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| 1 | Radiomics in colorectal cancer patients显示文摘The main therapeutic options for colorectal cancer are surgical resection and adjuvant chemotherapy in non-metastatic disease.However,the evaluation of the overall adjuvant chemotherapy benefit in patients with a high risk of recurrence is challenging.Radiological images can represent a source of data that can be analyzed by using automated computer-based techniques,working on numerical information coded within Digital Imaging and Communications in Medicine files:This image numerical analysis has been named“radiomics”.Radiomics allows the extraction of quantitative features from radiological images,mainly invisible to the naked eye,that can be further analyzed by artificial intelligence algorithms.Radiomics is expanding in oncology to either understand tumor biology or for the development of imaging biomarkers for diagnosis,staging,and prognosis,prediction of treatment response and diseases monitoring and surveillance.Several efforts have been made to develop radiomics signatures for colorectal cancer patient using computed tomography(CT)images with different aims:The preoperative prediction of lymph node metastasis,detecting BRAF and RAS gene mutations.Moreover,the use of delta-radiomics allows the analysis of variations of the radiomics parameters extracted from CT scans performed at different timepoints.Most published studies concerning radiomics and magnetic resonance imaging(MRI)mainly focused on the response of advanced tumors that under-went neoadjuvant therapy.Nodes status is the main determinant of adjuvant chemotherapy.Therefore,several radiomics model based on MRI,especially on T2-weighted images and ADC maps,for the preoperative prediction of nodes metastasis in rectal cancer has been developed.Current studies mostly focused on the applications of radiomics in positron emission tomogra-phy/CT for the prediction of survival after curative surgical resection and assessment of response following neoadjuvant chemoradiotherapy.Since colorectal liver metastases develop in about 25%of patients with colorectal carcinoma,the main diagnostic tasks of radiomics should be the detection of synchronous and metachronous lesions.Radiomics could be an additional tool in clinical setting,especially in identifying patients with high-risk disease.Nevertheless,radiomics has numerous shortcomings that make daily use extremely difficult.Further studies are needed to assess performance of radiomics in stratifying patients with high-risk disease. | Riccardo Inchingolo Cesare Maino Roberto Cannella Federica Vernuccio Francesco Cortese Michele Dezio Antonio Rosario Pisani Teresa Giandola Marco Gatti Valentina Giannini Davide Ippolito Riccardo Faletti | 2023 | World Journal of Gastroenterology2023，29，19： | 4 |
| 2 | Hydrogen breath test for the diagnosis of lactose intolerance,is the routine sugar load the best one?显示文摘AIM: To evaluate the prevalence of lactose intolerance (LI) following a load of 12.5 g in patients diagnosed as high-grade malabsorbers using the hydrogen breath test (HBT)-25.METHODS: Ninety patients showing high-grade malabsorption at HBT-25 were submitted to a second HBT with a lactose load of 12.5 g.Peak hydrogen production,area under the curve of hydrogen excretion and occurrence of symptoms were recorded.RESULTS: Only 16 patients (17.77%) with positive HBT-25 proved positive at HBT-12.5.Hydrogen production was lower as compared to HBT-25 (peak value 21.55 parts per million (ppm) ± 29.54 SD vs 99.43 ppm ± 40.01 SD; P < 0.001).Symptoms were present in only 13 patients.The absence of symptoms during the high-dose test has a high negative predictive value (0.84) for a negative low-dose test.The presence of symptoms during the first test was not useful for predicting a positive low-dose test (positive predictive value 0.06-0.31).CONCLUSION: Most patients with a positive HBT-25 normally absorb a lower dose of lactose and a strict lactose restriction on the basis of a 'standard' HBT is,in most instances,unnecessary.Thus,the 25 g lactose tolerance test should probably be substituted by the 12.5 g test in the diagnosis of LI,and in providing dietary guidelines to