|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | Response and modeling of cantilever retaining walls subjected to seismic motions显示文摘 | GREEN R A OLGUN C G CAMERON W I | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，4： | 1 |
| 3 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Hysiol2006，290，： | 1 |
| 4 | Intensive care unit-acquired weakness: clinical phenotypes and molecu- lar mechanisms显示文摘 | Batt J Santos C C Cameron J I | 2013 | Am J Respir Crit Care Med2013，187，3： | 1 |
| 5 | Inorganic-N release from spent mushroom compost under laboratory and field conditions 显示文摘 | STEWART D P C CAMERON K C Cornforth I S | 1998 | Soil Biology and Biochemistry1998，30，13： | 1 |
| 6 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 7 | Non-steroidal anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis显示文摘 | Barnes C J Cameron I L Hardman W E | 1998 | Br J Cancer1998，77，3： | 1 |
| 8 | Release of sulphate, potassium, calcium and magnesium from spent mushroom compost under laboratory conditions显示文摘 | STEWART D P C CAMERON K C CORMFORTH I S | 1998 | Biol Fertil Soils1998，26，： | 1 |
| 9 | 1, 3-propane- diol production by Escherichia coli expression genes from the Klebsiella pneumonia dha regulon显示文摘 | Tong I T Liao H H Cameron D C | 1991 | Ap- plied and Environmental Microbiology1991，57，12： | 1 |
| 10 | Reactions to caregiving during an intervention targeting frailty in community living older people 显示文摘 | Aggar C Ronaldson S Cameron I D | 2012 | BMC Geriatrics2012，12，1： | 1 |
| 11 | Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis:a double-blind,randomized,controlled trial显示文摘 | Man C Y Cheung I T Cameron P A | 2007 | Ann Emerg Med2007，49，5： | 1 |
| 12 | Physical exercise after hip fracture: an evidence overview显示文摘 | Sherrington C Tiedemann A Cameron I | 2011 | Eur J Phys Rehabil Meal2011，47，2： | 1 |
| 13 | Risk factors and outcomes in post pancreaticoduodenectomy pancreaticocutanous fistula显示文摘 | Lin J W Cameron J L Yeo C I | 2004 | Gastrointest Surg2004，8，8： | 1 |
| 14 | 1,3-Pro- panediol Production by Escherichia coli Expressing Genes from the Klebsiella pneumoniae dha Regulon 显示文摘 | I the Tong Hans H Liao Douglas C Cameron | 1991 | Applied and Environmental Microbiology1991，57，12： | 1 |
| 15 | Xanthogranuloatous eholecystitis显示文摘 | Collins M C Cameron I | 1994 | Br J Surg1994，81，7： | 1 |
| 16 | A generalized dynamic model for distillation columns Ⅰ:Model description and applications显示文摘 | Gani R Ruiz C A Cameron I T | 1986 | Computers and Chemical Engineering1986，10，3： | 1 |
| 17 | Dermatoscopy in routine practice-'chaos and clues'显示文摘 | Rosendahl C Cameron A McColl I | | 0，，： | 1 |
| 18 | Response and Modeling of Cantilever Retaining Walls Subjected to Seismic Motions显示文摘 | Green R A Olgun C G Cameron W I | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，4： | 1 |
| 19 | Post thaw viability and fumctionality or cryopreserved rat fetal brain cells cocultured with sertoli cells显示文摘 | Cameron D F Othberg A I Borlongan C V | 1997 | Cell Transplant1997，6，2： | 1 |
| 20 | 1,3-Propanediol production by Escherichia coli expressing genes from the Klebsiella pneumoniae dha regulon显示文摘 | Tong I T Liao H Cameron D C | 1991 | Appl Environ Microbiol1991，57，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员