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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Functional properties of anthocyanins and betalains in plants, food, and in human nutrition 显示文摘 | Stintzing F C Carle R | 2004 | Trends Food Sci Technol2004，15，： | 1 |
| 3 | Functional properities of antho- cyanins and betalains in plants, food,and in human nutrition 显示文摘 | STINGZING F C CARLE R | 2004 | Trends in Food Science and Technology2004，15，3： | 1 |
| 4 | Quality and authenticity control of fruit purées,fruit preparations and jams:a review显示文摘 | F(U)GEL R CARLE R SCHIEBER A | 2005 | Trends in Food Science & Technology2005，16，： | 1 |
| 5 | Functional properties of anthoeyanins and betalins in plants, food, and in human nutrition 显示文摘 | Stintzing F C Carle R | 2004 | Trends in Food Science & Technology2004，15，： | 1 |
| 6 | Strong oxide-oxide interaction in silicasupported magnetite catalysts 显示文摘 | Carl R F Dumesic J A | 1981 | Phys Chem1981，85，21： | 1 |
| 7 | By- products of plant food processing as a source of functional compounds recent developments显示文摘 | SCHIEBER A STINTZING F C CARLE R | 2001 | Trends Food Sci Tech2001，12，11： | 1 |
| 8 | Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL显示文摘 | Weerapan Khovidhunkit Philippe N Duchateau Katalin F Medzihradszky Arthur H Moser Josefina Naya-Vigne Judy K Shigenaga John P Kane Carl Grunfeld Kenneth R Feingold | 2004 | Atherosclerosis2004，，1： | 1 |
| 9 | Do anthropo- metric and fitness characteristics vary according to birth date distribution in elite youth academy soccer players? 显示文摘 | CARLING C LE GALL F R REILLY T | 2009 | Scand J Med Sci Sports2009，，19： | 1 |
| 10 | Thermal degradation of acylated and nonacylated anthocyanins 显示文摘 | Sadilova E Stintzing F C Carle R | 2006 | Journal of Food Science2006，71，8： | 1 |
| 11 | Color and antioxidant properties of cyaniding-based anthocyanin pigments显示文摘 | STINTZING F STINTZING N CARLE R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 12 | Functional properties of anthocyanins and betalains in plants, food, and in human nutrition 显示文摘 | Stintzing F C Carle R | 2004 | Trends in Food Science & Technology2004，15，1： | 1 |
| 13 | Thermal degradation of acylated and nonacylated anthocyanins显示文摘 | Sadilova E Stintzing F C Carle R | 2006 | Journal of Food Science2006，71，8： | 1 |
| 14 | Functional properties of anthocyaninsand betalains in plants, food, and in human nutrition显示文摘 | STINTING F C CARLE R | 2004 | Trends in Food Science and Technology2004，15，1： | 1 |
| 15 | By-products of plant food processing as a source of functional compounds-recent developments显示文摘 | Schieber A Stintzing F C Carle R | | 0，，： | 1 |
| 16 | Betacyanins in fruits from red-purple pitaya: Hylocereus polyrhizus (Weber) Britton & Rose显示文摘 | STINTZ1NO F C SCHIEBER A CARLE R | 2002 | Food Chem2002，77，1： | 1 |
| 17 | Thermal degradation of acylated and nonacylated anthocyanins显示文摘 | SADILOVA E ST1NTZING F C CARLE R | 2006 | Food Chemistry and Toxicology2006，71，8： | 1 |
| 18 | Exercise induced myocardial ischemia detected by cardiopulmonary exercise testing显示文摘 | Belardinelli R Lacalaprice F Carle F | | 0，，： | 1 |
| 19 | Rapid flash annealing of thermally reactive copolymers in a roll-to-roll process for polymer solar cells显示文摘 | Helgesen M Carle J E Andreasen B Hosel M NorrmanK Sondergaard R Krebs F C | 2012 | Polymer Chemistry2012，3，9： | 1 |
| 20 | Betalain stability and deg- radation- Structural and chromatic aspects 显示文摘 | Herbach K M Stintzing F C Carle R | 2006 | JOURNAL OF FOOD SCIENCE2006，71，4： | 1 |
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