patients with suspected lactose malabsorption/intolerance. | Fiorenza Argnani Mauro Di Camillo Vanessa Marinaro Tiziana Foglietta Veronica Avallone Carlo Cannella Piero Vernia | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 3 | Impacts of the COVID-19 pandemic on the dairy industry: Lessons from China and the United States and policy implications显示文摘The purposes of this study are to assess the COVID-19 pandemic’s impacts on the dairy industries in China and the United States and to derive policy recommendations for enhancing the diary industries’resilience to pandemics and other market shocks.Specifically,data from the two nations are used to analyze and compare the mechanisms through which the pandemic has affected their dairy industries and to discuss potential lessons from their experiences.The findings suggest that this pandemic has heavily affected the dairy industries in both China and the United States through similar mechanisms,such as decreased farmgate milk prices,disruption and difficulties of moving milk within the supply chains,worker shortages,increased production costs,and lack of operating capital.There were also significant differences in the affecting mechanisms between the two nations,including transportation difficulties from widespread road closures and significant reduction in holiday sales of dairy products in China,and the shutdown of many dairy processors in the United States due to the closing of schools,restaurants,and hotels.While government financial reliefs are highly needed to help many dairy farms and processors survive this pandemic in the short term,the dairy industries and governments need to work together to develop long-term strategies and policies to balance the industries’efficiency and flexibility,product specialization and diversification,supply chain integration and local food systems,and market mechanisms and policy regulations and interventions. | Qingbin WANG LIU Chang-quan ZHAO Yuan-feng Anthony KITSOS Mark CANNELLA WANG Shu-kun HAN Lei | 2020 | Journal of Integrative Agriculture2020，19，12： | 3 |
| 4 | New advances in radiomics of gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs)are uncommon neoplasms of the gastrointestinal tract with peculiar clinical,genetic,and imaging characteristics.Preoperative knowledge of risk stratification and mutational status is crucial to guide the appropriate patients’treatment.Predicting the clinical behavior and biological aggressiveness of GISTs based on conventional computed tomography(CT)and magnetic resonance imaging(MRI)evaluation is challenging,unless the lesions have already metastasized at the time of diagnosis.Radiomics is emerging as a promising tool for the quantification of lesion heterogeneity on radiological images,extracting additional data that cannot be assessed by visual analysis.Radiomics applications have been explored for the differential diagnosis of GISTs from other gastrointestinal neoplasms,risk stratification and prediction of prognosis after surgical resection,and evaluation of mutational status in GISTs.The published researches on GISTs radiomics have obtained excellent performance of derived radiomics models on CT and MRI.However,lack of standardization and differences in study methodology challenge the application of radiomics in clinical practice.The purpose of this review is to describe the new advances of radiomics applied to CT and MRI for the evaluation of gastrointestinal stromal tumors,discuss the potential clinical applications that may impact patients’management,report limitations of current radiomics studies,and future directions. | Roberto Cannella Ludovico La Grutta Massimo Midiri Tommaso Vincenzo Bartolotta | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 5 | Are family firms really superior performers?显示文摘 | Danny Miller Isabelle Le Breton-Miller Richard H. Lester Albert A. Cannella | 2007 | Journal of Corporate Finance2007，，5： | 3 |
| 6 | Evaluation of posttreatment response of hepatocellular carcinoma: comparison of ultrasonography with second-generation ultrasound contrast agent and multidetector CT显示文摘 | Giuseppe Salvaggio Antonella Campisi Vito Greco Isidoro Cannella Maria Franca Meloni Giuseppe Caruso | 2010 | Abdominal Imaging2010，，4： | 2 |
