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	题名	作者	年代	出处	被引量
1	Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles显示文摘The spread of coronavirus disease 2019(COVID-19)throughout the world has resulted in stressful healthcare burdens and global health crises.Developing an effective measure to protect people from infection is an urgent need.The blockage of interaction between angiotensin-converting enzyme 2(ACE2)and S protein is considered an essential target for anti-severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)drugs.A full-length ACE2 protein could be a potential drug to block early entry of SARS-Co V-2 into host cells.In this study,a therapeutic strategy was developed by using extracellular vesicles(EVs)with decoy receptor ACE2 for neutralization of SARS-Co V-2.The EVs embedded with engineered ACE2(EVs-ACE2)were prepared;the EVs-ACE2 were derived from an engineered cell line with stable ACE2 expression.The potential effect of the EVs-ACE2 on anti-SARS-Co V-2 was demonstrated by both in vitro and in vivo neutralization experiments using the pseudovirus with the S protein(S-pseudovirus).EVs-ACE2 can inhibit the infection of S-pseudovirus in various cells,and importantly,the mice treated with intranasal administration of EVs-ACE2 can suppress the entry of S-pseudovirus into the mucosal epithelium.Therefore,the intranasal EVs-ACE2 could be a preventive medicine to protect from SARS-Co V-2 infection.This EVs-based strategy offers a potential route to COVID-19 drug development.	Canhao Wu Qin Xu Huiyuan Wang Bin Tu Jiaxin Zeng Pengfei Zhao Mingjie Shi Hong Qiu Yongzhuo Huang	2022	Acta Pharmaceutica Sinica B2022，12，3：	2
2	Remote intracerebral hematoma after rt-PA in acute stroke显示文摘	Falcao F Canhao P Melo T	2008	Cerebrovasc Dis2008，25，2：	1
3	Lumbar puncture and dural sinusthrombosis-a causal or casual association?显示文摘	Canhao P Batista P Falcao F	2005	Cerebrovasc Dis2005，19，1：	1
4	Systemic thrombolysis for cerebral venous and dural sinus thrombosis: a systematic review显示文摘	Viegas LD Stolz E Canhao P	2014	Cerebrovasc Dis2014，37，1：	1
5	Early vascular alterations in SLE and RA patients-a step towards understanding the associated cardiovascular risk 显示文摘	Santos MJ Carmona-Fernandes D Canhao H	2012	PLoS One2012，7，44：	1
6	Intemationnal study on cerebral vein and dural sinus thrombosis显示文摘	Canhao P Barinagarrementeria F Bousser MG	2001	Cerebrovascular diseases2001，15，4：	1
7	Atraumatie localized convexity subarachnoid hemorrhage associated with acute carotid artery occtusion显示文摘	Geraldes R Santos C Canhao P	2011	Eur J Neurol2011，18，2：	1
8	Thrombolytics for Cerebral Sinus Thrombosis 显示文摘	Canhao P Falcao F Ferro JM	2003	Cerebrovascular diseases2003，15，2：	1
9	Osteoblasts and bone formation 显示文摘	Caetano Lopes J Canhao H Fonseca JE	2007	Acta Reumatol Port2007，32，2：	1
10	Prognosis of cerebral vein and dural sinus thrombosis:results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) 显示文摘	Ferro JM Canhao P Stam J	2004	Stroke2004，35，3：	1
11	Prognosis of cerebral vein and dural sinus thrombosis:results of the International Study on Cerebral Vein and Dural Sinus Thrombosis ( ISCVT)显示文摘	Ferro JM Canhao P Stam J	2004	Stroke2004，35，：	1
12	Atraumatic localized convexity subarachnoid hemorrhage associated with acute carotid artery occlusion显示文摘	Geraldes R Santos C Canhao P	2011	Eur J Neurol2011，18，：	1
13	Acute treatment of cerebral venous and dural sinus thrombosis显示文摘	Ferro JM Canhao P	2008	Curr Treat Options Neurol2008，10，2：	1
14	Vascular risk factors for perimesencephalic nonaneurysmal subarachnoid hemorrhage显示文摘	Canhao P Faleao F Pinto e Melo T	1999	J Neurol1999，246，：	1
15	Prognosis of cerebral vein and dural sinus thrombosis:results of the International Study on Cerebral Vein and Dural Sinus Thrombosis(ISCVT)显示文摘	Ferro JM Canhao P Stam J	2004	Stroke2004，35，3：	1
16	Unfractionatedor low~mo-lecular weight heparin for the treatment of cere ~bral venous throm-bosis显示文摘	Coutinho JM Ferro JM Canhao P		0，，11：	1
17	Atraumatic localized convexity sub- arachnoid hemorrhage associated with acute carotid artery occlusion ' 显示文摘	Geraldes R Santos C Canhao P	2011	Eur J Neurol2011，18，2：	1
18	Seizures at the onset of subaraclmoid haemorrhage 显示文摘	Pinto AN Canhao P Ferro JM	1996	J Neurol1996，243，2：	1
19	Prognosis of cerebral vein and duralsinus thrombosis:results of the international study on cerebral vein and dural sinus thrombosis (ISCVT)显示文摘	Ferro J M Canhao P Stam J	2004	Stroke2004，35，3：	1
20	Thrombolytics for cerebral sinus thrombosis: a systematic review 显示文摘	Canhao P Falcao F Ferro JM	2003	Cerebrovasc Dis2003，15，3：	1

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