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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | The effect of propolis and its components on eicosanoid production during the inflammatory response 显示文摘 | Mirzoeva O K Calder P C | 1996 | Prostaglandins Leukotrienes Essent Fatty Acids1996，55，6： | 1 |
| 3 | Evolution of FLASH, a multi-physics scientific simulation code for high-performance computing 显示文摘 | Dubey A Antypas K Calder A C | 2014 | International Journal of High Performance Computing Applications2014，28，2： | 1 |
| 4 | The role of the striatum in the mouse in behavioral sensitization to amphetamine 显示文摘 | Bedingfield JB Calder LD Thai D K | 1997 | Pharmacol Biochem Behav1997，56，： | 1 |
| 5 | Teachers developing assessments of early literacy : A community of practice project 显示文摘 | Perry N E Walton C & Calder K | 1999 | Teacher Education and Special Education1999，22，4： | 1 |
| 6 | Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years显示文摘 | PIKE K C CALDER P C INSKIP H M | 2012 | Clin Dev Immunol2012，2012，47： | 1 |
| 7 | Somicrobial commumity composition and land use history icultivated and grassland ecosystems of coastal California显示文摘 | STEENWERTH K L JACKSON L E CALDER(O)N F J | 2002 | Soil Biology& Biochemistry2002，34，： | 1 |
| 8 | Eucalyptus water use greater than rainfall input-a possible explanation from southern India显示文摘 | Calder I R Rosier P T W Prasanna K T | 1997 | Hydrology and Earth System Sciences1997，1，2： | 1 |
| 9 | Hydrological impact of Eucalyptus plantation in India 显示文摘 | CALDER I R HALL R L PRASANNA K T | 1993 | Journal of Hydrology1993，150，： | 1 |
| 10 | Vibrio parahaemolyticus cell biology and pathogenicity determinants显示文摘 | Broberg CA Calder T J Orth K | 2011 | Microbes Infect2011，13，1213： | 1 |
| 11 | Vibrio p arahaemolyticus cell biology and pathogenicity determinants 显示文摘 | Broberg CA Calder TJ Orth K | 2011 | Microbes Infect2011，13，1213： | 1 |
| 12 | On estimating air pullution concentrations from a oblique wind显示文摘 | Calder K L | 1973 | Atmo Environ1973，23，7： | 1 |
| 13 | Vibrio parahaemolyticus cell biology and pathogenicity determinants 显示文摘 | Broberg CA Calder TJ Orth K | 2011 | Microbes Infect2011，13，1213： | 1 |
| 14 | Peat formation in a Westphalian B piedmont setting, Cumberland basin, Nova Scotia: implications for the maceral-based interpretation of rheotrophic and raised paleomires显示文摘 | CALDER J H GIBLING M R MUKHOPADHYAY P K | 1991 | Geology Bull1991，162，： | 1 |
| 15 | Hydrocarbon generation from deltaic and intermontane fluviodeltaic coal and coaly shale from the Tertiary of Texas and Carboniferous of Nova Scotia 显示文摘 | Mukhopadhyay P K Hatcher P G Calder J H | 1991 | Org Geochem1991，17，6： | 1 |
| 16 | An outbreak of hepatitis A associated with consumption of raw blueberries显示文摘 | Calder L Simmons G Thornley C Taylor P Pritchard K Greening G Bishop J | 2003 | Epidemiol Infect2003，131，： | 1 |
| 17 | Identi fication and estimation o{ neutral organic contami nants in potable water 显示文摘 | Burnham A K Calder G V Fritz J S | 1972 | Analytical Chemistry1972，44，13： | 1 |
| 18 | A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis显示文摘 | Gupta R Patel K Calder P C | 2003 | Pancreatology2003，3，： | 1 |
| 19 | A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II > or = 6) 显示文摘 | Gupta R Patel K Calder PC | 2003 | Pancreatology2003，3，5： | 1 |
| 20 | A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II > or =6)显示文摘 | Gupta R Patel K Calder PC | 2003 | Pancreatology2003，3，5： | 1 |
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