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| 1 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 2 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 3 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 4 | Simultaneous high-biomass protein production and nutrient removal using spirulina maxina in sea watersupplemented with anaerobic effluents 显示文摘 | Olguin E J Galacia S Camacho R | 1994 | World Journal of Microbiology & Biotechnology1994，，10： | 1 |
| 5 | Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cell:Relationship with electronegative LDL显示文摘 | Benitez S Camacho M Arcelus R Vila L Bancell C Ordonez-Llanos J | 2004 | Atherosclerosis2004，177，2： | 1 |
| 6 | Human EAG1 potassium channels in the epithelial-to-mesenchymal transition in lung cancer cells 显示文摘 | Restrepo-Angulo I S~mchez-Torres C Camacho J | 2011 | Anticancer Res2011，31，4： | 1 |
| 7 | Phase I/II trial of tremelimumab in patients with metastatic melanoma显示文摘 | Camacho LH Antonia S Sosman J | 2009 | J Clin Oncol2009，27，7： | 1 |
| 8 | Quality-determination of recycled plastic packaging waste by identification of contaminants by GC-MS after microwave assisted extraction(MAE)显示文摘 | Camacho W Karlsson S | 2000 | Polymer Degradation and Stability2000，71，1： | 1 |
| 9 | Leukocytosisi and the retinoic acid syndrome in patient swith acute promyelocytic leukemia treated with arsenic trioxide显示文摘 | Camacho LH Soignet S L Chanel S | 2000 | Clin Oncol2000，18，13： | 1 |
| 10 | Phase I/II trial of tremelimumab in patients with metastatic melanoma 显示文摘 | Camacho LH Antonia S Sosman J | 2009 | J Clin Oncol2009，27，7： | 1 |
| 11 | Ki- neticsofaerobictreatmentofolive-millwastewater (OMW) with Aspergillus terreus显示文摘 | Garrido Hoyos S E Martinez Nieto L Camacho Rubio F | 2002 | Process Biochemistry2002，37，： | 1 |
| 12 | Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome显示文摘 | Maslak P Chanel S Camacho LH | 2006 | Leukemia2006，20，2： | 1 |
| 13 | Minimization of sludge production in biological processes:An alternative solution for the problem of sludge disposal显示文摘 | Camacho P Deleris S Geaugey V | 2002 | Water Science and Technology2002，46，10： | 1 |
| 14 | Wear of a Chute in a Rice Sorting Machine显示文摘 | CAMACHO J LEWIS R DWYER-JOYCE R S | 2007 | Wear2007，263，123456： | 1 |
| 15 | Rectal hyposensitivity for non-noxious stimuli, postprandial hypersensitivity and its correlation with symptoms in complete spinal cord injury with neurogenic bowel dysfunction 显示文摘 | Awad RA Santillhn MC Camacho S | 2013 | Spinal Cord2013，51，2： | 1 |
| 16 | Useful- ness of B-type natriuretic peptide and N-terminal pro-B type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease 显示文摘 | Lowenthal A Camacho BV Lowenthal S | 2012 | AmJCardiol2012，109，6： | 1 |
| 17 | Identification and characterization of an amino acid transporter expressed dif- ferentially in liver显示文摘 | GU S RODERICK H L CAMACHO P | 2000 | Proc Natl Acad Sci USA2000，97，7： | 1 |
| 18 | Useful-ness of B-type natriuretic peptide and N-terminal pro-B type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease显示文摘 | Lowenthal A Camacho BV Lowenthal S | 2012 | American Journal of Cardiology2012，10，06： | 1 |
| 19 | Simultaneous high - biomass protein production and nutrient removal using Spirulina maxina in sea water supplemented with anaerobic effluents显示文摘 | Olguin E J Galacia S Camacho R | 1994 | World Journal of Microbiology & Biotechnology1994，10，： | 1 |
| 20 | A Mechanistic model of photosynthesis in microalgae显示文摘 | Camacho R F Fernandez S J Chisti M Y | 2003 | Biotechnology and Bioengineering2003，81，4： | 1 |
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