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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Recurrent calcium nephrolithiasis associated with primary aldosteronism 显示文摘 | Shey J Cameron M A Sakhaee K | 2004 | Am J Kidney Dis2004，44，1： | 1 |
| 4 | Novel Cell Culture Device Enabling Three-Dimensional Cell Growth and hnproved Cell Function 显示文摘 | Bokhari M Camachan R J Cameron N R | 2007 | Biochem Biophys Res Comnmn2007，354，4： | 1 |
| 5 | Adenocarcinoma of the esophagogastric junction and Barrett's esophagus 显示文摘 | Cameron A J Lomboy CT Pera M | 1995 | Gastroenterology1995，109，5： | 1 |
| 6 | Induetion of Logic Programs:FOIL and Related System显示文摘 | J R Quinlan R M Cameron | 1995 | New Generation Computation1995，13，： | 1 |
| 7 | Changes in mineral N,microbial biomass and enzyme activity in different soil depths after surface applications of dairy shed effluent and chemical fertilizer显示文摘 | ZAMAN M CAMERON K C DI H J | 2002 | Nutrient Cycling in Agroecosystems2002，63，2： | 1 |
| 8 | Nitrogen minerali- zation rates from soil amended with dairy pond waste 显示文摘 | Zaman M Cameron K C Di H J | 1998 | Aust J Soil Res1998，36，： | 1 |
| 9 | The risk of se-rious adverse outcomes associated with hypoxaemia andhyperoxaemia in acute exacerbations of COPD显示文摘 | Cameron L Pilcher J Weatherall M | 2012 | Post-grad Med J2012，88，1046： | 1 |
| 10 | Aliphatic polyester polymer stars:synthesis,properties and applications in biomedicine and nanotechnology显示文摘 | Cameron D J A Shaver M P | 2011 | Chemical Society Reviews2011，40，3： | 1 |
| 11 | Gross nitrogen mineralizalion and nitrification rates and their relationships to enzyme activities and the soil microbial biomass in soils treated with dairy shed effluent and ammonium fertilizer at different water potentials 显示文摘 | ZAMAN M DI H J CAMERON K C FRAMPTON C M | 1999 | Biology and Fertility of Soils1999，29，： | 1 |
| 12 | 显示文摘 | T H Klusmeyer M R Cameron | 1992 | J Dairy Sci1992，75，： | 1 |
| 13 | Accuracy of field sampling for soil tests显示文摘 | Nyborg M Toogood J A | 1971 | Can J Soil Science1971，51，： | 1 |
| 14 | Does fibrin glue sealant decrease the of pancreatic fistula after pancreaticoduodenectomy Results of a prospect iverandomized trial显示文摘 | Lilemoe K D Cameron J L Kim M P | 2006 | J Gastrointest Surg2006，10，9： | 1 |
| 15 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Hysiol2006，290，： | 1 |
| 16 | Prevalence and sig- nificance of atrial fibrillation in coronary artery disease ( CASS Regis- try) 显示文摘 | Cameron A Schwartz M J Kronmal RA | 2009 | Am JCardiol2009，61，10： | 1 |
| 17 | Evidence for the optimal management of acute and chronic phantom pain: A systematic review显示文摘 | HALBERT J CROTTY M CAMERON I D | 2002 | Clin J Pain2002，18，： | 1 |
| 18 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 19 | Functions outcome af- ter tibial tubercle transfer for the painful patella alta 显示文摘 | AL-Sayyad M J Cameron JC | 2002 | Clin Orthop Relat Res2002，，396： | 1 |
| 20 | Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activation with anti-CD3 and interleukin-2显示文摘 | Chang A E Aruga A Cameron M J | 1997 | J Clin Oncol1997，15，2： | 1 |
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