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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Dectin- 1 isoforms contribute to distinct Th 1/Th 17 cell activation in mucosal candidiasis显示文摘β 的识别;由 dectin-1 的 -glucans 被显示了调停房间激活, cytokine 生产和许多抗真菌的回答。这里,我们报导在到 Candida albicans 的 mucosal 免疫的 dectin-1 的功能的活动被主人的基因背景影响。Dectin-1 在 C57BL/6,然而并非 BALB/c 老鼠为胃肠、阴道的 candidiasis 的合适的控制被要求;事实上,后者当 dectin-1 不在时显示出增加的抵抗。到感染的 dectin-1-deficient C57BL/6 老鼠的危险性在 IL-17A 和芳基烃受体依赖者 IL-22 生产并且在适应 Th1 回答与缺点被联系。相反, dectin-1-deficient BALB/c 鼠标的抵抗与增加的 IL-17A 和 IL-22 生产并且向提供免疫学的存储器的 Th1/Treg 有免疫力的回答扭曲被联系。迥异的正规 / 不在经典中的 NF-κ dectin-1 下游地表明小径的 B 在二不同老鼠紧张被激活。因此,在抗真菌的 mucosal 免疫的 dectin-1 的网活动依赖于主人的基因背景,它在 dectin-1 发信号之上影响天生的 cytokine 生产和适应 Th1/Th17 房间激活。 | Agostinho Carvalho Gloria Giovannini AntoneUa De Luca Carmen D'Angelo Andrea Casagrande Rossana G Iannitti Giovanni Ricci Cristina Cunha Luigina Romani | 2012 | Cellular & Molecular Immunology2012，9，3： | 10 |
| 3 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 4 | Contraction stress and physical properties development of a resin- based composite irradiated using modulated curing meth- ods at two C-factor levels 显示文摘 | Cunha L G Alonso R C Pfeifer C S | 2008 | Dent Mater2008，24，3： | 1 |
| 5 | Monte Carlo code for high spatial resolution ocean color simulations显示文摘 | Alimonte D Zibordi G Kajiyama T Cunha J | | 0，，26： | 1 |
| 6 | Flavonoid glyeosides from leaves and flowers of Bauhinia forficate (Leguminosae) 显示文摘 | Pizzolatti M G Cunha A J Szpoganiez B | 2003 | Quimica Nova2003，26，4： | 1 |
| 7 | Corrosion behaviour of rebars in fly ash mortar exposed to carbon dioxide and chlorides 显示文摘 | MONTEMOR M F CUNHA M P FERREIRA M G | 2002 | Cem & Concr Compos2002，24，： | 1 |
| 8 | Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration显示文摘 | DA CUNHA A A FERREIRA A G WYSE A T | 2010 | Metab Brain Dis2010，25，2： | 1 |
| 9 | Two Pseudomonas Syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis 显示文摘 | KIM M G DA CUNHA L MCFALL A J | 2005 | Cell2005，121，5： | 1 |
| 10 | Fish off flavor analysis by hcadspace and off line purge-and-trap followed by HRGC MS 显示文摘 | Santos G V Da Cunha Veloso M C De Paula Pereira PA | 2001 | American Lab-oratory2001，33，24： | 1 |
| 11 | Novel direct synthesis of L-phenylalanine methyl ester by using Rhodotorula glutinis phenylalanine ammonia lyase in an organic-aqueous biphasic system 显示文摘 | D'Cunha G B Satyanarayan V Nair P M | 1994 | Enzyme Microb Technol1994，16，： | 1 |
| 12 | IFN-gamma limits Th9-mediated autoimmune inflammation through dendritic cell / modulation of IL-27 显示文摘 | MURUGAIYAN G BEYNON V PIRES DA CUNHA A | 2012 | J Immunol2012，189，11： | 1 |
| 13 | M-mode and two-dimensional eehocardiographic features in cardiac amyloidosis显示文摘 | SIQUIERA-FILHO A G CUNHA C L TAJIK A J | 1981 | Circulation1981，63，： | 1 |
| 14 | Novel direct synthesis of L- Phenylalanine methyl ester by using Rhodotorula gtutinis phenylalanine ammonia lyase in an organic-aqueous biphasic system显示文摘 | D' Cunha G B Satyanarayan V Nair P M | 1994 | Enzyme Microbial Technology1994，16，： | 1 |
| 15 | Morphogenesis of ductal networks in the mouse prostate显示文摘 | Sugimura Y Cunha G Donjacour AA | 1986 | Biol Reprod1986，34，5： | 1 |
| 16 | Glutamate system,amyloidβpeptides and tau protein:functional interrelationships and relevance to Alzheimer disease pathology显示文摘 | CUNHA C AVERSA F BISTONI G | 2013 | J Psychiatry Neurosci2013，38，1： | 1 |
| 17 | The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdooCfii oleo-resin 显示文摘 | COSTA-LOTUFO L V CUNHA G M A FARIAS P A M | 2002 | Toxicon2002，40，： | 1 |
| 18 | Nervegrovoth factor,ganglionside and vitamin Eyeverse glutamate cytotoxicity in hippocampal cells显示文摘 | Cunha G M Moraes R A Moraes G A | 1999 | Eur J pharmacol1999，367，1： | 1 |
| 19 | Recovery of ^137Cs From Acidic Fission Products Solutions显示文摘 | Cunha I I L Andrade e Silva L G | 1986 | J Radio anal Nucl Chem Letters1986，105，5： | 1 |
| 20 | Corrosion behaviour of rebars in fly ash mortar exposed to carbon dioxide and chlorides 显示文摘 | Montemor M F Cunha M P Ferreira M G | 2002 | Cement & Concrete Composites2002，24，4： | 1 |
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