | Glegg S A L Olivieri M P Coulson R K et al | 2001 | IEEE Journal of Oceanic Engineering2001，，4： | 1 |
| 7 | p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate显示文摘 | Coulson E J May L M Osborne S L | 2008 | J Neurosci2008，28，1： | 1 |
| 8 | Upstream stimulatory factor activates the vasopressin promoter via multiple motifs,including a non-canonical E-box显示文摘 | COULSON J M EDGSON J L MARSHALL-JONES Z V | 2003 | Biochem J2003，369，： | 1 |
| 9 | Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome 显示文摘 | Anderson S de Bruijn M H L Coulson A B | 1982 | J Mol Biol1982，156，： | 1 |
| 10 | A Splice Variant of the Neuronrestrictive Silencer Factor Repressor is Expressed in Smal Cell Lung Cancer:A Potential Role in Derepression of Neuroendocrine Genes and a Useful Clinical Marker显示文摘 | Coulson J M Edgson J L Woll P J Quinn J P | 2000 | Cancer Res2000，60，7： | 1 |
| 11 | Complete sequence of bovine mitochondrial DNA:Conserved features of the mammalian mitochondrial genome显示文摘 | Anderson S de Bruijn M H L Coulson A R | 1982 | Journal of Molecular Biology1982，156，： | 1 |
| 12 | A pas- sive sonar system based on an autonomous underwater vehi- cle 显示文摘 | GLEGG S A L lIVIERI M P COULSON R K | 2001 | IEEE Journal of Oceanic Engineering2001，，： | 1 |
| 13 | A passive sonar system based on an autonomous underwater vehi- cle显示文摘 | Glegg S A L Olivieri M P Coulson R K | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 14 | Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome显示文摘 | Anderson S de Bruijn M H L Coulson A B | 1982 | J Mol Biol1982，156，： | 1 |
| 15 | Inhibitor of apoptosis proteins and their relatives: lAPs and other BIRPs显示文摘 | VERhHAGEN A M COULSON E J VAUX D L | 2001 | Genome Biol2001，2，7： | 1 |
| 16 | A passive sonar system based on an autonomous underwater vehicle 显示文摘 | Glegg S A L Olivieri M P Coulson R K | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 17 | Cognitive flexibility, constructivism and hypertext: Ad- vanced knowledge acquisition in ill -structured domains 显示文摘 | Spiro R J Feltovich P J Jacobson M Coulson R L | 1989 | Educational Technology1989，31，： | 1 |
| 18 | Mechanical properties of rat middle cerebral arteries with and without myogenic tone显示文摘 | Coulson R J Cipolla M J Vitullo L | 2004 | J Biomech Eng2004，126，1： | 1 |
| 19 | Complete sequence of bovine mitochondrial DNA, conserved feature of the mammalian genome 显示文摘 | Anderson S de Brujin M H L Coulson A R | 1982 | Journal of Molecular Evolution1982，156，4： | 1 |
| 20 | Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome显示文摘 | Anderson S De Bruijn M H L Coulson A B | 1982 | J Mol Biol1982，156，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员