| 7 | Liver metastases:The role of magnetic resonance imaging显示文摘The liver is one of the organs most commonly involved in metastatic disease,especially due to its unique vascularization.It’s well known that liver metastases represent the most common hepatic malignant tumors.From a practical point of view,it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients,to select the best treatment possible,and finally to predict the overall prognosis.In the past few years,imaging techniques have gained a central role in identifying liver metastases,thanks to ultrasonography,contrast-enhanced computed tomography(CT),and magnetic resonance imaging(MRI).All these techniques,especially CT and MRI,can be considered the noninvasive reference standard techniques for the assessment of liver involvement by metastases.On the other hand,the liver can be affected by different focal lesions,sometimes benign,and sometimes malignant.On these bases,radiologists should face the differential diagnosis between benign and secondary lesions to correctly allocate patients to the best management.Considering the above-mentioned principles,it’s extremely important to underline and refresh the broad spectrum of liver metastases features that can occur in everyday clinical practice.This review aims to summarize the most common imaging features of liver metastases,with a special focus on typical and atypical appearance,by using MRI. | Cesare Maino Federica Vernuccio Roberto Cannella Francesco Cortese Paolo NiccolòFranco Clara Gaetani Valentina Giannini Riccardo Inchingolo Davide Ippolito Arianna Defeudis Giulia Pilato Davide Tore Riccardo Faletti Marco Gatti | 2023 | World Journal of Gastroenterology2023，29，36： | 2 |
| 8 | Betaine administration corrects ethanol-induced defective VLDL secretion显示文摘 | Kusum K. Kharbanda Sandra L. Todero Brian W. Ward John J. Cannella Dean J. Tuma | 2009 | Molecular and Cellular Biochemistry2009，，： | 2 |
| 9 | Social capital and knowledge creation- diminishing returns of the number and strength of exchange relationships显示文摘 | Ann M M Cannella Jr A A | 2004 | Academy of Management Journal2004，47，： | 1 |
| 10 | Early defect of transforming growth factor betal formation in Huntington' s disease 显示文摘 | Battaglia G Cannella M Riozzi B | 2011 | Journal of Cellular and Molecular Medicine2011，15，3： | 1 |
| 11 | The Role o{ Risk in Executive Compensation显示文摘 | GRAY S R CANNELLA JR A A | 1997 | Journal of Manage- ment1997，23，4： | 1 |
| 12 | Automatic folding of cartons using a reconfigurable robotic system显示文摘 | YAO W CANNELLA F DAI J S | 2011 | Robotics and Computer-lntegrated Manufacturing2011，27，3： | 1 |
| 13 | Novel Munc13-4mutations in children and young adult patients withhaemophagocytic lymphohistiocytosis显示文摘 | Santoro A Cannella S Bossi G | 2006 | J Med Genet2006，43，12： | 1 |
| 14 | 23Na TQF NMR imaging for the study of spinal disc tissue显示文摘 | Ooms KJ Cannella M Vege AJ | 2008 | J Magn Reson2008，195，1： | 1 |
| 15 | Initial public offering investor valuations: an examination of top management team prestige and environmental uncertainty 显示文摘 | Lester R H Certo S T Dalton C M Dalton D R Cannella A A | 2006 | Journal of Small Business Management2006，44，1： | 1 |
| 16 | Desulfurization of transportation fuels with zeolite under ambient conditions 显示文摘 | Yang R T Hemandez-Maldonado A J Cannella W | 2003 | Science2003，301，5629： | 1 |
| 17 | Social Capital and Knowledge Creation: Diminishing Returns of the Number and Strength of Exchange Relationships 显示文摘 | M Ann Mcfadyen Albert A Cannella JR | 2004 | Academy of Manage- ment Journal2004，，5： | 1 |
| 18 | Medication-related Problems in Ambulatory Hemodialysis Patients:a Pooled Analysis显示文摘 | Manley H J Cannella C A Bailie G R | 2005 | Am J Kidney Dis2005，46，4： | 1 |
| 19 | Novel Munc 13-4 mutations in children and young adult patients with haemophagocytic lym- phohistiocytosis 显示文摘 | Santoro A Cannella S Bossi G | 2006 | J Med Genet2006，43，12： | 1 |
| 20 | Social Capital and Knowledge Creation: Diminishing Returns of the Number and Strength of Ex- change 显示文摘 | MCFADYEN M A CANNELLA J A | 2004 | The Academy of Management Journal2004，47，5： | 1 |
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