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| 1 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 2 | Recovery and recrystallizati on of the deformed, orderable alloy (Co78Fe22)3V 显示文摘 | Cahn R W Takeyama M Horton J A | 1991 | Mater Res1991，6，： | 1 |
| 3 | Team B :The Trillion-dollar Experiment 显示文摘 | Cahn A | 1993 | Bulletin of the Atomic Scientists1993，49，3： | 1 |
| 4 | Brain volumes in relatives of patients with schizophrenia:A meta-analysis显示文摘 | Boos HBM Aleman A Cahn W | 2006 | Schizophr Res2006，81，： | 1 |
| 5 | A broad spectrum human lung fibroblast derived mitogen is a variant of hepatocyte growth factor显示文摘 | RUBIN J S CAHN A M L BATTARO D P | 1991 | Proc Natl Acad Sci U S A1991，88，2： | 1 |
| 6 | Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among un- treated Argentinean seroconverters 显示文摘 | Soclas ME Sued O Laufer N Lfzaro ME Mingrone H Pryluka D Remondegui C Figueroa MI Cesar C Gun A Turk G Bouzas MB Kavasery R Krolewiecki A P6rez H Salom6u H Cahn P Grupo Argentino de Seroconversi6r Study Group | 2011 | J Int AIDS Soc2011，14，1： | 1 |
| 7 | An in situ observation of dislocated (111) glide of NizAITi in a three phase alloy 显示文摘 | YANG R LEAKE J A CAHN R W | 1991 | Scr Metall1991，25，： | 1 |
| 8 | Hypoxiainduced synthesis of hemoglobin in the crustacean Daphnia magna is hypoxia-inducible factor-dependent 显示文摘 | GORR T A CAHN J D YAMAGATA H | 2004 | J Biol Chem2004，279，36： | 1 |
| 9 | Microstructural evolution in two-dimensional two-phase polycrystals显示文摘 | HOLM E A SROLOVITZ D J CAHN J W | | 0，，04： | 1 |
| 10 | A phase 1, randomi- zed, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics 显示文摘 | Hodsman P Ashman C Cahn A et d | 2012 | BrJ Clin Pharmacol2012，75，1： | 1 |
| 11 | The order-disorder transformation in Ni3Al and Ni3Al-Fe alloys (I):Determination of the transition temperatures and their relation to ductility显示文摘 | CAHN R W SIEMERS P A GEIGER J E BARDHAN P | 1987 | Acta Metall1987，35，11： | 1 |
| 12 | Partial substitution of di-and tripeptides for native proteins in sea bass diets improves dicentrarchus labrax larval development显示文摘 | Infante J L Z Cahn C L Peres A | 1997 | Journal of Nutrition1997，127，4： | 1 |
| 13 | Emerging gliptins for type 2 diabetes显示文摘 | Cahn A Raz I | 2013 | Expert Opinion on Emerging Drugs2013，18，2： | 1 |
| 14 | Superiority of 'triple' therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD显示文摘 | Singh D Brooks J Hagan G Cahn A O'Connor B J | 2008 | Thorax2008，63，： | 1 |
| 15 | Detection of dementia of the Alzheimer type in a population - based sample:neuropsychological test performance 显示文摘 | CAHN D A SALMON D P BITTERS N | 1995 | Journal of the International Neuropsychological Society1995，1，3： | 1 |
| 16 | Efl3cacy and safety of an anti-IL-13 mAb in patients with severe asthma: a randomized trial 显示文摘 | De Boever E H Ashman C Cahn A P | 2014 | J Allergy Clin Immunol2014，133，4： | 1 |
| 17 | Influence of dietary calcium salts and electrolyte balance on the urinary pH,slurry pH and ammonia volatelization from slurry of growing finishing pigs显示文摘 | Cahn T T Aarnink A J A Mroz Z | 1997 | J Anim Sci1997，75，1： | 1 |
| 18 | Permeable collagen-glycosaminoglycan cross-linked copolymers for the study of biological responses of cocultured Sertoli and spermatogenic cells显示文摘 | TRES L L CAHN F KIERSZENBAuM A L | 1992 | Cell Biol Toxicol1992，8，3： | 1 |
| 19 | Shape evolution by surface diffusion and surface attachment limited kinetics completely faceted surfaces显示文摘 | Carter W C Roosen A R Cahn J W | 1995 | Acta Metallurgica Materialia1995，43，12： | 1 |
| 20 | Detection and imaging of He2 molecules in superfluid helium显示文摘 | Rellergert WG Cahn SB Garvan A | 2008 | Phys Rev Lett2008，100，02： | 1 |
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