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| 1 | Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver显示文摘AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury. | Fahrettin Yildiz Sacit Coban Alpaslan Terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak Muharrem Bitiren | 2008 | World Journal of Gastroenterology2008，14，33： | 8 |
| 2 | Comparison of one and three initial monthly intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion显示文摘AIM: To compare three initial monthly intravitreal ranibizumab(IVR) injections followed by pro re nata(PRN) dosing with one initial monthly IVR injections followed by PRN dosing for macular edema(ME) secondary to branch retinal vein occlusion(BRVO).METHODS: Forty-two eyes of 42 patients who had IVR injections for BRVO were retrospectively studied. Eighteen eyes received 1 initial IVR injection(1+PRN group) and 24 eyes received 3 monthly IVR injections(3+PRN). At 1, 3, 6 and 12mo; spectral-domain optical coherence tomography(SD-OCT) was performed. Central macular thickness(CMT), the integrity of the external limiting membrane(ELM), the presence of subretinal fluid, cyst size, the presence of inner segment/outer segment(IS/OS) defect were determined.RESULTS: At baseline the mean CMT was 521.3±153.2 μm in the 3+PRN group while it was 438.1±162.4 μm in 1+PRN group. At the final visit, mean CMT was 278.3±87.8 μm in the 3+PRN group and 285.2±74.2 μm in the 1+PRN group(P=0.079). The changes in CMT over the entire study period were also comparable in both groups(243±160 μm in the 3+PRN group, and 152.9±175.3 μm in the 1+PRN group; P=0.090). At baseline, best-corrected visual acuity(BCVA) was 0.92±0.60 logarithm of the minimal angle of resolution(logMAR) in the 3+PRN group, while it was 0.72±0.46 logMAR in the 1+PRN group. Final BCVA was 0.42±0.55 logMAR in the 3+PRN group and 0.38±0.50 logMAR in the 1+PRN group(P=0.979). Additionally, the BCVA changes from baseline to final visit were not significantly different(-0.50±0.45 logMAR in the 3+PRN group, and-0.33±0.39 logMAR in the 1+PRN group; P=0.255).CONCLUSION: No significant differences in the anatomical or functional results are found between 3+PRN and 1+PRN regimens in the patients receiving ranibizumab for ME secondary to BRVO. Intact IS/OS and baseline BCVA are good predictor of the visual gain, while baseline CMT is a good predictor of the anatomical gain. | Alper Halil Bayat Akin Cakir Seyma Gülcenur Ozturan Selim Bolükbasi Burak Erden Mustafa Nuri Elcioglu | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 6 |
| 3 | Impacts of low-intensity prescribed fire on microbial and chemical soil properties in a Quercus frainetto forest显示文摘Prescribed fire is a common economical and effective forestry practice, and therefore it is important to understand the effects of fire on soil properties for better soil management. We investigated the impacts of low-intensity prescribed fire on the microbial and chemical properties of the top soil in a Hungarian oak(Quercus frainetto Ten.) forest. The research focused on microbial soil parameters(microbial soil respiration(RSM), soil microbial biomass carbon(Cmic) and metabolic quotient(qCO_2) and chemical topsoil properties(soil acidity(pH),electrical conductivity(EC), carbon(C), nitrogen(N), C/N ratio and exchangeable cations). Mean annual comparisons show significant differences in four parameters(C/N ratio,soil pH, Cmic and qCO_2) while monthly comparisons do not reveal any significant differences. Soil pH increased slightly in the burned plots and had a significantly positive correlation with exchangeable cations Mg, Ca, Mn and K.The mean annual C/N ratio was significantly higher in the burned plots(28.5:1) than in the control plots(27.0:1). The mean annual Cmic(0.6 mg g^(-1)) was significantly lower although qCO_2(2.5 lg CO_2–C mg Cmic h^(-1)) was significantly higher, likely resulting from the microbial response to fire-induced environmental stress. Low-intensity prescribed fire caused very short-lived changes. The annual mean values of C/N ratio, pH, Cmic and qCO_2 showed significant differences. | Serdar Akburak Yowhan Son Ender Makineci Meric Cakir | 2018 | Journal of Forestry Research2018，29，3： | 6 |
