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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Comparison of esophageal stenoses produced by endoscopic sclerotherapy versus variceal ligation 显示文摘 | de la Pena J Orive A Cuadrado A | 2006 | Gastroenterol Hepatol2006，29，9： | 1 |
| 3 | Study of spectral analytical data using fin- gerprints and scaledsimilarity measurements显示文摘 | M Urbano Cuadrado M D Luque de Castro M A Go mez-Nieto | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 4 | Role of microglial redox balance in modulation of neuroinflammation显示文摘 | Innamorato NG Lastres-Becker I Cuadrado A | | 0，，： | 1 |
| 5 | Sildeuafil restores cognitive function without affecting β - amyloid burden in a mouse model of Alzheimer's disease显示文摘 | CUADRADO - TEJEDOR M HERVIAS I RICOBARAZA A | 2011 | Br J Pharmacol2011，164，8： | 1 |
| 6 | Transcription factors NRF2 and NF-kappaB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation 显示文摘 | Cuadrado A Martin-Moldes Z Ye J | 2014 | J Biol Chem2014，289，15： | 1 |
| 7 | Mechanisms and functions of p38MAPK signalling显示文摘 | Cuadrado A Nebreda AR | 2010 | Biochem J2010，429，3： | 1 |
| 8 | MMP- 9- positive neutrophil infiltration is associated to blood - brain barrier breakdown and basal lamina type 1V collagen degradation during hemorrhagic transformation after human ischemic stroke 显示文摘 | ROSELL A CUADRADO E ORTEGA AZNAR A | 2008 | Stroke2008，39，4： | 1 |
| 9 | Mechanisms and functions of p38 MAPK signalling显示文摘 | CUADRADO A NEBREDA AR | 2010 | Biochem J2010，429，3： | 1 |
| 10 | Some Synthetic Applications of Vinylphosphane Oxides显示文摘 | Cuadrado P Gonzalez-Nogal A M Sarmentero M A | 2010 | Tetrahedron2010，66，50： | 1 |
| 11 | Transcription factors NRF2 and NF- KB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation显示文摘 | Cuadrado A Martin-Moldes Z Ye J | 2014 | J Biol Chem2014，289，15： | 1 |
| 12 | Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK 显示文摘 | Cuadrado A Garcia-Fernandez LF Gonzalez L | 2003 | J Biol Chem2003，278，： | 1 |
| 13 | Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome显示文摘 | Carlos Zamarrón Luis Valdés Cuadrado Rodolfo álvarez-Sala Francisco García Río | 2013 | <journal-title>Pulmonary Medicine2013，，： | 1 |
| 14 | Fas system activation in perihematomal areas after spontaneous intracerebral hemorrhage 显示文摘 | Delgado P Cuadrado E Rosell A | 2008 | Stroke2008，39，6： | 1 |
| 15 | B-type natriuretic peptide in the emergency diagnosis of critical heart disease in children显示文摘 | Maher KO Reed H Cuadrado A | 2008 | Pediatrics2008，121，6： | 1 |
| 16 | MMP-9- positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke显示文摘 | Rosell A Cuadrado E Ortega-Aznar A | 2008 | Stroke2008，39，4： | 1 |
| 17 | MMP-9-positiveneutrophilin filtration is associated to blood-brain barrier breakdown andbasallam inatype IV collagen degradati on during hemorrhagic transforma-tion after human ische mic stroke 显示文摘 | Rosell A Cuadrado E Ortega-Aznar A | 2008 | Stroke2008，39，4： | 1 |
| 18 | Kahalalide F,a new marine derived,induces oneosis in human prostate and breast cancer cells显示文摘 | Suarez Y Gonzalez L Cuadrado A | 2003 | Mol Cancer Ther2003，2，9： | 1 |
| 19 | Transvaginal liver resection (NOTES) combined wilh minilaparoscopy 显示文摘 | Noguera JF Dolz C Cuadrado A | 2008 | Rev Esp Enferm Dig2008，100，7： | 1 |
| 20 | Simultaneous cytomorphologic and muhiparameuic flow cytometric analysis on lymph node samples is faster than and as valid as histopathologic study to diagnose most non-Hodgkin lym- phomas显示文摘 | Colorado M Cuadrado MA Insunza A | 2010 | Am J Clin Pathol2010，133，1： | 1 |
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