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| 1 | Current concepts in total femoral replacement显示文摘Total femoral replacement(TFR) is a salvage arthroplasty procedure used as an alternative to lower limb amputation. Since its initial description in the mid-20^(th) century, this procedure has been used in a variety of oncologic and non-oncologic indications. The most compelling advantage of TFR is the achievement of immediate fixation which permits early mobilization. It is anticipated that TFR will be increasingly performed as the rate of revision arthroplasty rises worldwide. The existing literature is mainly composed of a rather heterogeneous mix of retrospective case series and a wide assortment of case reports. Numerous TFR prostheses are currently available and the surgeon must understand the unique implications of each implant design. Long-term functional outcomes are dependent on adherence to proper technique and an appropriate physical therapy program for postoperative rehabilitation. Revision TFR is mainly performed for periprosthetic infection and the severe femoral bone loss associated with aseptic revisions. Depending on the likelihood of attaining infection clearance, it may sometimes be advisable to proceed directly to hip disarticulation without attempting salvage of the TFR. Other reported complications of TFR include hip joint instability, limb length discrepancy, device failure, component loosening, patellar maltracking and delayed wound healing. Further research is needed to better characterize the long-term functional outcomes and complications associated with this complex procedure. | Deepak Ramanathan Marcelo BP Siqueira Alison K Klika Carlos A Higuera Wael K Barsoum Michael J Joyce | 2015 | World Journal of Orthopedics2015，6，11： | 6 |
| 2 | Role of negative pressure wound therapy in total hip and knee arthroplasty显示文摘Negative-pressure wound therapy(NPWT) has been a successful modality of wound management which is in widespread use in several surgical fields. The main mechanisms of action thought to play a role in enhancing wound healing and preventing surgical site infection are macrodeformation and microdeformation of the wound bed, fluid removal, and stabilization of the wound environment. Due to the devastating consequences of infection in the setting of joint arthroplasty, there has been some interest in the use of NPWT following total hip arthroplasty and total knee arthroplasty. However, there is still a scarcity of data reporting on the use of NPWT within this field and most studies are limited by small sample sizes, high variability of clinical settings and end-points. There is little evidence to support the use of NPWT as an adjunctive treatment for surgical wound drainage, and for this reason surgical intervention should not be delayed when indicated. The prophylactic use of NPWT after arthroplasty in patients that are at high risk for postoperative wound drainage appears to have the strongest clinical evidence. Several clinical trialsincluding single-use NPWT devices for this purpose are currently in progress and this may soon be incorporated in clinical guidelines as a mean to prevent periprosthetic joint infections. | Marcelo BP Siqueira Deepak Ramanathan Alison K Klika Carlos A Higuera Wael K Barsoum | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 3 | Acute kidney injury and hepatorenal syndrome in cirrhosis显示文摘Acute kidney injury(AKI)in cirrhosis,including hepatorenal syndrome(HRS),is a common and serious complication in cirrhotic patients,leading to significant morbidity and mortality.AKI is separated into two categories,non-HRS AKI and HRS-AKI.The most recent definition and diagnostic criteria of AKI in cirrhosis and HRS have helped diagnose and prognosticate the disease.The pathophysiology behind non-HRS-AKI and HRS is more complicated than once theorized and involves more processes than just splanchnic vasodilation.The common biomarkers clinicians use to assess kidney injury have significant limitations in