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| 1 | 肾髓质癌中SMARCB1蛋白表达缺失的独特机制:20例形态学和分子分析显示文摘肾髓质癌是一种罕见但极具侵袭性的肾癌,其发生在具有镰状红细胞病或罕见具有其他血红蛋白病的患者。SMARCB1是SWI/SNF染色质重塑复合物的核心亚基,该蛋白表达缺失是肾髓质癌的主要诊断特征。然而,SMARCB1蛋白表达缺失的分子机制尚不清楚。作者回顾性分析了两家机构于1996~2017年期间诊断的20例肾髓质癌。所有患者均有镰状红细胞病,所有肿瘤免疫组化显示有SMARCB1蛋白表达缺失。用3色探针荧光原位杂交(FISH)检测SMARCB1位点状态,并用靶向二代测序平台检测SMARCB1在体细胞内结构的变化情况。20例患者的FISH分析显示,11例(55%)同时存在半合子缺失和SMARCB1易位,6例(30%)SMARCB1纯合子缺失,3例(15%)虽然有SMARCB1蛋白缺失却无结构或拷贝数的改变。 | 魏建国(摘译) 袁晓露(审校) Jia L Carlo M I Khan H | 2019 | 临床与实验病理学杂志2019，35，8： | 3 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Regional scale variation in forest structure and biomass in the Yucatan Peninsula, Mexico: Effects of forest disturbance 显示文摘 | TANIA U H PAUL M D CARLOS A P | 2007 | Forest Ecol Management2007，247，： | 1 |
| 4 | An Exploratory Study of Environmental Attitudes and the Willingness to Pay for Environmental Certi- fication in Mexico 显示文摘 | Bryan W H Michael V R Carlos E B M etal | 2014 | Business Research2014，67，5： | 1 |
| 5 | Petrophysical inversion of borehole arry-inductionlogs:Part Ⅰ-Numerical examples显示文摘 | Faruk O A Carlos T-V Tarek M H | 2006 | Geophysics2006，71，4： | 1 |
| 6 | Vohammetric and morphological characterization of copper electrodeposition from non - cyanide electrolyte 显示文摘 | De Almeida M R H Carlos I A Barbosa L L | 2002 | Journal of Applied Electrochemistry2002，32，： | 1 |
| 7 | The effects of 1,25-Dihydroxycholecalciferol and phytase on the natural phytase phosphorus utilization by hying hens 显示文摘 | Carlos A B Edwards H M | 1998 | Poultry Science1998，77，： | 1 |
| 8 | Corona destruction: An innovative control technology for VOCS and air toxies 显示文摘 | Carlos M Nunez Geddes H Ramsey Wade H Ponder | 1993 | Air & Waste Management Association1993，，43： | 1 |
| 9 | A combined electrocoagulation-sorption process applied to mixed industrial wastewater显示文摘 | Ivonne L H CARLOS B D GABTIELA R M | 2007 | Journal of Hazardous Materials2007，144，12： | 1 |
| 10 | Double versus single renal allografts from agel donors 显示文摘 | Amado A jose mara M Juan Carlos H | 2000 | Transplantation2000，69，10： | 1 |
| 11 | Eye gaze tracking techniques for interactive applications 显示文摘 | Morimoto Carlos H Mimica Marcio R M | 2005 | Computer Vision and Image Understanding2005，98，1： | 1 |
| 12 | Nickel metal hydride batteries for high power applications 显示文摘 | LUISA S M JOAQUIN C J CARLOS H | 2001 | Joumal of Power Sources2001，96，： | 1 |
| 13 | Treatment with hydroxyurea in thalassernia intermedia with paravertebral pseudo tumors of extramedullary hernatopoiesis 显示文摘 | Carlo H Wegener M Debatin K | 2002 | Am Hernatol2002，81，8： | 1 |
| 14 | Rare earth element geochemistry of seamount ferromanganese deposits from the Hawaii Archipelago显示文摘 | De Carlo E H Mcmurtry G M | 1992 | Chemical Geology1992，95，： | 1 |
| 15 | Group 6 metal oxide carbon aerogels: Their syn- thesis, characterization and catalytic activity in the skeletal isomerization of 1 butene显示文摘 | CARLOS M C JOSE F M H JOSE R U | 1999 | Appl Catal A: General1999，183，： | 1 |
| 16 | Cancer control in the A- sia Pacific region: current status and concerns显示文摘 | Shin H R Carlos M C Varghese C | 2012 | Jpn J Clin Oncol2012，42，10： | 1 |
| 17 | Disaster-survivable cloud-network mapping 显示文摘 | Carlos Colman-Meixner Ferhat Dikbiyik M Farhan H abib | 2014 | Photonic network communications2014，27，3： | 1 |
| 18 | Expression and enzymatic activity of phenylalanine ammonia - lyase and p - coumarate 3 - hydroxylase in mango (Mangifera indica 7taulfo) during ripening显示文摘 | Palafox - Carlos H Contreras - Vergara CA Muhlia - Almaz(m A | 2014 | C enet Mol Res2014，13，2： | 1 |
| 19 | Voltammetric and morphological characterization of copper electrodeposition from non-cyanide electrolyte显示文摘 | De Almeida M R H Carlos I A Barbosa L L | 2002 | Journal of Applied Electrochemistry2002，32，7： | 1 |
| 20 | Study and development of an alkaline bath for copper deposition containing sorbitol as complexing agent and morphological characterization of the copper film显示文摘 | Barbosa L L de Almeida M R H Carlos R M | 2005 | Surface & Coatings Technology2005，192，23： | 1 |
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