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1篇 您的检索式:作者名="Candia M.Kenific"
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1An exosome pathway without an ESCRT显示文摘Exosome biogenesis occurs via multiple mechanisms,but how these pathways are controlled remains poorly understood.In a recent study published in Cell Research,Wei et al.identify Rab31 GTPase as a regulator of lipid-mediated exosome biogenesis independent of other commonly-recognized ESCRT and tetraspanin pathways.Exosomes are 30-150 nm vesicles that mediate intercellular crosstalk by transferring bioactive cargos in normal physiology and disease.Exosomes originate in the multivesicular body(MVB)of endosomes;inward membrane budding produces intraluminal vesicles(ILVs)contained within MVBs that carry membrane cargos and molecules from the surrounding cytoplasm.MVBs fuse with the plasma membrane,secreting ILVs as exosomes(Fig.1).Candia M.Kenific Haiying Zhang David Lyden 2021Cell Research2021,31,2:3
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