cirrhosis patients;novel biomarkers being studied have shown promise but require further studies in clinical settings and animal models.The overall management of non-HRS AKI and HRS-AKI requires a systematic approach.Although pharmacological treatments have shown mortality benefit,the ideal HRS treatment option is liver transplantation with or without simultaneous kidney transplantation.Further research is required to optimize pharmacologic and nonpharmacologic approaches to treatment.This article reviews the current guidelines and recommendations of AKI in cirrhosis. | Kapil Gupta Abhishek Bhurwal Cindy Law Scott Ventre Carlos D Minacapelli Savan Kabaria You Li Christopher Tait Carolyn Catalano Vinod K Rustgi | 2021 | World Journal of Gastroenterology2021，27，26： | 5 |
| 4 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 5 | The effect of flux diverters on AC loss of 110 kVA high tempera-ture superconducting demonstrator transformer显示文摘 | A Mosawi Carlo Beduz | 2001 | IEEE Trans on Appl Supercon2001，1，1： | 1 |
| 6 | A mutual network synchronization method for wireless Ad hoc and sensor networks 显示文摘 | Carlos R H and Thomas K | 2008 | IEEE Transactions on Mobile Computing2008，7，5： | 1 |
| 7 | Partitioned analysis of coupled mechanical systems显示文摘 | CARLOS A FELIPPA PARK K C | | 0，，： | 1 |
| 8 | Experimental study of reinforced concrete interior wide beam - column connections subjected to lateral loading显示文摘 | Carlos G Quintero - Febres James K Wight | 2001 | ACI Structural Journal2001，98，4： | 1 |
| 9 | Ligninolytic enzymes of the fungus Irpex lacteus ( Polyporus tulipiferae ): isolation and characterization of lignin peroxidase显示文摘 | Nathan Rothschild ?eněk Novotny Václav ?a?ek Carlos G Dosoretz | 2002 | Enzyme and Microbial Technology2002，，5： | 1 |
| 10 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 11 | Syntheses,calcium channel modulation effects,and nitric oxide releasing studies of O2-alkyl-1-(pyrrolidin)-1,4-dihydro-2,6-dimethyl-3-nitropyridine-5-carboxylates显示文摘 | CARLOS V DEAN V EDWARDS E K | 2003 | Drug Dev Res2003，60，3： | 1 |
| 12 | Emergency services in future intelligent transportationsystems based on vehicular communication networks显示文摘 | MARTINEZ F J TOH C K CARLOS C J | 2010 | IEEE Intelligent Transportation Systems Magazine2010，2，2： | 1 |
| 13 | Semi-conductor-assisted photodegradation of liglin, dye, and kraft effluent by Ag-doped ZnO 显示文摘 | Carlos A K Goerver F W Sandra G M | 2000 | Chenmosphere2000，40，4： | 1 |
| 14 | The Public Library Geographic Database:What Can It Do for Your Library? 显示文摘 | Christie M Koontz Dean K Joe Charles R McClure John Carlo Betroth | 2004 | Public Libraries2004，43，2： | 1 |
| 15 | Synthesis of Cyclopentitols by Ring - Closing Approaches显示文摘 | Vanya B K Carlos A M | 2009 | Chem Rev2009，109，： | 1 |
| 16 | Phylogenetic position of Symbiodinium (Dinophyceae) Isolates from Tridaenids (Bivalvia), Cardiids (Bivalvia), a sponge (Porifera), a Soft Coral (Anthozoa), and a Free-Living Strain 显示文摘 | Carlos A A Baillie B K Kawachi M | 1999 | J Phyeol1999，35，： | 1 |
| 17 | Differential alteration in intestinal epithelial cells expression of toll-like-receptors 3(TLR3) and TLR4 in inflammatory bowel disease显示文摘 | Carlo E Podolsky D K | 2000 | Infect Immunols2000，68，12： | 1 |
| 18 | Size control of poly (d, l-lactide-co-glycolide) and poly ( d, 1-1actide-co- glycolide )-magnetite nanoparticles synthesized by emulsion evaporation technique显示文摘 | CARLOS E A CHALLA K CRISTINA M S | 2007 | Colloids Surf A : Phy and Eng2007，299，3： | 1 |
| 19 | DNA from protozoan parasites babesia bovis, trypanosoma cruzi, and T, brucei is mitogenic for B lymphocyte and stimulates macrophage expression of Interleukine- 12, Tumor Necrosis Factor Alpha, and Nitric Oxide显示文摘 | LisL KM Kegerreis K Carlos E | 2001 | Infect Immun2001，69，4： | 1 |
| 20 | Quadrature sampling schemes with improved image rejection显示文摘 | PUN K P da FRANCA J E CARLOS A L | 2003 | IEEE Trans Circ and Syst2003，50，9： | 1 |
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