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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association显示文摘Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care significantly.We aimed to illustrate how the stroke services were interrupted during the pandemic in China.Methods A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who were involved in treating patients with stroke from 1 February to 31 March 2020.Results A total of 415 respondents completed the online survey after informed consent was obtained.Of the respondents,37.8%,35.2%and 27.0%were from mild,moderate and severe epidemic areas,respectively.Overall,the proportion of severe impact(reduction>50%)on the admission of transient ischaemic stroke,acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)was 45.0%,32.0%and 27.5%,respectively.Those numbers were 36.9%,27.9%and 22.3%;36.5%,22.1%and 22.6%;and 66.4%,47.5%and 41.1%in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For AIS,thrombolysis was moderate(20%-50%reduction)or severely impacted(>50%),as reported by 54.4%of the respondents,while thrombectomy was 39.3%.These were 44.4%,26.3%;44.2%,39.4%;and 78.2%,56.5%,in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For patients with acute ICH,39.8%reported the impact was severe or moderate for those eligible for surgery who had surgery.Those numbers were 27.4%,39.0%and 58.1%in mild,moderate and severe epidemic areas,respectively.For staff resources,about 20%(overall)to 55%(severe epidemic)of the respondents reported moderate or severe impact on the on-duty doctors and nurses.Conclusion We found a significant reduction of admission for all types of patients with stroke during the pandemic.Patients were less likely to receive appropriate care,for example,thrombolysis/thrombectomy,after being admitted to the hospital.Stroke service in severe COVID-19 epidemic areas,for example,Wuhan,was much more severely impacted compared with other regions in China. | Xia Wang Menglu Ouyang Cheryl Carcel Chen Chen Lingli Sun Jie Yang Yao Zhang Guofang Chen Shoujiang You Yongjun Cao Lu Ma Xin Hu Yi Sui Craig Anderson Lili Song Yongjun Wang David Wang | 2020 | Stroke & Vascular Neurology2020，5，4： | 2 |
| 3 | Size characterisation of glutenin polymers by HPS显示文摘 | Carceller J L Aussenac T | 2001 | Journal of Cereal Science2001，33，： | 2 |
| 4 | Dilared and contracted forms of primary endocardial fibroelastosis:a single fetal disease with two stages of development显示文摘 | CARCELLER A M MAROTO E FOURON J C | 1990 | Br Heart J1990，63，5： | 1 |
| 5 | Oculographicfindings in 145 patients with benign paroxysmal positional vertigo显示文摘 | Domenech Campos E Armen Got Carcell ER M Barona DE | 2006 | Acta Otorrinola ringol Esp2006，57，： | 1 |
| 6 | Pharmacokinetic sofamoxicillin clavulanicacid combination andof both drugs alone after intravenous administ ration to goats显示文摘 | Escudero E Carceles CM Vicente S | 1996 | Br Vet J1996，152，5： | 1 |
| 7 | Intravenous fibroblast growth factor penetrates the blood-brain barrier and protects hippocampal neurons against ischemia reperfusion injury显示文摘 | GUEVAS P CARCELLER F MUNOZ-WILLERY L | 1998 | Surg Neurol1998，49，1： | 1 |
| 8 | Milk kinetics of moxidectin and DRMamectin in goatst 显示文摘 | Carceles C M Diaz M S | 2001 | Research in veterinary Science2001，70，3： | 1 |
| 9 | Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at lp and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component 显示文摘 | Torres-Martin M Pena-Granero C Carceller F | 2014 | Mol Cytogen- et2014，7，1： | 1 |
| 10 | The intraluminal thread model revisited :rat strain differences in local cerebral blood flow显示文摘 | Prieto R Carceller F Roda JM | 2005 | Neural Res2005，27，1： | 1 |
| 11 | Size characterization of glutenin polymers by HPSEC-MALLS显示文摘 | CARCELLER J L AUSSENAC T | 2001 | Journal of Cereal Science2001，33，： | 1 |
| 12 | Fibroblast growth factors and cerebral ischemia 显示文摘 | Cuevas P Carceller F Gimenez G | 1994 | Neurol Res1994，16，： | 1 |
| 13 | Peripheral nerve regeneration by bone marrow stromal cells显示文摘 | Cuevas P Carceller F Dujovny M | 2002 | Neurol Res2002，24，7： | 1 |
| 14 | Single-dose pharma cokinetics of ampicillin/sulbactam (2 : 1) combination after in travenous administration to sheep and goats显示文摘 | Carceles C M Espuny A Vicente M S | 1996 | Research in Vet erinary Science1996，61，： | 1 |
| 15 | Dilated and contracted forms of pri mary endocardial fibroelastosis:A single fetal disease with two stages of development 显示文摘 | Carceller AM Maroto E Fouron JC | 1990 | Br Heart J1990，63，5： | 1 |
| 16 | Fibroblast growth factor and cerebral edema显示文摘 | Cuevas P Carceller F Gimenez GG | 1994 | Neurol Res1994，16，3： | 1 |
| 17 | The intraluminal thread model revisited:Rat strain differences in local cerebral blood flow显示文摘 | Prieto R Carceller F Roda JM | 2005 | Neurol Res2005，27，： | 1 |
| 18 | Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia 显示文摘 | Sobrado M Lopez MG Carceller F | 2003 | Neurscience2003，118，1： | 1 |
| 19 | Milk kinetics of moxidectin and doramectin in goats显示文摘 | Carceles C M Diaz M S | 2001 | Research in Veterinary Science2001，70，3： | 1 |
| 20 | The intraluminal thread model revisited:rat stain differences in local cerebral blood flow显示文摘 | Carceller F Roda JM | 2005 | Neurol Res2005，27，1： | 1 |
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