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| 1 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 2 | Microscopic colitis: A retrospective study of clinical presentation in 53 patients显示文摘AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and diarrhea.METHODS: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively analyzed.RESULTS: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation subgroup.CONCLUSION: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups. | Zsolt Barta Gabriella Mekkel István Csíp(o|') László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher | 2005 | World Journal of Gastroenterology2005，11，9： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Cervical spine fusion in rheumatoid arthritis显示文摘 | Ranawat CS O'Leary P Pellicci P | 1979 | J Bone Joint Surg Am1979，61，7： | 1 |
| 5 | Long-term results of first salvage treatment in CLL patients treated initially with FCR(fludarabine,cyclophosphamide,rituximab)显示文摘 | Tam CS O'Brien S Plunkett W | 2014 | Blood2014，124，： | 1 |
| 6 | Outcomes of stent thrombosis and restenosis during extended follow-up of patients treated with bare-metal coronary stents显示文摘 | Doyle B Rihal CS O' Sullivan CJ | 2007 | Circulation2007，116，21： | 1 |
| 7 | High prevalence of peripheral arterial disease in persons with renal insufficiency 显示文摘 | O'Hare A Glidden DV Fox CS | 2004 | Circulation2004，，： | 1 |
| 8 | Maintenance of functional stem cells in isolated and cultured adult intestinal epithelium显示文摘 | Booth C O'Shea JA Potten CS | 1999 | Exp Cell Res1999，249，2： | 1 |
| 9 | Putting humpty dumpty together again:the importance of integrating cognitive and emotional interventions显示文摘 | Mateer CA Sira CS O'Connell ME | | 0，，01： | 1 |
| 10 | Chemokines in rheumatic diseases显示文摘 | Szekanecz Z Sz u cs G Sz a nt o S | 2006 | Curr drug targets2006，7，1： | 1 |
| 11 | Breast cancer stem cells and their role in resistance to endocrine therapy显示文摘 | O'Brien CS Farnie G Howell SJ | 2011 | Horm Cancer2011，2，2： | 1 |
| 12 | Cetu-ximab for the treatment of colorectal cancer 显示文摘 | Jonker DJ O' Callaghan CJ Karapetis CS | 2007 | N Engl JMed^2007，357，20： | 1 |
| 13 | Long-term results of the fludarabine, eyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia 显示文摘 | Tam CS O'Brien S Wierda W el al | 2008 | Blood2008，112，4： | 1 |
| 14 | High prevalence of peripheral arterial disease in persons with renal insufficiency:Results from the national health and nutrition examination survey 1999-2000 显示文摘 | O'Hare AM Glidden DV Fox CS | 2004 | Circulation2004，109，： | 1 |
| 15 | Neural stem cells from mouse forebrain are contained in a population distinct from the ' side population' 显示文摘 | Mouthon MA Fouchet P Mathieu C Sii-Felice K Etienne O Lages CS | 2005 | J Neurochem2005，99，3： | 1 |
| 16 | Dynamics of information access on the web显示文摘 | DEZS(O) Z ALMAAS E LUK(A)CS A | 2006 | Phys Rev E2006，73，06： | 1 |
| 17 | Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma 显示文摘 | Kargiotis O Chetty C Gondi CS | 2008 | Oncogene2008，27，35： | 1 |
| 18 | Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial显示文摘 | Yuan CS Foss JF O'Connor M | 1996 | Clin Pharmacol Ther1996，59，4： | 1 |
| 19 | Cetuximab for the treatment of colorectal cancer 显示文摘 | JONKER DJ O'CALLAGHAN CJ KARAPETIS CS | 2007 | Engl J2007，375，20： | 1 |
| 20 | Effects of angiotensin Ⅱ infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling显示文摘 | Mollnau H Wendt M Sz(o)cs K | | 0，，： | 1 |
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