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您的检索式：作者名="Canwen Chen"
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| 1 | Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing显示文摘A patch with the capability of avoiding wound infection and promoting tissue remolding is of great value for wound healing.In this paper,we develop a biomass chitosan microneedle array(CSMNA)patch integrated with smart responsive drug delivery for promoting wound healing.Chitosan possesses many outstanding features such as the natural antibacterial property and has been widely utilized for wound healing.Besides,the microstructure of microneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the patch.Also,vascular endothelial growth factor(VEGF)is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel.Therefore,the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds.It is demonstrated that the biomass CSMNA patch can promote inflammatory inhibition,collagen deposition,angiogenesis,and tissue regeneration during the wound closure.Thus,this versatile CSMNA patch is potentially valuable for wound healing in clinical applications. | Junjie Chi Xiaoxuan Zhang Canwen Chen Changmin Shao Yuanjin Zhao Yongan Wang | 2020 | Bioactive Materials2020，5，2： | 25 |
| 2 | Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment显示文摘The treatment of diabetic wounds remains a great challenge for medical community.Here,we present a novel structural color supramolecular hydrogel patch for diabetic wound treatment.This hydrogel patch was created by using N-acryloyl glycinamide(NAGA)and 1-vinyl-1,2,4-triazole(VTZ)mixed supramolecular hydrogel as the inverse opal scaffold,and temperature responsive poly(N-isopropylacrylamide)(PNIPAM)hydrogel loaded with vascular endothelial cell growth factor(VEGF)as a filler.Supramolecular hydrogel renders hydrogel patch with superior mechanical properties,in which NAGA and VTZ also provide self-healing and antibacterial properties,respectively.Besides,as the existence of PNIPAM,the hydrogel patch was endowed with thermal-responsiveness property,which could release actives in response to temperature stimulus.Given these excellent performances,we have demonstrated that the supramolecular hydrogel patch could significantly enhance the wound healing process in diabetes rats by downregulating the expression of inflammatory factors,promoting collagen deposition and angiogenesis.Attractively,due to responsive optical property of inverse opal scaffold,the hydrogel patch could display color-sensing behavior that was suitable for the wound monitoring and management as well as guidance of clinical treatment.These distinctive features indicate that the presented hydrogel patches have huge potential values in biomedical fields. | Canwen Chen Yu Wang Han Zhang Hui Zhang Weiliang Dong Weijian Sun Yuanjin Zhao | 2022 | Bioactive Materials2022，7，9： | 2 |
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