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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Uncovering individual and collective human dynamics from mobile phone records显示文摘 | CANDIA J GONZALEZ M C WANG P | 2008 | Journal of Physics A: Mathematical and Theoretical2008，41，22： | 1 |
| 3 | Uncovering individual and collective human dynamics from mobile phone records显示文摘 | Candia J Gonzalez M C Wang P | 2008 | Journal of Physics A:Mathematical andTheoretical2008，41，22： | 1 |
| 4 | Management of large pituitary adenomas by transsphenoidal surgery 显示文摘 | BLACK P M ZERVAS N T CANDIA G L | 1988 | Surger Neurol1988，29，6： | 1 |
| 5 | Uncovering individual and collective human dynamics from mobile phone records显示文摘 | CANDIA J GONZALAZ M C WANG P | 2008 | Journal of Physics A: Mathematical and Theoretical2008，41，22： | 1 |
| 6 | Incidence and management of complications of transsphenoidal operation for pituitary adenomas 显示文摘 | BLACK P M ZERVAS N T CANDIA G L | 1987 | Nerosurgery1987，20，6： | 1 |
| 7 | Incidence and management of complications of transsphenoidal operation for pituitary adenomas 显示文摘 | BLACK P M ZERVAS N T CANDIA G L | 1987 | Nerosurgery1987，20，6： | 1 |
| 8 | Effective treatment of refractory pulmonary hemorrhage with monoclonal anti-CD20 antibody (rituximab)显示文摘 | Pinto LF Candia L Garcia P | | 0，，01： | 1 |
| 9 | Effective treatment of refractory pulmonary hemorrhage with monoclonal anti-CD20 antibody(ritux- imab) 显示文摘 | Pinto LF Candia L Garcia P | 2009 | Respiration2009，78，1： | 1 |
| 10 | Cryptorchidism:incidence,risk factors,and potential role of environment;an update显示文摘 | Thonneau PE Candia P Mieusset R | 2003 | J Androl2003，24，2： | 1 |
| 11 | All-trans (PFs),: A Red- ox-Active 2 Donor / 1 Acceptor System Based on the Electrophilic(RuNO) Motif 显示文摘 | De Candia A G Singh P Kaim W | 2009 | Inorg Chem2009，48，56： | 1 |
| 12 | Effective treatment of refractory pulmonary hemorrhage with Monoclonal anti-CD20antibody(rituximab)显示文摘 | Pinto LF Candia L Garcia P | 2009 | Respiration2009，78，1： | 1 |
| 13 | Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and genes related to mitochondrial activity显示文摘 | Blanc SL Villarroel P Candia V | 2012 | Biometals2012，25，4： | 1 |
| 14 | Uncovering individual and collective human dynamics from mobile phone records显示文摘 | Candia J Gonzdlez M C Wang P | 2008 | Journal of Physics A: Mathematical and Theoretical2008，41，22： | 1 |
| 15 | A role for Id proteins in mammary gland physiology and turnorigenesis显示文摘 | De Candia P Benera R Solit D B | 2004 | Adv Cancer Res2004，92，： | 1 |
| 16 | Id4 messenger RNA and estrogen receptor expression: inverse correlation in human normal breast epithelium and carcinoma 显示文摘 | de Candia P Akram M Benezra R | 2006 | Hum Pathol2006，37，8： | 1 |
| 17 | Larval development and metamorphosis in the sea urchin Loxechinus albus ( Echinodermata: Echinoidea) : Effects of diet type and feeding frequency 显示文摘 | CARCAMO P F CANDIA A I CHAPARRO O R | 2005 | Aquaculture2005，249，： | 1 |
| 18 | Selec-tion and use of autochthonous multiplestrain culturesfor the manufacture of high-moisture traditional Moz-zarella cheese 显示文摘 | De Angelis M de Candia S Calasso M P? | 2008 | Int J Food2008，125，： | 1 |
| 19 | Uncovering individual and collective human dynamics from mobile phone records显示文摘 | CANDIA J GONZáLEZ M C WANG P | 2008 | Journal of Physics A:Mathematical and Theoretical2008，41，22： | 1 |
| 20 | The beta-arnyloid pre- cursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation显示文摘 | Minopoli G de Candia P Bonetti A | 2001 | J Biol Chem2001，276，9： | 1 |
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