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| 1 | Metal-organic frameworks nanoswitch:Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference显示文摘Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery.Herein,a novel photo-controllable metal-organic frameworks(MOFs)nanoswitch is rationally designed for enhancing small interfering RNA(siRNA)delivery.One single laser triggers the“off-to-on”switching of MOFs nanocomplexes,inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ions,which cooperatively contribute to remarkable endo/lysosomal rupture(∼90%).The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer therapy.Notably,the“off-to-on”switching also activates fluorescence recovery for real-time monitoring siRNA delivery.The nanoswitch could easily be extended to deliver other therapeutic agents(e.g.,DNA,protein,anticancer drug)for overcoming endo/lysosomal entrapment. | Gan Lin Yang Zhang Long Zhang Junqing Wang Ye Tian Wen Cai Shangui Tang Chengchao Chu JiaJing Zhou Peng Mi Xiaoyuan Chen Gang Liu | 2020 | Nano Research2020，13，1： | 5 |
| 2 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 3 | Carbon dioxide adsorption on poly(vinylidene chloride)-based carbons with ultrahigh microporosities prepared by facile carbonization 显示文摘 | Cai Junqing Lü Xiaoxia Xing Yanlong | 2014 | Mater Lett2014，114，1： | 1 |
| 4 | Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer显示文摘 | Junqing Chen Wei Tian Hongke Cai Haifei He Yongchuan Deng | 2012 | Medical Oncology2012，，4： | 1 |
| 5 | Thermogravimet- ric analysis and kinetics of coal/plastic blends during co-pyrolysis in nitrogen atmosphere 显示文摘 | Junqing Cai Yiping Wang Limin Zhou | 2008 | Fule Processing Technology2008，89，1： | 1 |
| 6 | Thermogravi- metric analysis and kinetics of coal/plastic blends during copyrolysis in nitrogen atmosphere 显示文摘 | CAI Junqing WANG Yiping ZHOU Limin | 2008 | Fuel Processing Technology2008，89，1： | 1 |
| 7 | Thermogravimetric analysis and kinetics of coal/plastic blends during co-pyrolysis in nitrogen atmosphere显示文摘 | Junqing Cai Yiping Wang Limin Zhou Qunwu Huang | 2007 | Fuel Processing Technology2007，，1： | 1 |
| 8 | A Novel Aquila Optimizer Based PV Array Reconfiguration Scheme to Generate Maximum Energy under Partial Shading Condition显示文摘This paper develops a real-time PV arrays maximum power harvesting scheme under partial shading condition(PSC)by reconfiguring PV arrays using Aquila optimizer(AO).AO is based on the natural behaviors of Aquila in capturing prey,which can choose the best hunting mechanism ingeniously and quickly by balancing the local exploitation and global exploration via four hunting methods of Aquila:choosing the searching area through high soar with the vertical stoop,exploring in different searching spaces through contour flight with quick glide attack,exploiting in convergence searching space through low flight with slow attack,and swooping through walk and grabbing prey.In general,PV arrays reconfiguration is a problem of discrete optimization,thus a series of discrete operations are adopted in AO to enhance its optimization performance.Simulation results based on 10 cases under PSCs show that the mismatched power loss obtained by AO is the smallest compared with genetic algorithm,particle swarm optimization,ant colony algorithm,grasshopper optimization algorithm,and butterfly optimization algorithm,which reduced by 4.34%against butterfly optimization algorithm. | Dong An Junqing Jia Wenchao Cai Deyu Yang Chao Lv Jiawei Zhu Yingying Jiao | 2022 | Energy Engineering2022，119，4： | 0 |
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