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| 1 | The chemokines CXCL8 and CXCL12:molecular and functional properties,role in disease and efforts towards pharmacological intervention显示文摘Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes.CxCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue injury.CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2,the atypical chemokine receptor ACKR1,and glycosaminoglycans.Furthermore,(hetero)dimerization and tight regulation of transcription and translation,as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and cancer.The CxCL8 interaction with receptors and glycosaminoglycans is therefore a promising target for therapy,as illustrated by multiple ongoing clinical trials.CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12,which retains leukocytes in bone marrow.CXCL12 is primarily a homeostatic chemokine that induces migration and activation of hematopoietic progenitor cells,endothelial cells,and several leukocytes through interaction with CXCR4,ACKR1,and ACKR3.Thereby,it is an essential player in the regulation of embryogenesis,hematopoiesis,and angiogenesis.However,CXCL12 can also exert inflammatory functions,as illustrated by its pivotal role in a growing list of pathologies and its synergy with CXCL8 and other chemokines to induce leukocyte chemotaxis.Here,we review the plethora of information on the CXCL8 structure,interaction with receptors and glycosaminoglycans,different levels of activity regulation,role in homeostasis and disease,and therapeutic prospects.Finally,we discuss recent research on CXCL12 biochemistry and biology and its role in pathology and pharmacology. | Seppe Cambier Mieke Gouwy Paul Proost | 2023 | Cellular & Molecular Immunology2023，20，3： | 4 |
| 2 | The integrin alpha(v)beta8mediates epithelial homeostasis through MT1-MMP-dependent activationof TGF-betal显示文摘 | Mu D Cambier S Fjellbirkeland L | 2002 | J Cell Biol2002，157，3： | 1 |
| 3 | Computational methods for accounting of structural uncertainties, applications to dynamic behavior prediction of piping systems显示文摘 | Cambier S Guihot P Coffignal G | 2002 | Structural Safety2002，24，： | 1 |
| 4 | Open versus closed kinetic chain exercises in patellofemoral pain a 5-year prospective randomized study显示文摘 | Witvrouw E Danneels L Cambier D | | 0，，： | 1 |
| 5 | Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4 显示文摘 | Ott VL Cambier JC Kappler J | 2003 | Nat lmmunol2003，4，： | 1 |
| 6 | Funetionalized clay heterostmctures for reducing cadmium and lead uptake by plants in contaminated soils显示文摘 | Diaz M Cambier P Brendlé J | 2007 | Applied Clay Science2007，37，： | 1 |
| 7 | BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner 显示文摘 | Cambier N Chopra R Strasser A | 1998 | Oncogene1998，16，3： | 1 |
| 8 | CT imaging of trunk muscles in chronic low back pain patients and healthy control subjects 显示文摘 | Danneels LA Vanderstraeten GG Cambier DC | 2000 | Eur Spine J2000，9，4： | 1 |
| 9 | Squamous metaplasia amplifies pathologic epit helial-mesenchymal interactions in COPD patients显示文摘 | Araya J Cambier S Markovics JA | | 0，，： | 1 |
| 10 | Signal transduction by the B cell antigen receptor and its coreceptors 显示文摘 | Cambier JC Pleiman CM Clark MR | 1994 | A Rev Immun1994，12，： | 1 |
| 11 | Investigation of minimal residual disease in adult Ph1 positive acute lymphoblastic leukemia by a combination of cell sorting and fouorescence in situ hybridization:a preliminary study on 6 cases显示文摘 | Cambier N Soenen CV Lai JL | 2000 | Haematologica2000，85，： | 1 |
| 12 | Physiopathologic mechanisms of coma显示文摘 | MASSON C CAMBIER J MASSOM M | 1989 | Rev Prat1989，39，： | 1 |
| 13 | Percutaneous closure of the smalt patent ductus arteriosus using coil embolization显示文摘 | Cambier P A Kirby W C Worthcm D C | 1992 | Am J Cariol1992，69，8： | 1 |
| 14 | B-cell anergy: from transgenic models to naturally occurring anergic B cells 显示文摘 | Cambier JC Gauld SB Merrell KT | 2007 | Nat Rev Immunol2007，7，： | 1 |
| 15 | Cerantic toughness as- sessment through edge chipping measurements-influence of interfacial friction 显示文摘 | Petit F Vandeneede V Cambier F | 2009 | Journal of the European Cera- mic Society2009，29，11： | 1 |
| 16 | Extrinsic risk factors for compromised blood flow in the vertebral artery: anatomical observations of the transverse foramina from C3 to C7显示文摘 | Barbara Cagnie Erik Barbaix Elke Vinck Katharina D’Herde Dirk Cambier | 2005 | Surgical and Radiologic Anatomy2005，，4： | 1 |
| 17 | Laparoscopy for Management of Nontraumatic Acute Abdomen显示文摘 | Navez B d'Udekem Y Cambier E | 1995 | World J Surg1995，19，3： | 1 |
| 18 | Integrin ανβ8-mediated activation of transforming growth factor-β inhibits human airway epithelial proliferation in intact bronchial tissue显示文摘 | FJELLBIRKELAND L CAMBIER S BROADDUS V C | 2003 | Am J Pathol2003，163，2： | 1 |
| 19 | Signal transduction by the B Cell antige n receptorand its coreceptors显示文摘 | Cambier JC Pleiman CM Clark MR | 1994 | Ann Rev Immunol1994，12，： | 1 |
| 20 | Dose-escalation study of single dose mitoxantrone incombination with timed sequential chemotherapy in patients with refractory or relapsing acute myelogenous leukemia显示文摘 | THOMAS X CAMBIER N TAKSIN A L | 2000 | Leuk Res2000，24，： | 1 |
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