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| 1 | Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease?显示文摘The anemia of chronic kidney disease and hemodialysis is characterized by chronic inflammation and release of cytokines,resulting in the upregulation of the iron hormone hepcidin,also increased by iron therapy and reduced glomerular filtration,with consequent reduction in iron absorption,recycling,and availability to the erythron.This response proves advantageous in the short-term to restrain iron availability to pathogens,but ultimately leads to severe anemia,and impairs the response to erythropoietin(Epo)and iron.Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores,thereby resulting in inadequate inhibition of the activity of Ferroportin-1,inappropriately high iron absorption and recycling,and iron overload.However,in hemodialysis patients,carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation,thereby improving iron availability to erythropoiesis,anemia control,the response to Epo,and possibly survival.Therefore,anti-hepcidin therapies may improve anemia management in hemodialysis.However,HFE mutations directly favor hemoglobinization independently of hepcidin,and reduce macrophages activation in response to inflammation,whereas hepcidin might also play a beneficial anti-inflammatory and anti-microbic action during sepsis,so that direct inhibition of HFEmediated regulation of iron metabolism may represent a valuable alternative therapeutic target.Genetic studies may offer a valuable tool to test these hypotheses and guide the research of new therapies. | Elena Canavesi Carlo Alfieri Serena Pelusi Luca Valenti | 2012 | World Journal of Nephrology2012，1，6： | 5 |
| 2 | HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Luca Valenti Anna Ludovica Fracanzani Elisabetta Bugianesi Paola Dongiovanni Enrico Galmozzi Ester Vanni Elena Canavesi Ezio Lattuada Giancarlo Roviaro Giulio Marchesini Silvia Fargion | 2010 | Gastroenterology2010，，3： | 4 |
| 3 | Anti-atherothrombotic and anti-inflammatory properties of rosuvastatin in ApoE-deficient mice显示文摘 | Canavesi M Monetti M | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 4 | Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterol patients显示文摘 | Lovati MR Manzoni C Canavesi A | 1987 | Clin Invest1987，80，7： | 1 |
| 5 | HMG-CoA reduetase inhibitors reduce MMP-9 secretion by macrophages显示文摘 | Bellota S Via D Canavesi M | 1998 | Arteroseler Thlomb Vasc Biol1998，18，11： | 1 |
| 6 | HM G2COA reductase inhibitons reduce MM P29 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | | 0，，： | 1 |
| 7 | HMG-CoA reductase inhibitors reduce MMP-9 secretion by marcophages显示文摘 | Bellosta S ViaD Canavesi P | 1998 | Arteroscler Thromb Vasc Biol1998，18，： | 1 |
| 8 | HMG - CoA reductase inhibitors reduce MMP - 9 Secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，： | 1 |
| 9 | Soybean protein-diet increases low-density-lipoprotein receptor activity in mononuclear-cells from hypercholesterolemic patients 显示文摘 | Lovati M R Manzoni C Canavesi A | 1987 | Journal of Clinical Investigation1987，80，5： | 1 |
| 10 | HMG-CoA recuctase inhibitors reduce MMP-9 secretionby macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，11： | 1 |
| 11 | Intensive care for pediatric traumatic brain injury显示文摘 | Sigurtà A Zanaboni C Canavesi K | | 0，，01： | 1 |
| 12 | HMG- CoA reductase inhibitors reduce MMP- 9 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vase Biol1998，18，11： | 1 |
| 13 | Relationship between somatic cell count and functional longevity assessed using survival analysis in Italian Holstein-Friesian cows显示文摘 | Samore A B Schneider M del P Canavesi F | | 0，，： | 1 |
| 14 | HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，11： | 1 |
| 15 | In vitro inhibitory effect of lercanidipine on cholesterol accumulation and matrix metallopro- teinases secretion by macrophages 显示文摘 | Canavesi M Baldini N Leonardi A | 2004 | Cardiovasc Pharmacol2004，44，4： | 1 |
| 16 | HMG-CoA Reductase Inhibitors Reduce MMP-9 Secretion by Macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，11： | 1 |
| 17 | HMG-CoA reductase inhibitors reduce MMP-9 Secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，11： | 1 |
| 18 | HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，： | 1 |
| 19 | Rotating savings and credit associations in Boliva显示文摘 | Adams D W Canavesi M L C | 1989 | Savings and Develop- ment1989，13，3： | 1 |
| 20 | Cerebral oxygen consumption and ischemia in traumatic brain injury显示文摘 | Stocchetti N Roncati Zanier E Canavesi K Magnoni S Protti A Longhi L | 2004 | Minerva Anest- esiol2004，70，： | 1 |
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