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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Definition of the Portuguese frameworks with international relevance as an input for the European geological heritage characterisation显示文摘 | J. Brilha C. Andrade A. Azeredo F.J.A.S. Barriga M. Cachāo2 H. Couto P.P. Cunha J.A. Crispim P. Dantas L. V. Duarte M. C Freitas H.M. Granja M.H. Henriques P. Henriques L. Lopes J. Madeira J.M.X. Matos F. Noronha J. Pais J. Pifarra M.M. Ramalho J.M.R.S. Relvas A. Ribeiro A. Santos V.F.Santos P. Terrinha | 2005 | Episodes2005，28，3： | 5 |
| 3 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 4 | Widely used herpes simplex virus 1 ICP0 deletion mutant strain d11403 and its derivative viruses do not express glycoprotein C due to a secondary mutation in the gC gene显示文摘 | Cunha C W Taylor K E Pritchard S M | 2015 | Plos One2015，10，13： | 1 |
| 5 | Selection of models of lactation curves to use in milk production simulation systems显示文摘 | Cunha D N F V Pereira J C Campos O F | 2010 | Rev Bras Zootecn2010，39，4： | 1 |
| 6 | 3D reconstitution of porous media from image processing data using a mulfiscale percolation system 显示文摘 | DAIAN J F FERNANDES C P PHILIPPI P C BELLINI DA CUNHA NETO J A | 2004 | Journal of Petroleum Science and Engineering2004，42，1： | 1 |
| 7 | 查看详情显示文摘 | Wang X F da Cunha Lima I C Lei X L | | 0，，： | 1 |
| 8 | Sequential solid-state and submerged cultivation of Aspergillus niger on sugarcane bagasse for the production of cellulose显示文摘 | Cunha F M Esperanca M N Zangirolami T C | 2012 | Bioresource Technology2012，112，： | 1 |
| 9 | Hydrodynamics and water quality models applied to Sepetiba Bay 显示文摘 | CUNHA C D D ROSMAN P C C FENREIRA A P | 2006 | Continental Shelf Research2006，26，16： | 1 |
| 10 | Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats显示文摘 | Chioca LR Raupp IM Da Cunha C | 2008 | Eur J Pharmacol2008，579，13： | 1 |
| 11 | Preoperative assessment of deep myometrial and cervical invasion in endometrial carcinoma:comparison ofmagnetic resonance imaging and histopathologic evaluation显示文摘 | Vasconcelos C Felix A Cunha TM | 2007 | J Obstet Gynaecol2007，27，8： | 1 |
| 12 | Altering the time of the second gonadotropin-releasing hormone injection and artifi- cial insemination (AI)during Ovsyneh affects pregnancies per AI in lactating dairy cows显示文摘 | Brusveen D J Cunha A P Silva C D | 2008 | J Dairy Sci2008，91，3： | 1 |
| 13 | Contraction stress and physical properties development of a resin- based composite irradiated using modulated curing meth- ods at two C-factor levels 显示文摘 | Cunha L G Alonso R C Pfeifer C S | 2008 | Dent Mater2008，24，3： | 1 |
| 14 | Assessment of 4- (5-)methylimidazole in soft drinks and dark beer显示文摘 | S C Cunha A I Barrado M A Faria et a/ | 2011 | Journal of Food Composition and Analysis2011，24，： | 1 |
| 15 | A second liver resection due to recurrent colorectal liver metastases显示文摘 | Cunha AS Laurent C Rault A | 2007 | Arch Surg2007，142，12： | 1 |
| 16 | Phosdhatidvlserine reverses reserpine: induced amnesia显示文摘 | ALVES C S ANDREATINI R CUNHA C D | 2000 | European Journal of Pharmacology2000，404，12： | 1 |
| 17 | Catheter ablation of severe neurally meditated reflex (neuroeardiogenic or vasovagal) syncope : cardioneuroablation long-term results 显示文摘 | Pachon J C Pachon E I Cunha Pachon M Z | 2011 | Europace2011，13，9： | 1 |
| 18 | Acute respiratory distress syndrome in a child with human parvovirus B19 infection显示文摘 | Ferraz C Cunha F Mota TC | 2005 | Pediatr Infect Dis J2005，24，11： | 1 |
| 19 | Fish off flavor analysis by hcadspace and off line purge-and-trap followed by HRGC MS 显示文摘 | Santos G V Da Cunha Veloso M C De Paula Pereira PA | 2001 | American Lab-oratory2001，33，24： | 1 |
| 20 | Optimisation of extraction procedures for analysis of benzoic and sorbic acids in foodstuffs显示文摘 | Mota F J M Cunha S C Beatriz M | 2003 | Food Chemistry2003，82，： | 1 |
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