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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | Treatment of venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，11： | 1 |
| 3 | Treatment of venous malformations with sclerosant in microfoam form 显示文摘 | Cabrera J Cabrem J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，： | 1 |
| 4 | The TrkC reccplor induces apoptosis when the dependence receplnr notion mets the neu- rotrophin paradigm 显示文摘 | Tauszig-Delamasure S Yu LY Cabrera JR el al | 2007 | Proe Natl Aead Sci U S A2007，104，13： | 1 |
| 5 | Cord blood transplants supported by co-infusion of mobilized hematopoietic stem cells from a third-party donor显示文摘 | Bautista G Cabrera JR Regidor C | 2009 | Bone Marrow Transplant2009，43，5： | 1 |
| 6 | Treatment of venous malformations with sclerosant in microfoam显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，： | 1 |
| 7 | Treatment ofvenousmalformations with sclerosant in microfoam form显示文摘 | Cabrera JjCabrera 3 Jr Garcia-01medoMA | 2003 | ArchDermatol2003，139，11： | 1 |
| 8 | Treatment of venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia -Olmedo MA | 2003 | Arch Dermatol2003，139，11： | 1 |
| 9 | Treatment of venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，11： | 1 |
| 10 | Treatment of venousmalformations with sclerosant in microfoam form显示文摘 | Cabrera J Jr Garcia Olmedo M A Redondo P | | 0，，11： | 1 |
| 11 | Treatment of venous malformations with selerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，11： | 1 |
| 12 | Treatment of venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Jr Garcia-Olmedo MA Redondo P | | 0，，： | 1 |
| 13 | The TrkC re- ceptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm 显示文摘 | Tauszig-Delamasure S Yu LY Cabrera JR | 2007 | Proc Natl Acad Sci U S A2007，104，13： | 1 |
| 14 | Ephron B3 is an anti-apop- totic ligand that inhibits the dependence receptor functions of E- phA4 receptors during aduh neurogenesis 显示文摘 | Fume C Ricard J Cabrera JR | 2009 | Biochim Biophys Acta2009，1793，2： | 1 |
| 15 | Determinants of indi- vidual engagement in knowledge sharing 显示文摘 | Cabrera Jr Collins W C Salgado J F | 2006 | International Journal of Human Resource Management2006，17，2： | 1 |
| 16 | Treatmentof venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，11： | 1 |
| 17 | Treatment of venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | 2003 | Arch Dermatol2003，139，11： | 1 |
| 18 | EphrinB3 is an anti-apoptotic hg- and that inhibits the dependence receptor functions of EphA4 recep- tors during adult neurogenesis显示文摘 | Fume C Ricard J Cabrera JR | 2009 | Biochim Biophys Acta2009，1793，2： | 1 |
| 19 | Treatment ofvenous malformations with sclerosant in microfoam显示文摘 | CabreraJ Cabrera J Jr Garcia-01medo MA | 2003 | ArchDermatol2003，139，： | 1 |
| 20 | Treatment of venous malformations with sclerosant in microfoam form显示文摘 | Cabrera J Cabrera J Jr Garcia-Olmedo MA | | 0，，11： | 1 |
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