| 4 | 吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系(英文)显示文摘目的:研究老年性黄斑变性(AMD)等级、血清抗氧化维生素水平(维生素A、C和E)和吸烟的关系。方法:对84例患者行黄斑彩色眼底成像,根据AMD损伤率和损伤程度将其分为五组(等级I^V)。应用高效液相色谱法(HPLC)测量血清抗氧化维生素水平。根据吸烟状况分不吸烟者、已戒烟者和吸烟者三组,并统计吸烟者每年的吸烟总量。结果:对照组中,维生素A、E、C水平分别为0.874±0.326mg/L,10.739±4.874mg/L和1.737±0.447mg/L,AMD组中分别为0.880±0.305mg/L,9.487±6.060mg/L和1.870±2.191mg/L,无显著差异(P>0.05)。AMD不同等级分组间维生素A(P=0.881)和E(P=0.293)水平差异无统计学意义,维生素C水平(P=0.044)随AMD程度的加深而增加。根据吸烟状况,AMD组与对照组之间无显著差异。根据每年的吸烟总量,两组之间有显著差异(P=0.02)。AMD越严重,年吸烟总量越高(P=0.007)。结论:研究结果显示AMD与维生素A、E血清水平无关,但和维生素C的血清水平相关,并与吸烟量有关。 | Sezen Akkaya Cakir Ozlem Sahin Haluk Kazokoglu Feyza Tekeli Goncagul Haklar Yelda Ozkurt | 2014 | 国际眼科杂志2014，14，5： | 5 |
| 5 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 6 | The Prognostic Value of Neuron-Specific Enolase in Head Trauma Patients显示文摘 | Emine Meric Abdulkadir Gunduz Suleyman Turedi Ertugrul Cakir Mustafa Yandi | 2010 | Journal of Emergency Medicine2010，，3： | 3 |
| 7 | 修复胸椎椎弓根螺钉致胸主动脉损伤的时机:3例新病案报告并文献综述显示文摘胸椎椎弓根螺钉内固定的主要适应证为胸椎骨折和脊柱侧凸/后凸。椎弓根螺钉置入时经由椎体后柱、中柱到达前柱,所经之处毗邻重要组织,严重并发症发生风险大。椎弓根螺钉引起的主动脉损伤罕见,一旦发生穿孔需急诊行主动脉修复手术。然而,在胸椎椎弓根螺钉并未穿破主动脉壁的情况下,是否需要修补主动脉,目前尚不明确。本文通过检索MEDLINE/Pubmed收集了19个病例,结合本研究的3个病例(图1~3),对撞击主动脉但主动脉壁未穿孔情况下修复主动脉的适应证和时机加以分析。 | Kayaci S Cakir T Dolun M 葛苏 马向阳 | 2019 | 中国骨科临床与基础研究杂志2019，11，4： | 2 |
| 8 | In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells显示文摘电压门钠隧道(VGSC ) 活动提高与转移有关的房间行为,例如活动性,侵略,和 oncogene 表示。新生的选择拼接 Nav1.5 isoform 的形式在变形乳癌被表示。而且,异常槽口发信号小径能导致 oncogenesis 并且可以支持乳癌的前进。在这研究,我们试图分析 nNav1.5 禁止者 phenytoin 和槽口信号禁止者 N- 的效果[经由分别地发信号的 nNav1.5 VGSC 活动和槽口的抑制的三倍的否定乳癌房间线(MDA-MB-231 ) 上的 N-(3,5-difluorophenacetyl )-L-alanyl]-S-phenylglycine-t-butyl 酉旨(DAPT ) 。以便决定这些禁止者的单个、联合的效果, 4-[3-(4-iyodophenyl )-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1 ) 测试,创伤愈合试金,和 zymography 被执行检测增长,侧面的活动性,和矩阵 metalloproteinase-9 (MMP9 ) 活动分别地。metalloproteinases-1 (TIMP1 ) 的 nNav1.5, Notch4, MMP9,和织物禁止者的表情被量的即时反向的 transcriptasepolymerase 链反应也检测。当剂量比 10 眠獡 ? ┵高时, DAPT 引起了 antiproliferative 效果吗?? | Canan Cakir Aktas N. Dilara Zeybek A. Kevser Piskin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 2 |
| 9 | Quantitative proton MR specttroseopy fingings in the corpus callosum of patients with Schizophrenia suggest eallosal disconnection 显示文摘 | AYDIN K UCOK A CAKIR S | 2007 | AJNR Ant J Neuroradiol2007，28，10： | 1 |
| 10 | A finite method for the singularly perturbed problem with nonlocal boundary condition显示文摘 | CAKIR M AMIRALIYEV G M | 2005 | Applied Mathematics and Computation2005，160，2： | 1 |
| 11 | Computer-assisted posterior instrumentation of the cervical and cervico-thoracic spine显示文摘 | Mattes T Cakir B | 2004 | Euro-Spine J (2004) 13:50-592004，，2004： | 1 |
| 12 | Flexible bronchoscopy for diagnosis and follow up of childhood endobronchial tuberculosis 显示文摘 | Cakir E Uyan ZS Oktem S | 2008 | Pediatr In- fect Dis J2008，27，： | 1 |
| 13 | A comparison of three different intravitreal treatment modalities of macular edema due to branch retinal vein occlusion 显示文摘 | Cekic O Cakir M Yazici AT | 2010 | Curr Eye Res2010，35，： | 1 |
| 14 | The efficacy of apparent diffusioncoefficient value calculation in differentiation between malignantand benign thyroid nodules显示文摘 | Dilli A Ayaz UY Cakir E | 2012 | Clin Imaging2012，36，： | 1 |
| 15 | Diffusion weighted magnetic resonance imaging for the characterization of solitary pulmonary lesions显示文摘 | CAKIR C GENCHELLAC H TEMIZOZ O | 2015 | Balkan Med 12015，32，4： | 1 |
| 16 | Effect of water stress at different development stages on vegetative and reproductive growth of corn显示文摘 | Cakir R | 2004 | Field Crops Re- search2004，89，1： | 1 |
| 17 | Pleural fluid and serum procalcitoni n as diagnostic tools in tuberculous pleurisy显示文摘 | Cakir E Deniz O Ozcan O | 2005 | Clin Biochem2005，38，3： | 1 |
| 18 | Antifungal,phytotoxic and insecticidal properties of essential oil isolated from Turkish Origanum acutidens and its three components,carvacrol,thymol and p-cymene显示文摘 | Kordali S Cakir A Ozer H | 2008 | Bioresource Technology2008，99，18： | 1 |
| 19 | Sarcomas: rare primary malignant tumors of the thorax 显示文摘 | Cakir O Topal U Bayram AS | 2005 | Diagn Interv Radiol2005，11，1： | 1 |
| 20 | MRI findings of Wernicke encephalopathy revisited due to hunger strike显示文摘 | Unlu E Cakir B Asil T | 2006 | Eur J Radiol2006，57，1： | 1 |
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