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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Somicrobial commumity composition and land use history icultivated and grassland ecosystems of coastal California显示文摘 | STEENWERTH K L JACKSON L E CALDER(O)N F J | 2002 | Soil Biology& Biochemistry2002，34，： | 1 |
| 3 | Hydrological impact of Eucalyptus plantation in India 显示文摘 | CALDER I R HALL R L PRASANNA K T | 1993 | Journal of Hydrology1993，150，： | 1 |
| 4 | On estimating air pullution concentrations from a oblique wind显示文摘 | Calder K L | 1973 | Atmo Environ1973，23，7： | 1 |
| 5 | An outbreak of hepatitis A associated with consumption of raw blueberries显示文摘 | Calder L Simmons G Thornley C Taylor P Pritchard K Greening G Bishop J | 2003 | Epidemiol Infect2003，131，： | 1 |
| 6 | A comparative study of the turbulent Rayleigh-Taylor instability using high-resolution three-dimensional numerical simulations: the Alpha-Group collaboration 显示文摘 | Dimonte G Youngs D L Dimits A Weber S Marinak M Wunsch S Garasi C Robinson A Andrews M J Ramaprabhu P Calder A C Fryxell B Biello J Dursi L MacNeice P Olson K Ricker P Rosner R Timmes F Tufo H Young Y N Zingale M | 2004 | Physics of Fluids2004，16，5： | 1 |
| 7 | Soil microbial community composition and land use history in cultivated and grassland ecosystems of coastal California显示文摘 | Steenwerth K L Jackson L E Calderón F J | 2002 | Soil Biology and Biochemistry2002，34，11： | 1 |
| 8 | Motor Unit Potential Morphology Differences in Individuals with Non-Specific Arm Pain and Lateral Epicondylitis显示文摘 | Calder K M Stashuk D W Mclean L | 2008 | J Neuroeng Rehabil( S1743-0003 )2008，5，： | 1 |
| 9 | Microbial response to simulated tillage in cultivated and uncultivated soils 显示文摘 | Calderón J F Jackson L E Scow K M | 2000 | Soil Biology and Biochemistry2000，32，： | 1 |
| 10 | The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine显示文摘 | Karler R Calder L D Thai D K | 1998 | Pharmacol Biochem Behav1998，60，1： | 1 |
| 11 | Hydrological impact of Eucalyptus plantation in India显示文摘 | CALDER I R HALL R L PRASANNA K T | 1993 | Journal of Hydrology1993，150，234： | 1 |
| 12 | Microbial responses to simulated tillage in cultivated and uncultivated soils显示文摘 | Calderón F J Jackson L E Scow K M | 2000 | Soil Biology & Biochemistry2000，32，11： | 1 |
| 13 | The evolutionarily conserved Arabidopsis thaliana F-box protein AtFBP7 is required for efficient translation during temperature stress显示文摘 | Calderón-Villalobos L I Nill C Marrocco K | 2007 | Gene2007，392，12： | 1 |
| 14 | Atmospheric diffusion of particulate material, considered as a boundary value problem显示文摘 | | 1961 | J Met1961，18，2： | 1 |
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