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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | High pressure X-ray investigations on 3C-SiC 显示文摘 | Strossner K Cardona M Choyke W J | 1987 | Solid State Commun1987，63，2： | 1 |
| 3 | Surface textures of heavy-mineral grainst a new contribution to provenance studies显示文摘 | Cardona J P M Gutie'rrez Mas J M Bello'n A S | 2005 | Sedimentary Geology2005，174，： | 1 |
| 4 | Infrared and Raman spectra of the Silicon-hydrogen bonds in amor- phous silicon prepared by glow discharge and sputter- ing显示文摘 | Brodsky M H Cardona M Cuomo J J | 1977 | Phys Rev B1977，16，： | 1 |
| 5 | Role of repeat staging laparos- copy in locoregion',flly advanced gastric or gastroesophageal cancer after neoadjuvant therapy显示文摘 | Cardona K Zhou Q Shah M A | 2013 | Annals of surgical oncology2013，20，54： | 1 |
| 6 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 7 | ICT and productivity: conclusions from the empirical literature 显示文摘 | Cardona M Kretsehmer T Strobel T | 2013 | Information Economics and Policy2013，25，3： | 1 |
| 8 | Photoactivation of metal oxide surfaces:photocatalyzed oxidation of alcohols by heteropolytungstates显示文摘 | Fox M A Cardona R Gaillard E | 1987 | J Am Chem Soc1987，109，21： | 1 |
| 9 | Petri nets and genetic algorithms for complex manufacturing systems scheduling显示文摘 | Gonzalo M Carlos M Cardona J | 2012 | International Journal of Production Research2012，50，3： | 1 |
| 10 | Quasipar- ticle self-consistent GW calculations for PbS, PbSe, and PbTe: Band structure and pressure coefficients 显示文摘 | Svane A Christensen N E Cardona M | 2010 | Physical Review B2010，81，24： | 1 |
| 11 | 显示文摘 | Schmidt R L McCombe B D Cardona M | 1975 | Physical Review B1975，11，2： | 1 |
| 12 | Geological and en- vironmental implications of the evaporite karst in Spain 显示文摘 | Gutierrez F Calaforra J M Cardona F | 2008 | En- vironmental Geology2008，53，5： | 1 |
| 13 | Leiomyoma of the urinary bladder: a case report显示文摘 | Ortiz M Henao DE Cardona MW | 2013 | Im Braz J Uro12013，39，： | 1 |
| 14 | Infrared and Raman spectra of the silicon-hydrogen bonds in amorphous silicon prepared by glow discharge and sputtering显示文摘 | BRODSKY M H CARDONA M CUOMO J J | 1977 | Phys Rev B1977，16，： | 1 |
| 15 | Effect of uniaxial stress on the zone-center optical phonon of diamond显示文摘 | Grimsditch M H Anastassakis E Cardona M | 1978 | Phys Rev B1978，18，2： | 1 |
| 16 | Optical Properties and Band Structure of Wurtzite-Type Crystals and Rutile 显示文摘 | Cardona M Harbeke G | 1965 | Physical Review1965，137，5： | 1 |
| 17 | Control of microglial neurotoxicity by the fractalkine receptor 显示文摘 | Cardona A E Pioro E P Sasse M E | 2006 | Nat Nenrosci2006，9，7： | 1 |
| 18 | Urban seismic risk evaluation: A holistic approach显示文摘 | Carreno M L Cardona 0 D Barbat A H | 2007 | Natural Hazards2007，40，1： | 1 |
| 19 | 显示文摘 | Gofii A R Syassen K Cardona M | 1990 | Phys Rev B1990，41，10： | 1 |
| 20 | Surface textures of heavy-mineral grains:a new contribution to provenance studies显示文摘 | CARDONA J P M GUTIECRREZ Mas J M BELLOCN A S | 2005 | Sedimentary Geology2005，174，： | 1 |
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